CCDC115 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905146Biological processlysosomal protein catabolic process
GO_0036295Biological processcellular response to increased oxygen levels
GO_0006879Biological processintracellular iron ion homeostasis
GO_0070072Biological processvacuolar proton-transporting V-type ATPase complex assembly
GO_0007042Biological processlysosomal lumen acidification
GO_0005764Cellular componentlysosome
GO_0005768Cellular componentendosome
GO_0005783Cellular componentendoplasmic reticulum
GO_0016471Cellular componentvacuolar proton-transporting V-type ATPase complex
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0030137Cellular componentCOPI-coated vesicle
GO_0016020Cellular componentmembrane
GO_0051082Molecular functionunfolded protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCCDC115
Protein nameCoiled-coil domain containing 115
Coiled-coil domain-containing protein 115
SynonymshCG_39080
MGC12981
DescriptionFUNCTION: Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation . May be involved in Golgi homeostasis . .

AccessionsENST00000442217.5
ENST00000651709.1 [Q96NT0-2]
ENST00000409127.1
ENST00000259229.7 [Q96NT0-1]
Q96NT0
F8WCZ3
B8ZZ99