BCAS3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0043627Biological processresponse to estrogen
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0071391Biological processcellular response to estrogen stimulus
GO_0043085Biological processpositive regulation of catalytic activity
GO_0007267Biological processcell-cell signaling
GO_0042594Biological processresponse to starvation
GO_0006914Biological processautophagy
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000791Cellular componenteuchromatin
GO_0031252Cellular componentcell leading edge
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0005881Cellular componentcytoplasmic microtubule
GO_0000407Cellular componentphagophore assembly site
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0010698Molecular functionacetyltransferase activator activity
GO_0016922Molecular functionnuclear receptor binding
GO_0048487Molecular functionbeta-tubulin binding
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0035035Molecular functionhistone acetyltransferase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBCAS3
Protein nameBreast carcinoma amplified sequence 3
BCAS3 microtubule associated cell migration factor
BCAS3 protein
BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1)
Synonyms
DescriptionFUNCTION: Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy . Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures . .

AccessionsK7EKB0
ENST00000588874.5 [Q9H6U6-6]
ENST00000407086.8 [Q9H6U6-2]
ENST00000590128.5
ENST00000390652.9 [Q9H6U6-1]
ENST00000586705.5
K7EJH7
ENST00000588462.5 [Q9H6U6-8]
ENST00000589222.5 [Q9H6U6-7]
ENST00000626960.2
ENST00000588532.5
K7EIE2
ENST00000585744.5
ENST00000592848.5
ENST00000586484.1
B7ZKU7
Q05D99
ENST00000408905.7 [Q9H6U6-3]
ENST00000588168.5
K7ELH0
K7ESE9
ENST00000586241.1
K7EJU7
Q9H6U6
K7EIR7
K7EQA6
ENST00000591147.5
K7EML5
ENST00000587002.1