CTSA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	33 studies	35% ± 12%	Explore
classical monocyte	23 studies	37% ± 15%	Explore
monocyte	18 studies	29% ± 9%	Explore
non-classical monocyte	18 studies	30% ± 13%	Explore
endothelial cell	18 studies	24% ± 8%	Explore
regulatory T cell	14 studies	28% ± 7%	Explore
myeloid cell	12 studies	32% ± 12%	Explore
fibroblast	12 studies	30% ± 11%	Explore
platelet	11 studies	63% ± 20%	Explore
mucosal invariant T cell	10 studies	28% ± 7%	Explore
conventional dendritic cell	9 studies	34% ± 16%	Explore
epithelial cell	9 studies	40% ± 12%	Explore
natural killer cell	8 studies	24% ± 10%	Explore
CD8-positive, alpha-beta T cell	8 studies	20% ± 3%	Explore
gamma-delta T cell	8 studies	18% ± 2%	Explore
alveolar macrophage	7 studies	29% ± 6%	Explore
CD4-positive, alpha-beta T cell	7 studies	21% ± 3%	Explore
enterocyte	7 studies	33% ± 10%	Explore
pericyte	7 studies	24% ± 7%	Explore
T cell	7 studies	19% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	22% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	21% ± 3%	Explore
epithelial cell of proximal tubule	6 studies	28% ± 5%	Explore
capillary endothelial cell	6 studies	18% ± 2%	Explore
endothelial cell of lymphatic vessel	6 studies	25% ± 6%	Explore
type I pneumocyte	6 studies	23% ± 9%	Explore
dendritic cell	6 studies	29% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	22% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	17% ± 2%	Explore
connective tissue cell	5 studies	25% ± 10%	Explore
memory B cell	5 studies	18% ± 1%	Explore
mature NK T cell	5 studies	21% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	21% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	21% ± 7%	Explore
secretory cell	4 studies	24% ± 7%	Explore
hematopoietic precursor cell	4 studies	22% ± 6%	Explore
smooth muscle cell	4 studies	25% ± 5%	Explore
megakaryocyte	4 studies	46% ± 16%	Explore
basal cell	4 studies	25% ± 9%	Explore
astrocyte	4 studies	20% ± 6%	Explore
vein endothelial cell	4 studies	17% ± 2%	Explore
mononuclear phagocyte	4 studies	25% ± 6%	Explore
ciliated cell	4 studies	25% ± 3%	Explore
T follicular helper cell	4 studies	22% ± 7%	Explore
endothelial cell of vascular tree	4 studies	23% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	23% ± 5%	Explore
plasma cell	3 studies	29% ± 10%	Explore
squamous epithelial cell	3 studies	37% ± 21%	Explore
pancreatic A cell	3 studies	29% ± 11%	Explore
exhausted T cell	3 studies	24% ± 5%	Explore
glomerular endothelial cell	3 studies	18% ± 2%	Explore
leukocyte	3 studies	22% ± 5%	Explore
glutamatergic neuron	3 studies	34% ± 13%	Explore
retinal ganglion cell	3 studies	47% ± 19%	Explore
common myeloid progenitor	3 studies	29% ± 8%	Explore
tissue-resident macrophage	3 studies	34% ± 14%	Explore
progenitor cell	3 studies	19% ± 2%	Explore
Mueller cell	3 studies	19% ± 4%	Explore
abnormal cell	3 studies	40% ± 17%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	26% ± 5%	Explore
intermediate monocyte	3 studies	48% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	17% ± 2%	Explore
inflammatory macrophage	3 studies	29% ± 15%	Explore
neutrophil	3 studies	22% ± 4%	Explore
endothelial cell of artery	3 studies	18% ± 2%	Explore
innate lymphoid cell	3 studies	19% ± 2%	Explore
plasmacytoid dendritic cell	3 studies	22% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	23% ± 7%	Explore
lung	9 studies	23% ± 8%	Explore
intestine	8 studies	18% ± 3%	Explore
kidney	6 studies	23% ± 5%	Explore
brain	4 studies	29% ± 6%	Explore
placenta	3 studies	21% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	5203.99	180 / 180	100%	56.30	430 / 430
skin	100%	7818.73	1809 / 1809	100%	112.42	472 / 472
stomach	100%	3678.43	359 / 359	100%	99.31	286 / 286
esophagus	100%	3902.24	1444 / 1445	100%	60.00	183 / 183
intestine	100%	7799.32	966 / 966	100%	84.20	526 / 527
lung	100%	7034.59	578 / 578	100%	63.60	1152 / 1155
uterus	100%	3750.74	170 / 170	100%	47.54	457 / 459
kidney	100%	11523.12	89 / 89	100%	70.35	897 / 901
bladder	100%	4739.48	21 / 21	99%	62.31	501 / 504
thymus	100%	3894.66	652 / 653	100%	39.74	602 / 605
adrenal gland	100%	25940.87	258 / 258	99%	111.66	228 / 230
breast	100%	4738.42	459 / 459	99%	40.41	1105 / 1118
liver	99%	3603.49	223 / 226	100%	69.64	405 / 406
prostate	99%	3177.62	243 / 245	98%	24.72	491 / 502
brain	95%	2466.79	2514 / 2642	100%	35.91	703 / 705
pancreas	95%	2245.76	313 / 328	99%	59.03	176 / 178
adipose	100%	6019.35	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	77.80	80 / 80
lymph node	0%	0	0 / 0	100%	49.81	29 / 29
spleen	100%	7940.68	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	38.09	45 / 45
ureter	0%	0	0 / 0	100%	17.94	1 / 1
blood vessel	100%	5690.52	1332 / 1335	0%	0	0 / 0
peripheral blood	99%	7792.96	923 / 929	0%	0	0 / 0
heart	98%	4543.65	844 / 861	0%	0	0 / 0
muscle	98%	2275.94	784 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006886	Biological process	intracellular protein transport
GO_1904714	Biological process	regulation of chaperone-mediated autophagy
GO_0006508	Biological process	proteolysis
GO_0031647	Biological process	regulation of protein stability
GO_1904715	Biological process	negative regulation of chaperone-mediated autophagy
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0035578	Cellular component	azurophil granule lumen
GO_0043202	Cellular component	lysosomal lumen
GO_0005764	Cellular component	lysosome
GO_0098575	Cellular component	lumenal side of lysosomal membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005576	Cellular component	extracellular region
GO_0016020	Cellular component	membrane
GO_0008047	Molecular function	enzyme activator activity
GO_0004180	Molecular function	carboxypeptidase activity
GO_0004185	Molecular function	serine-type carboxypeptidase activity

