Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 14 studies | 23% ± 10% | |
endothelial cell | 12 studies | 28% ± 10% | |
pericyte | 11 studies | 20% ± 5% | |
smooth muscle cell | 10 studies | 19% ± 4% | |
ciliated cell | 9 studies | 29% ± 10% | |
connective tissue cell | 8 studies | 26% ± 10% | |
endothelial cell of lymphatic vessel | 8 studies | 20% ± 6% | |
basal cell | 7 studies | 29% ± 11% | |
oligodendrocyte precursor cell | 7 studies | 30% ± 8% | |
neuron | 6 studies | 29% ± 15% | |
epithelial cell | 6 studies | 41% ± 16% | |
astrocyte | 6 studies | 27% ± 8% | |
glutamatergic neuron | 6 studies | 46% ± 24% | |
oligodendrocyte | 6 studies | 27% ± 5% | |
myofibroblast cell | 5 studies | 20% ± 3% | |
GABAergic neuron | 5 studies | 40% ± 19% | |
interneuron | 5 studies | 37% ± 19% | |
pancreatic A cell | 4 studies | 35% ± 14% | |
retinal ganglion cell | 4 studies | 52% ± 29% | |
retinal cone cell | 4 studies | 40% ± 19% | |
lymphocyte | 4 studies | 18% ± 4% | |
erythroblast | 4 studies | 34% ± 16% | |
macrophage | 4 studies | 19% ± 2% | |
endothelial cell of vascular tree | 4 studies | 17% ± 1% | |
goblet cell | 4 studies | 28% ± 6% | |
ionocyte | 3 studies | 28% ± 7% | |
type B pancreatic cell | 3 studies | 40% ± 16% | |
epithelial cell of proximal tubule | 3 studies | 17% ± 2% | |
kidney loop of Henle epithelial cell | 3 studies | 25% ± 4% | |
progenitor cell | 3 studies | 18% ± 2% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 26% ± 6% | |
abnormal cell | 3 studies | 28% ± 8% | |
neural crest cell | 3 studies | 24% ± 5% | |
microglial cell | 3 studies | 21% ± 1% | |
club cell | 3 studies | 22% ± 6% | |
amacrine cell | 3 studies | 37% ± 12% | |
retina horizontal cell | 3 studies | 26% ± 14% | |
retinal rod cell | 3 studies | 29% ± 12% | |
rod bipolar cell | 3 studies | 21% ± 3% | |
type I pneumocyte | 3 studies | 22% ± 6% | |
pancreatic ductal cell | 3 studies | 41% ± 17% | |
enteroendocrine cell | 3 studies | 27% ± 13% | |
erythrocyte | 3 studies | 31% ± 14% | |
transit amplifying cell | 3 studies | 26% ± 9% | |
mesothelial cell | 3 studies | 28% ± 16% | |
mast cell | 3 studies | 18% ± 3% | |
adipocyte | 3 studies | 21% ± 7% | |
hepatocyte | 3 studies | 30% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 5764.35 | 1445 / 1445 | 100% | 35.02 | 183 / 183 |
intestine | 100% | 5769.11 | 966 / 966 | 100% | 39.82 | 527 / 527 |
ovary | 100% | 4688.81 | 180 / 180 | 100% | 23.64 | 430 / 430 |
stomach | 100% | 4580.49 | 359 / 359 | 100% | 35.22 | 286 / 286 |
breast | 100% | 5614.23 | 459 / 459 | 100% | 46.46 | 1117 / 1118 |
bladder | 100% | 5606.52 | 21 / 21 | 100% | 38.97 | 503 / 504 |
prostate | 100% | 4034.99 | 245 / 245 | 100% | 34.54 | 501 / 502 |
uterus | 100% | 4890.02 | 170 / 170 | 100% | 43.03 | 458 / 459 |
pancreas | 100% | 3539.00 | 327 / 328 | 100% | 29.97 | 178 / 178 |
kidney | 100% | 4416.71 | 89 / 89 | 100% | 31.56 | 897 / 901 |
thymus | 100% | 5238.66 | 653 / 653 | 100% | 40.82 | 602 / 605 |
lung | 99% | 4278.49 | 575 / 578 | 100% | 39.04 | 1154 / 1155 |
skin | 100% | 6717.07 | 1809 / 1809 | 99% | 42.79 | 469 / 472 |
brain | 99% | 5104.73 | 2625 / 2642 | 100% | 45.42 | 705 / 705 |
adrenal gland | 100% | 5960.80 | 258 / 258 | 99% | 36.41 | 227 / 230 |
liver | 99% | 2692.47 | 223 / 226 | 100% | 23.96 | 406 / 406 |
blood vessel | 100% | 6544.54 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 30.15 | 29 / 29 |
