CDH1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	17 studies	39% ± 16%	Explore
epithelial cell	17 studies	36% ± 20%	Explore
basal cell	13 studies	30% ± 13%	Explore
type I pneumocyte	12 studies	42% ± 12%	Explore
type II pneumocyte	9 studies	28% ± 6%	Explore
club cell	9 studies	33% ± 11%	Explore
secretory cell	8 studies	30% ± 6%	Explore
goblet cell	8 studies	40% ± 17%	Explore
respiratory goblet cell	7 studies	28% ± 11%	Explore
enterocyte	6 studies	27% ± 7%	Explore
transit amplifying cell	5 studies	27% ± 13%	Explore
renal alpha-intercalated cell	5 studies	29% ± 9%	Explore
brush cell	5 studies	26% ± 8%	Explore
ionocyte	4 studies	35% ± 12%	Explore
pancreatic A cell	4 studies	42% ± 22%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	41% ± 9%	Explore
hepatocyte	4 studies	35% ± 17%	Explore
luminal cell of prostate epithelium	4 studies	39% ± 7%	Explore
oligodendrocyte	4 studies	30% ± 11%	Explore
renal principal cell	4 studies	38% ± 15%	Explore
placental villous trophoblast	3 studies	22% ± 3%	Explore
squamous epithelial cell	3 studies	44% ± 23%	Explore
progenitor cell	3 studies	26% ± 4%	Explore
acinar cell	3 studies	57% ± 26%	Explore
pancreatic ductal cell	3 studies	71% ± 18%	Explore
keratinocyte	3 studies	25% ± 6%	Explore
mucus secreting cell	3 studies	27% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	6 studies	26% ± 11%	Explore
pancreas	4 studies	39% ± 23%	Explore
liver	3 studies	21% ± 5%	Explore
intestine	3 studies	19% ± 5%	Explore
prostate	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	11575.07	328 / 328	98%	233.48	174 / 178
thymus	100%	16245.38	651 / 653	97%	363.68	587 / 605
prostate	89%	8127.21	217 / 245	99%	325.27	498 / 502
lung	79%	4422.89	455 / 578	97%	227.84	1123 / 1155
stomach	74%	8711.84	265 / 359	95%	265.71	271 / 286
liver	95%	4991.02	215 / 226	66%	93.12	266 / 406
breast	58%	5017.46	266 / 459	88%	293.77	986 / 1118
kidney	94%	4874.87	84 / 89	49%	53.86	442 / 901
intestine	46%	8925.72	440 / 966	98%	294.89	515 / 527
bladder	43%	3989.71	9 / 21	94%	264.18	476 / 504
esophagus	39%	7946.24	557 / 1445	97%	244.40	178 / 183
skin	72%	11168.13	1305 / 1809	55%	122.48	261 / 472
ureter	0%	0	0 / 0	100%	297.74	1 / 1
tonsil	0%	0	0 / 0	98%	180.53	44 / 45
uterus	6%	347.70	10 / 170	85%	200.37	389 / 459
ovary	2%	31.41	3 / 180	89%	103.72	381 / 430
eye	0%	0	0 / 0	84%	207.67	67 / 80
spleen	29%	759.97	71 / 241	0%	0	0 / 0
peripheral blood	3%	88.45	28 / 929	0%	0	0 / 0
adipose	1%	38.45	14 / 1204	0%	0	0 / 0
adrenal gland	0%	16.92	1 / 258	0%	0	0 / 230
muscle	0%	5.38	2 / 803	0%	0	0 / 0
blood vessel	0%	9.29	3 / 1335	0%	0	0 / 0
brain	0%	1.56	2 / 2642	0%	0.07	1 / 705
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007043	Biological process	cell-cell junction assembly
GO_0010468	Biological process	regulation of gene expression
GO_0034332	Biological process	adherens junction organization
GO_0072659	Biological process	protein localization to plasma membrane
GO_0140459	Biological process	response to Gram-positive bacterium
GO_0031175	Biological process	neuron projection development
GO_0042307	Biological process	positive regulation of protein import into nucleus
GO_0007275	Biological process	multicellular organism development
GO_0044331	Biological process	cell-cell adhesion mediated by cadherin
GO_0099576	Biological process	regulation of protein catabolic process at postsynapse, modulating synaptic transmission
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0007156	Biological process	homophilic cell adhesion via plasma membrane adhesion molecules
GO_0016339	Biological process	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0030517	Biological process	negative regulation of axon extension
GO_0030336	Biological process	negative regulation of cell migration
GO_0000902	Biological process	cell morphogenesis
GO_0007416	Biological process	synapse assembly
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0009636	Biological process	response to toxic substance
GO_0021983	Biological process	pituitary gland development
GO_0098609	Biological process	cell-cell adhesion
GO_0016477	Biological process	cell migration
GO_0071681	Biological process	cellular response to indole-3-methanol
GO_0071285	Biological process	cellular response to lithium ion
GO_0022408	Biological process	negative regulation of cell-cell adhesion
GO_0098978	Cellular component	glutamatergic synapse
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0098794	Cellular component	postsynapse
GO_0030864	Cellular component	cortical actin cytoskeleton
GO_0016342	Cellular component	catenin complex
GO_0016600	Cellular component	flotillin complex
GO_0005802	Cellular component	trans-Golgi network
GO_0043296	Cellular component	apical junction complex
GO_0015629	Cellular component	actin cytoskeleton
GO_0005912	Cellular component	adherens junction
GO_0016328	Cellular component	lateral plasma membrane
GO_0030054	Cellular component	cell junction
GO_0005768	Cellular component	endosome
GO_0030027	Cellular component	lamellipodium
GO_0032794	Molecular function	GTPase activating protein binding
GO_0045296	Molecular function	cadherin binding
GO_0042802	Molecular function	identical protein binding
GO_0008013	Molecular function	beta-catenin binding
GO_1990782	Molecular function	protein tyrosine kinase binding
GO_0045295	Molecular function	gamma-catenin binding
GO_0050839	Molecular function	cell adhesion molecule binding
GO_0030506	Molecular function	ankyrin binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CDH1
Protein name	E-cadherin 1 Truncated E-cadherin E-cadherin Cadherin-1 (Epithelial cadherin) CDH1 protein Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] Cadherin 1
Synonyms	CDHE UVO
Description	FUNCTION: Cadherins are calcium-dependent cell adhesion proteins . They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells . Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. .; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. .; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. . FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. .; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. . FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. .; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. . FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. .; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. .
Accessions	H3BVI7 A5D8W4 J3QKP1 D3XNU5 A0A0E3XJU3 A0A0U2ZQU7 A0A140HMB1 B3GN61 H3BNC6 ENST00000422392.6 [P12830-2] P12830 ENST00000566612.5 A0A3G2JNR5 ENST00000561751.1 ENST00000566510.5 A0A6C0N5X1 ENST00000261769.10 [P12830-1]

CDH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review