DDX39B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006405Biological processRNA export from nucleus
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0006406Biological processmRNA export from nucleus
GO_0008380Biological processRNA splicing
GO_0000245Biological processspliceosomal complex assembly
GO_0010501Biological processRNA secondary structure unwinding
GO_0000346Cellular componenttranscription export complex
GO_0005681Cellular componentspliceosomal complex
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005687Cellular componentU4 snRNP
GO_0005688Cellular componentU6 snRNP
GO_0005634Cellular componentnucleus
GO_0003724Molecular functionRNA helicase activity
GO_0042802Molecular functionidentical protein binding
GO_0003729Molecular functionmRNA binding
GO_0008186Molecular functionATP-dependent activity, acting on RNA
GO_0017070Molecular functionU6 snRNA binding
GO_0043008Molecular functionATP-dependent protein binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0030621Molecular functionU4 snRNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameDDX39B
Protein nameDExD-box helicase 39B
RNA helicase (EC 3.6.4.13)
DExD-box helicase 39B (Spliceosome RNA helicase DDX39B)
Spliceosome RNA helicase DDX39B
Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein)
Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (DEAD box protein UAP56)
SynonymsBAT1
UAP56
DescriptionFUNCTION: Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. .; FUNCTION: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. .; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. .

AccessionsENST00000456666.5 [Q13838-1]
ENST00000415036.5
A0A286SD59
ENST00000448658.5
ENST00000448296.5 [Q13838-1]
ENST00000493350.5
ENST00000430784.5 [Q13838-1]
ENST00000436995.5
ENST00000415027.5
ENST00000446341.5
ENST00000412106.5 [Q13838-1]
Q13838
ENST00000452163.5
ENST00000414088.5
ENST00000420337.5
ENST00000419913.5
ENST00000446328.5
ENST00000457900.1
A0A140T9B4
ENST00000433293.5
ENST00000441479.5
ENST00000442537.5
ENST00000416325.5
A0A140T9X3
ENST00000433291.5
ENST00000449100.5
ENST00000417558.5
ENST00000439691.5
ENST00000438449.5
ENST00000441901.1
ENST00000455645.5
ENST00000438578.5
ENST00000497007.5
ENST00000425047.1
ENST00000444267.5
ENST00000400295.5 [Q13838-1]
ENST00000428291.5
ENST00000444480.5
ENST00000415689.5 [Q13838-1]
Q5STU3
A0A140T9K2
ENST00000427489.5
ENST00000446272.5
ENST00000442717.5
ENST00000433987.5
H0Y400
A0A286SD52
F6R6M7
ENST00000452908.5
ENST00000431360.5 [Q13838-1]
ENST00000417491.5
ENST00000432466.5
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ENST00000417023.5
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ENST00000467694.6
ENST00000420958.5
ENST00000427214.5
ENST00000444726.5
ENST00000484344.5
A0A0G2JJZ9
ENST00000415515.5
F6UJC5
ENST00000445783.5
ENST00000453488.5
ENST00000414440.5 [Q13838-1]
ENST00000493860.5
ENST00000453799.1
F6QYI9
ENST00000450987.5
ENST00000411415.5
H0YCC6
ENST00000448800.5
ENST00000428450.5
ENST00000445602.5
ENST00000426189.5
A0A140T9A8
ENST00000455916.5
ENST00000441425.5 [Q13838-1]
ENST00000434740.5
ENST00000451465.1
ENST00000427652.5
A0A140T9X9
ENST00000439857.5
F6S4E6
ENST00000432549.5
ENST00000417995.5
F6WLT2
A0A0G2JJL7
A0A286SD67
ENST00000431908.5
ENST00000439927.5
ENST00000495997.5
ENST00000418897.5
ENST00000422243.5
F6S2B7
ENST00000400293.5
ENST00000433789.5
ENST00000449863.5
F6TRA5
ENST00000416183.5
A0A140TA18
ENST00000455806.5
ENST00000383508.6 [Q13838-1]
ENST00000445218.5 [Q13838-1]
ENST00000458640.5 [Q13838-1]
ENST00000416969.5
A0A140T996
ENST00000455400.5
ENST00000416863.5 [Q13838-1]
ENST00000423951.5
A0A140T9N3
ENST00000464411.5
ENST00000417136.5
ENST00000455324.5
ENST00000427425.5
ENST00000415390.5
F6U6E2
ENST00000438301.5
ENST00000400296.5 [Q13838-1]
ENST00000438883.5
ENST00000419338.5
A0A0A0MT12
ENST00000456476.5 [Q13838-1]
ENST00000432189.5
A0A140T9Q9
ENST00000456976.5
ENST00000412386.5
ENST00000412246.5
ENST00000436919.5
ENST00000449757.5
ENST00000446909.5
A0A286SD68
ENST00000419020.1
ENST00000443933.1
ENST00000413544.5
ENST00000396172.6 [Q13838-1]
ENST00000413678.5 [Q13838-1]
ENST00000449010.5
ENST00000414451.1
ENST00000435182.5
A0A286SD63
ENST00000428107.5
ENST00000430703.5
ENST00000429022.5
A0A0G2JHN7
ENST00000414881.5
ENST00000457121.5
ENST00000452792.5
ENST00000484566.5
ENST00000438433.5
ENST00000482080.5
ENST00000453138.5 [Q13838-1]
F6SXL5
ENST00000437943.5
A0A140T973
ENST00000456662.5
ENST00000448000.5
ENST00000451051.5
A0A286SD65
ENST00000376177.6
ENST00000418760.5
ENST00000426766.5
ENST00000452414.5
A0A140T9K1
ENST00000427927.5
A0A140T9L4
ENST00000412330.5 [Q13838-1]
A0A286SD64