CREBRF | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	25 studies	26% ± 9%	Explore
B cell	21 studies	24% ± 12%	Explore
fibroblast	16 studies	22% ± 7%	Explore
macrophage	15 studies	25% ± 10%	Explore
natural killer cell	14 studies	24% ± 10%	Explore
pericyte	13 studies	23% ± 7%	Explore
naive B cell	12 studies	22% ± 6%	Explore
regulatory T cell	12 studies	22% ± 8%	Explore
CD8-positive, alpha-beta T cell	11 studies	21% ± 11%	Explore
memory B cell	11 studies	21% ± 5%	Explore
CD4-positive, alpha-beta T cell	10 studies	25% ± 14%	Explore
classical monocyte	9 studies	25% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	21% ± 7%	Explore
oligodendrocyte	9 studies	28% ± 10%	Explore
smooth muscle cell	8 studies	23% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	27% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	25% ± 11%	Explore
T cell	7 studies	21% ± 5%	Explore
endothelial cell of lymphatic vessel	7 studies	26% ± 3%	Explore
glutamatergic neuron	7 studies	43% ± 24%	Explore
microglial cell	7 studies	28% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	25% ± 10%	Explore
non-classical monocyte	6 studies	35% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	26% ± 10%	Explore
neutrophil	6 studies	24% ± 4%	Explore
monocyte	6 studies	22% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	23% ± 4%	Explore
GABAergic neuron	6 studies	42% ± 19%	Explore
type II pneumocyte	5 studies	22% ± 4%	Explore
mononuclear phagocyte	5 studies	18% ± 2%	Explore
mature NK T cell	5 studies	23% ± 6%	Explore
capillary endothelial cell	5 studies	23% ± 2%	Explore
neuron	5 studies	26% ± 11%	Explore
epithelial cell	5 studies	41% ± 14%	Explore
basal cell	5 studies	24% ± 11%	Explore
lymphocyte	5 studies	28% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	19% ± 3%	Explore
gamma-delta T cell	5 studies	24% ± 3%	Explore
astrocyte	5 studies	33% ± 10%	Explore
leukocyte	4 studies	25% ± 3%	Explore
conventional dendritic cell	4 studies	26% ± 11%	Explore
myeloid cell	4 studies	28% ± 8%	Explore
mast cell	4 studies	27% ± 12%	Explore
ciliated cell	4 studies	28% ± 15%	Explore
dendritic cell	4 studies	37% ± 15%	Explore
adipocyte	4 studies	23% ± 6%	Explore
oligodendrocyte precursor cell	4 studies	30% ± 9%	Explore
interneuron	4 studies	46% ± 24%	Explore
glomerular endothelial cell	3 studies	23% ± 2%	Explore
kidney loop of Henle epithelial cell	3 studies	18% ± 2%	Explore
retina horizontal cell	3 studies	24% ± 8%	Explore
mucosal invariant T cell	3 studies	16% ± 1%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	36% ± 15%	Explore
alveolar macrophage	3 studies	23% ± 7%	Explore
T follicular helper cell	3 studies	21% ± 4%	Explore
endothelial cell of vascular tree	3 studies	29% ± 10%	Explore
melanocyte	3 studies	32% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	16% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	10 studies	34% ± 18%	Explore
peripheral blood	7 studies	31% ± 12%	Explore
eye	5 studies	24% ± 10%	Explore
lung	4 studies	24% ± 7%	Explore
intestine	3 studies	17% ± 1%	Explore
liver	3 studies	21% ± 5%	Explore
adipose	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	4089.31	653 / 653	100%	18.59	603 / 605
kidney	100%	2211.35	89 / 89	99%	14.58	896 / 901
brain	99%	1923.92	2625 / 2642	100%	10.22	704 / 705
prostate	100%	3169.70	244 / 245	100%	9.84	500 / 502
esophagus	99%	2736.64	1429 / 1445	100%	8.27	183 / 183
breast	100%	4127.07	459 / 459	98%	9.70	1100 / 1118
ovary	100%	3969.48	180 / 180	98%	5.79	421 / 430
lung	100%	4104.49	578 / 578	98%	6.95	1129 / 1155
adrenal gland	98%	2267.55	254 / 258	99%	10.21	227 / 230
pancreas	98%	1322.77	321 / 328	97%	8.48	172 / 178
stomach	100%	2196.60	359 / 359	94%	6.30	270 / 286
uterus	100%	4150.84	170 / 170	91%	4.62	418 / 459
bladder	100%	3827.29	21 / 21	90%	4.56	454 / 504
intestine	100%	3335.43	966 / 966	90%	5.12	473 / 527
skin	98%	2959.29	1778 / 1809	91%	8.26	429 / 472
liver	98%	1525.88	221 / 226	90%	4.50	364 / 406
blood vessel	100%	4469.79	1335 / 1335	0%	0	0 / 0
spleen	100%	4290.90	241 / 241	0%	0	0 / 0
adipose	100%	4093.81	1203 / 1204	0%	0	0 / 0
peripheral blood	99%	4616.06	917 / 929	0%	0	0 / 0
muscle	97%	1852.94	781 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	6.73	28 / 29
heart	95%	1612.22	821 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	5.37	41 / 45
eye	0%	0	0 / 0	81%	5.63	65 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006986	Biological process	response to unfolded protein
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977	Molecular function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0005515	Molecular function	protein binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]

Gene name	CREBRF
Protein name	CREB3 regulatory factor CREB3 regulatory factor (Luman recruitment factor) (LRF)
Synonyms	C5orf41
Description	FUNCTION: Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci. .
Accessions	ENST00000522692.5 [Q8IUR6-2] E5RI19 ENST00000520420.5 [Q8IUR6-2] ENST00000296953.6 [Q8IUR6-1] ENST00000523161.1 Q8IUR6

CREBRF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review