CAPG | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	27 studies	52% ± 22%	Explore
B cell	26 studies	31% ± 10%	Explore
classical monocyte	26 studies	54% ± 16%	Explore
mast cell	25 studies	63% ± 18%	Explore
conventional dendritic cell	25 studies	57% ± 19%	Explore
plasmacytoid dendritic cell	23 studies	59% ± 17%	Explore
dendritic cell	20 studies	49% ± 21%	Explore
monocyte	20 studies	45% ± 16%	Explore
memory B cell	19 studies	32% ± 12%	Explore
epithelial cell	16 studies	38% ± 22%	Explore
basal cell	15 studies	32% ± 15%	Explore
myeloid cell	14 studies	55% ± 22%	Explore
CD4-positive, alpha-beta T cell	12 studies	25% ± 8%	Explore
naive B cell	11 studies	23% ± 9%	Explore
non-classical monocyte	11 studies	29% ± 14%	Explore
CD8-positive, alpha-beta T cell	10 studies	25% ± 12%	Explore
alveolar macrophage	8 studies	62% ± 30%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	31% ± 8%	Explore
type I pneumocyte	7 studies	24% ± 8%	Explore
fibroblast	7 studies	19% ± 2%	Explore
neutrophil	7 studies	41% ± 16%	Explore
natural killer cell	7 studies	31% ± 21%	Explore
club cell	6 studies	25% ± 5%	Explore
secretory cell	6 studies	32% ± 11%	Explore
kidney loop of Henle epithelial cell	6 studies	27% ± 14%	Explore
T cell	6 studies	22% ± 6%	Explore
leukocyte	6 studies	31% ± 9%	Explore
gamma-delta T cell	6 studies	37% ± 11%	Explore
abnormal cell	6 studies	29% ± 12%	Explore
innate lymphoid cell	6 studies	28% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	23% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	29% ± 14%	Explore
mononuclear phagocyte	5 studies	37% ± 13%	Explore
hematopoietic precursor cell	5 studies	45% ± 28%	Explore
renal alpha-intercalated cell	5 studies	68% ± 8%	Explore
ciliated cell	5 studies	26% ± 11%	Explore
mature NK T cell	5 studies	26% ± 6%	Explore
monocyte-derived dendritic cell	4 studies	51% ± 22%	Explore
immature B cell	4 studies	48% ± 20%	Explore
microglial cell	4 studies	45% ± 22%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	25% ± 9%	Explore
intermediate monocyte	4 studies	61% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	40% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	24% ± 4%	Explore
group 3 innate lymphoid cell	4 studies	38% ± 17%	Explore
regulatory T cell	4 studies	19% ± 3%	Explore
duct epithelial cell	3 studies	20% ± 4%	Explore
plasmablast	3 studies	37% ± 22%	Explore
connective tissue cell	3 studies	33% ± 19%	Explore
epithelial cell of proximal tubule	3 studies	19% ± 3%	Explore
extravillous trophoblast	3 studies	42% ± 12%	Explore
plasma cell	3 studies	28% ± 14%	Explore
granulocyte	3 studies	68% ± 20%	Explore
goblet cell	3 studies	20% ± 1%	Explore
keratinocyte	3 studies	26% ± 2%	Explore
T-helper 17 cell	3 studies	21% ± 3%	Explore
hematopoietic stem cell	3 studies	19% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	27% ± 11%	Explore
peripheral blood	13 studies	26% ± 9%	Explore
kidney	4 studies	26% ± 5%	Explore
uterus	4 studies	27% ± 11%	Explore
intestine	4 studies	19% ± 4%	Explore
placenta	3 studies	24% ± 4%	Explore
breast	3 studies	20% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	6627.21	653 / 653	98%	382.53	593 / 605
breast	100%	3927.79	457 / 459	98%	287.29	1091 / 1118
lung	100%	8214.93	577 / 578	97%	261.50	1120 / 1155
kidney	100%	5973.24	89 / 89	96%	274.97	862 / 901
uterus	98%	2276.62	166 / 170	96%	365.40	442 / 459
bladder	86%	3743.43	18 / 21	97%	363.07	491 / 504
stomach	87%	2095.87	314 / 359	93%	175.81	266 / 286
skin	100%	6595.61	1800 / 1809	76%	432.77	360 / 472
esophagus	81%	4230.81	1176 / 1445	92%	132.53	169 / 183
intestine	69%	1668.35	669 / 966	97%	220.29	512 / 527
prostate	97%	2922.87	237 / 245	50%	45.06	249 / 502
pancreas	46%	703.23	152 / 328	95%	369.03	169 / 178
ovary	31%	431.78	55 / 180	97%	162.15	415 / 430
brain	59%	1037.75	1546 / 2642	59%	96.25	415 / 705
lymph node	0%	0	0 / 0	100%	696.41	29 / 29
tonsil	0%	0	0 / 0	100%	409.26	45 / 45
ureter	0%	0	0 / 0	100%	203.03	1 / 1
peripheral blood	99%	9385.96	921 / 929	0%	0	0 / 0
adipose	97%	3179.64	1169 / 1204	0%	0	0 / 0
blood vessel	92%	2817.37	1223 / 1335	0%	0	0 / 0
spleen	91%	2146.07	220 / 241	0%	0	0 / 0
adrenal gland	58%	865.49	149 / 258	9%	9.04	21 / 230
liver	3%	47.78	6 / 226	33%	37.92	132 / 406
eye	0%	0	0 / 0	21%	18.89	17 / 80
muscle	11%	145.85	91 / 803	0%	0	0 / 0
heart	11%	137.43	95 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0071803	Biological process	positive regulation of podosome assembly
GO_0051016	Biological process	barbed-end actin filament capping
GO_0030031	Biological process	cell projection assembly
GO_0022617	Biological process	extracellular matrix disassembly
GO_0008154	Biological process	actin polymerization or depolymerization
GO_0065003	Biological process	protein-containing complex assembly
GO_0051014	Biological process	actin filament severing
GO_0007417	Biological process	central nervous system development
GO_0001726	Cellular component	ruffle
GO_0005730	Cellular component	nucleolus
GO_0072686	Cellular component	mitotic spindle
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005814	Cellular component	centriole
GO_0090543	Cellular component	Flemming body
GO_0015629	Cellular component	actin cytoskeleton
GO_0005737	Cellular component	cytoplasm
GO_0008290	Cellular component	F-actin capping protein complex
GO_0030027	Cellular component	lamellipodium
GO_0042470	Cellular component	melanosome
GO_0005634	Cellular component	nucleus
GO_0019904	Molecular function	protein domain specific binding
GO_0044877	Molecular function	protein-containing complex binding
GO_0045296	Molecular function	cadherin binding
GO_0005546	Molecular function	phosphatidylinositol-4,5-bisphosphate binding
GO_0051015	Molecular function	actin filament binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CAPG
Protein name	Capping actin protein, gelsolin like Macrophage-capping protein (Actin regulatory protein CAP-G)
Synonyms	MCP AFCP
Description	FUNCTION: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
Accessions	B8ZZL6 ENST00000263867.9 [P40121-1] ENST00000409275.1 ENST00000449030.5 ENST00000439385.5 ENST00000409670.5 [P40121-1] ENST00000453973.5 P40121 A0A979HLS1 E7ENU9 A0A979HLS2 ENST00000409724.5 [P40121-1] H7C0X8 ENST00000447219.6 ENST00000409921.5 [P40121-2]

CAPG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review