IV. Literature review

[source]

Gene name	CTSA
Protein name	Carboxypeptidase (EC 3.4.16.-) Lysosomal protective protein (EC 3.4.16.5) (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain] Alternative protein CTSA Lysosomal protective protein Cathepsin A
Synonyms	PPGB
Description	FUNCTION: Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins. .
Accessions	ENST00000354880.9 ENST00000676657.1 ENST00000372484.8 ENST00000678331.1 A0A7I2V504 ENST00000678217.1 ENST00000676967.1 ENST00000677525.1 A0A7I2V3B2 ENST00000676597.1 ENST00000646241.3 [P10619-1] A0A7I2YQT8 ENST00000678078.1 ENST00000676526.1 A0A7I2V4R8 ENST00000606788.5 ENST00000191018.9 [P10619-1] Q5JZH0 ENST00000607482.6 [P10619-1] L8E8P5 A0A7I2V4K5 ENST00000678025.1 A0A7I2V4D1 X6R8A1 ENST00000606394.6 X6R5C5 A0A7I2V2E2 U3KQF1 U3KQ41 U3KQU6 ENST00000678443.1 ENST00000607482 ENST00000372459.7 [P10619-1] ENST00000419493.3 A0A7I2V4Q9 ENST00000678939.1 P10619 ENST00000677394.1 ENST00000354880.9 [P10619-2] A0A7I2V3M2

CTSA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review