Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 25 studies | 44% ± 16% | |
| astrocyte | 19 studies | 44% ± 20% | |
| oligodendrocyte | 15 studies | 44% ± 17% | |
| microglial cell | 15 studies | 53% ± 15% | |
| macrophage | 13 studies | 42% ± 19% | |
| oligodendrocyte precursor cell | 13 studies | 49% ± 18% | |
| glutamatergic neuron | 12 studies | 52% ± 25% | |
| fibroblast | 11 studies | 48% ± 13% | |
| GABAergic neuron | 10 studies | 53% ± 19% | |
| smooth muscle cell | 10 studies | 37% ± 11% | |
| pericyte | 9 studies | 42% ± 14% | |
| adipocyte | 9 studies | 49% ± 13% | |
| mast cell | 8 studies | 34% ± 8% | |
| endothelial cell of lymphatic vessel | 8 studies | 49% ± 18% | |
| epithelial cell | 7 studies | 37% ± 20% | |
| B cell | 7 studies | 37% ± 11% | |
| interneuron | 6 studies | 62% ± 21% | |
| ciliated cell | 6 studies | 33% ± 15% | |
| monocyte | 6 studies | 48% ± 21% | |
| T cell | 6 studies | 39% ± 10% | |
| myeloid cell | 6 studies | 35% ± 11% | |
| neuron | 5 studies | 56% ± 19% | |
| cardiac muscle cell | 5 studies | 36% ± 6% | |
| dendritic cell | 5 studies | 42% ± 8% | |
| mesothelial cell | 5 studies | 43% ± 11% | |
| basal cell | 5 studies | 52% ± 22% | |
| type I pneumocyte | 5 studies | 43% ± 6% | |
| type II pneumocyte | 5 studies | 43% ± 8% | |
| granule cell | 4 studies | 44% ± 6% | |
| plasma cell | 4 studies | 42% ± 14% | |
| CD4-positive, alpha-beta T cell | 4 studies | 29% ± 8% | |
| vein endothelial cell | 4 studies | 39% ± 25% | |
| Mueller cell | 4 studies | 44% ± 16% | |
| amacrine cell | 4 studies | 45% ± 14% | |
| retina horizontal cell | 4 studies | 43% ± 18% | |
| retinal cone cell | 4 studies | 39% ± 13% | |
| retinal rod cell | 4 studies | 47% ± 14% | |
| club cell | 4 studies | 46% ± 11% | |
| natural killer cell | 4 studies | 37% ± 6% | |
| leukocyte | 4 studies | 57% ± 4% | |
| differentiation-committed oligodendrocyte precursor | 3 studies | 43% ± 5% | |
| GABAergic interneuron | 3 studies | 43% ± 5% | |
| progenitor cell | 3 studies | 48% ± 11% | |
| CD8-positive, alpha-beta T cell | 3 studies | 30% ± 6% | |
| GABAergic amacrine cell | 3 studies | 48% ± 14% | |
| glycinergic amacrine cell | 3 studies | 44% ± 16% | |
| retinal ganglion cell | 3 studies | 39% ± 13% | |
| endothelial cell of vascular tree | 3 studies | 51% ± 20% | |
| hepatocyte | 3 studies | 65% ± 19% | |
| retinal pigment epithelial cell | 3 studies | 49% ± 26% | |
| ependymal cell | 3 studies | 49% ± 17% | |
| alveolar macrophage | 3 studies | 52% ± 7% | |
| capillary endothelial cell | 3 studies | 38% ± 7% | |
| respiratory goblet cell | 3 studies | 45% ± 16% | |
| lymphocyte | 3 studies | 45% ± 17% | |
| transit amplifying cell | 3 studies | 46% ± 34% | |
| mural cell | 3 studies | 51% ± 9% | |
| mucus secreting cell | 3 studies | 44% ± 14% | |
| regulatory T cell | 3 studies | 34% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 885.05 | 459 / 459 | 100% | 17.87 | 1118 / 1118 |
| thymus | 100% | 876.91 | 653 / 653 | 100% | 20.24 | 605 / 605 |
| lung | 100% | 736.03 | 578 / 578 | 100% | 18.77 | 1153 / 1155 |
| prostate | 100% | 686.49 | 245 / 245 | 100% | 10.16 | 501 / 502 |
| uterus | 100% | 900.64 | 170 / 170 | 100% | 17.91 | 458 / 459 |
| ovary | 100% | 933.45 | 180 / 180 | 100% | 14.45 | 429 / 430 |
| intestine | 100% | 703.64 | 966 / 966 | 100% | 13.62 | 525 / 527 |
| bladder | 100% | 742.52 | 21 / 21 | 100% | 21.32 | 502 / 504 |
| esophagus | 100% | 625.58 | 1445 / 1445 | 99% | 16.05 | 182 / 183 |
| skin | 100% | 885.22 | 1809 / 1809 | 99% | 20.46 | 469 / 472 |
| brain | 99% | 368.00 | 2625 / 2642 | 100% | 14.57 | 705 / 705 |
| stomach | 100% | 545.65 | 359 / 359 | 99% | 12.71 | 283 / 286 |
| pancreas | 100% | 456.30 | 328 / 328 | 99% | 11.32 | 176 / 178 |
| kidney | 100% | 537.82 | 89 / 89 | 97% | 12.39 | 878 / 901 |
| adrenal gland | 100% | 504.58 | 258 / 258 | 97% | 8.90 | 222 / 230 |
| liver | 100% | 306.47 | 226 / 226 | 95% | 8.93 | 385 / 406 |
| adipose | 100% | 809.06 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 736.61 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 14.07 | 29 / 29 |
| spleen | 100% | 765.82 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 17.75 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.98 | 1 / 1 |
| muscle | 100% | 725.31 | 802 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 394.98 | 847 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 98% | 12.58 | 78 / 80 |
| peripheral blood | 88% | 508.99 | 820 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1990145 | Biological process | maintenance of translational fidelity |
| GO_0035600 | Biological process | tRNA methylthiolation |
| GO_0008150 | Biological process | biological_process |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005791 | Cellular component | rough endoplasmic reticulum |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005515 | Molecular function | protein binding |
| GO_0051539 | Molecular function | 4 iron, 4 sulfur cluster binding |
| GO_0035598 | Molecular function | N6-threonylcarbomyladenosine methylthiotransferase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0061712 | Molecular function | tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase |
| Gene name | CDKAL1 |
| Protein name | Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5 regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase) |
| Synonyms | |
| Description | FUNCTION: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. . |
| Accessions | ENST00000378610.1 [Q5VV42-1] Q5VV42 ENST00000274695.8 [Q5VV42-1] ENST00000613575.4 [Q5VV42-3] |