muscle | 100% | 9888.42 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3825.24 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 36.63 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 10.62 | 1 / 1 |
adipose | 100% | 5582.28 | 1203 / 1204 | 0% | 0 | 0 / 0 |
heart | 97% | 6186.87 | 832 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 94% | 27.51 | 75 / 80 |
peripheral blood | 43% | 1913.12 | 397 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0032508 | Biological process | DNA duplex unwinding |
GO_0090304 | Biological process | nucleic acid metabolic process |
GO_0045087 | Biological process | innate immune response |
GO_0006302 | Biological process | double-strand break repair |
GO_0002735 | Biological process | positive regulation of myeloid dendritic cell cytokine production |
GO_0043330 | Biological process | response to exogenous dsRNA |
GO_1903608 | Biological process | protein localization to cytoplasmic stress granule |
GO_0051607 | Biological process | defense response to virus |
GO_0006446 | Biological process | regulation of translational initiation |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0006388 | Biological process | tRNA splicing, via endonucleolytic cleavage and ligation |
GO_0000245 | Biological process | spliceosomal complex assembly |
GO_0016020 | Cellular component | membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_1990904 | Cellular component | ribonucleoprotein complex |
GO_0072669 | Cellular component | tRNA-splicing ligase complex |
GO_0010494 | Cellular component | cytoplasmic stress granule |
GO_0071920 | Cellular component | cleavage body |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0008143 | Molecular function | poly(A) binding |
GO_0004527 | Molecular function | exonuclease activity |
GO_0003724 | Molecular function | RNA helicase activity |
GO_0003682 | Molecular function | chromatin binding |
GO_0033677 | Molecular function | DNA/RNA helicase activity |
GO_0003712 | Molecular function | transcription coregulator activity |
GO_0004518 | Molecular function | nuclease activity |
GO_0005524 | Molecular function | ATP binding |
GO_0003723 | Molecular function | RNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
GO_0003725 | Molecular function | double-stranded RNA binding |
Gene name | DDX1 |
Protein name | ATP-dependent RNA helicase DDX1 ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) RNA helicase (EC 3.6.4.13) ATP-dependent RNA helicase (EC 3.6.4.13) ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) |
Synonyms | hCG_15914 |
Description | FUNCTION: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation . Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). .; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. .; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. . FUNCTION: RNA helicase. . FUNCTION: RNA helicase. . |
Accessions | ENST00000381341.7 [Q92499-1] A0A7I2YQ77 A0A087X2G1 A3RJH1 ENST00000676916.1 ENST00000434671 ENST00000678137.1 ENST00000677355.1 ENST00000676635.1 ENST00000677437.1 A0A7I2V430 Q92499 A0A7I2V4F0 ENST00000621973.2 A0A7I2V4Q0 A0A7I2V5X8 ENST00000233084.8 [Q92499-1] A0A7I2YQD0 A0A7I2V421 A0A7I2V2M5 A0A7I2V4J3 F1T0B3 C9JLP0 ENST00000678786.1 ENST00000617198.5 ENST00000676937.1 ENST00000434671.2 [Q92499-1] ENST00000677302.1 [Q92499-1] ENST00000677552.1 ENST00000678391.1 ENST00000678594.1 A0A087WZ71 |