DDX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0090304Biological processnucleic acid metabolic process
GO_0045087Biological processinnate immune response
GO_0006302Biological processdouble-strand break repair
GO_0002735Biological processpositive regulation of myeloid dendritic cell cytokine production
GO_0043330Biological processresponse to exogenous dsRNA
GO_1903608Biological processprotein localization to cytoplasmic stress granule
GO_0051607Biological processdefense response to virus
GO_0006446Biological processregulation of translational initiation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0006388Biological processtRNA splicing, via endonucleolytic cleavage and ligation
GO_0000245Biological processspliceosomal complex assembly
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0072669Cellular componenttRNA-splicing ligase complex
GO_0010494Cellular componentcytoplasmic stress granule
GO_0071920Cellular componentcleavage body
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0008143Molecular functionpoly(A) binding
GO_0004527Molecular functionexonuclease activity
GO_0003724Molecular functionRNA helicase activity
GO_0003682Molecular functionchromatin binding
GO_0033677Molecular functionDNA/RNA helicase activity
GO_0003712Molecular functiontranscription coregulator activity
GO_0004518Molecular functionnuclease activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameDDX1
Protein nameATP-dependent RNA helicase DDX1
ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1)
RNA helicase (EC 3.6.4.13)
ATP-dependent RNA helicase (EC 3.6.4.13)
ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB)
SynonymshCG_15914
DescriptionFUNCTION: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation . Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). .; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. .; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. .

FUNCTION: RNA helicase. .

FUNCTION: RNA helicase. .

AccessionsENST00000381341.7 [Q92499-1]
A0A7I2YQ77
A0A087X2G1
A3RJH1
ENST00000676916.1
ENST00000434671
ENST00000678137.1
ENST00000677355.1
ENST00000676635.1
ENST00000677437.1
A0A7I2V430
Q92499
A0A7I2V4F0
ENST00000621973.2
A0A7I2V4Q0
A0A7I2V5X8
ENST00000233084.8 [Q92499-1]
A0A7I2YQD0
A0A7I2V421
A0A7I2V2M5
A0A7I2V4J3
F1T0B3
C9JLP0
ENST00000678786.1
ENST00000617198.5
ENST00000676937.1
ENST00000434671.2 [Q92499-1]
ENST00000677302.1 [Q92499-1]
ENST00000677552.1
ENST00000678391.1
ENST00000678594.1
A0A087WZ71