BAIAP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	17 studies	30% ± 12%	Explore
endothelial cell	13 studies	25% ± 8%	Explore
type I pneumocyte	12 studies	32% ± 10%	Explore
basal cell	11 studies	32% ± 14%	Explore
glutamatergic neuron	8 studies	40% ± 17%	Explore
epithelial cell	8 studies	32% ± 17%	Explore
type II pneumocyte	7 studies	25% ± 6%	Explore
capillary endothelial cell	7 studies	27% ± 8%	Explore
club cell	5 studies	21% ± 5%	Explore
squamous epithelial cell	4 studies	46% ± 22%	Explore
neuron	4 studies	19% ± 3%	Explore
endothelial cell of lymphatic vessel	4 studies	19% ± 4%	Explore
GABAergic neuron	4 studies	27% ± 10%	Explore
vein endothelial cell	4 studies	20% ± 4%	Explore
plasmacytoid dendritic cell	4 studies	23% ± 7%	Explore
fibroblast	3 studies	18% ± 1%	Explore
dendritic cell	3 studies	27% ± 6%	Explore
macrophage	3 studies	20% ± 3%	Explore
secretory cell	3 studies	32% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	30% ± 14%	Explore
lung	5 studies	22% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	6541.19	245 / 245	100%	49.97	502 / 502
thymus	100%	3103.20	650 / 653	97%	19.73	586 / 605
esophagus	100%	6019.51	1439 / 1445	97%	26.85	177 / 183
uterus	100%	2959.53	170 / 170	95%	20.41	438 / 459
lung	100%	5536.16	576 / 578	95%	17.85	1100 / 1155
breast	98%	2853.23	450 / 459	97%	18.41	1082 / 1118
brain	95%	5271.85	2512 / 2642	99%	18.31	700 / 705
bladder	100%	2054.00	21 / 21	89%	13.70	451 / 504
skin	91%	8770.99	1647 / 1809	98%	21.92	462 / 472
liver	100%	4503.53	226 / 226	89%	12.83	360 / 406
stomach	100%	4826.79	359 / 359	86%	9.43	245 / 286
intestine	89%	2900.08	857 / 966	90%	10.33	476 / 527
kidney	98%	2913.76	87 / 89	79%	8.00	710 / 901
ovary	74%	1092.45	134 / 180	100%	22.54	429 / 430
pancreas	8%	101.91	26 / 328	94%	14.64	168 / 178
eye	0%	0	0 / 0	100%	28.75	80 / 80
tonsil	0%	0	0 / 0	100%	28.63	45 / 45
ureter	0%	0	0 / 0	100%	10.43	1 / 1
adrenal gland	28%	375.30	71 / 258	71%	17.88	164 / 230
adipose	95%	2289.36	1145 / 1204	0%	0	0 / 0
heart	70%	1235.72	599 / 861	0%	0	0 / 0
spleen	65%	914.04	157 / 241	0%	0	0 / 0
blood vessel	25%	379.67	340 / 1335	0%	0	0 / 0
muscle	19%	282.56	154 / 803	0%	0	0 / 0
peripheral blood	3%	37.05	25 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030838	Biological process	positive regulation of actin filament polymerization
GO_0061003	Biological process	positive regulation of dendritic spine morphogenesis
GO_0071364	Biological process	cellular response to epidermal growth factor stimulus
GO_1905274	Biological process	regulation of modification of postsynaptic actin cytoskeleton
GO_2000463	Biological process	positive regulation of excitatory postsynaptic potential
GO_0007409	Biological process	axonogenesis
GO_0051017	Biological process	actin filament bundle assembly
GO_0048167	Biological process	regulation of synaptic plasticity
GO_0008286	Biological process	insulin receptor signaling pathway
GO_0051764	Biological process	actin crosslink formation
GO_0007009	Biological process	plasma membrane organization
GO_0008360	Biological process	regulation of cell shape
GO_1905232	Biological process	cellular response to L-glutamate
GO_0035418	Biological process	protein localization to synapse
GO_0016358	Biological process	dendrite development
GO_0098609	Biological process	cell-cell adhesion
GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_0001726	Cellular component	ruffle
GO_0061846	Cellular component	dendritic spine cytoplasm
GO_0098978	Cellular component	glutamatergic synapse
GO_0098685	Cellular component	Schaffer collateral - CA1 synapse
GO_0005886	Cellular component	plasma membrane
GO_0005874	Cellular component	microtubule
GO_0043198	Cellular component	dendritic shaft
GO_0097060	Cellular component	synaptic membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0043025	Cellular component	neuronal cell body
GO_0030175	Cellular component	filopodium
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005912	Cellular component	adherens junction
GO_0099524	Cellular component	postsynaptic cytosol
GO_0005737	Cellular component	cytoplasm
GO_0060076	Cellular component	excitatory synapse
GO_0099523	Cellular component	presynaptic cytosol
GO_0030141	Cellular component	secretory granule
GO_0061845	Cellular component	neuron projection branch point
GO_0030027	Cellular component	lamellipodium
GO_0044306	Cellular component	neuron projection terminus
GO_0099092	Cellular component	postsynaptic density, intracellular component
GO_0070064	Molecular function	proline-rich region binding
GO_0001221	Molecular function	transcription coregulator binding
GO_0042802	Molecular function	identical protein binding
GO_0030165	Molecular function	PDZ domain binding
GO_0097110	Molecular function	scaffold protein binding
GO_0098641	Molecular function	cadherin binding involved in cell-cell adhesion
GO_0008093	Molecular function	cytoskeletal anchor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	BAIAP2
Protein name	BAR/IMD domain containing adaptor protein 2 (cDNA FLJ55181, highly similar to Brain-specific angiogenesis inhibitor1-associated protein 2) Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) Brain-specific angiogenesis inhibitor 1-associated protein 2 BAR/IMD domain containing adaptor protein 2
Synonyms
Description	FUNCTION: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. . FUNCTION: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. .
Accessions	I3L526 I3L3C5 I3L0M4 ENST00000576756.5 I3L4A3 I3L0Y9 ENST00000575712.5 [Q9UQB8-3] I3L3C6 ENST00000321300.10 [Q9UQB8-1] ENST00000573677.5 ENST00000575841.5 I3L3J7 ENST00000573659.5 ENST00000572073.5 ENST00000321280.11 [Q9UQB8-4] ENST00000428708.7 [Q9UQB8-2] I3L2M4 Q9UQB8 I3L113 I3L4C2 ENST00000572918.5 ENST00000575245.5 ENST00000575958.5 I3L327 ENST00000572498.1 ENST00000575989.5 ENST00000572329.5 I3L2J6 ENST00000575750.5 ENST00000571530.5 B4DWA1 ENST00000435091.7 [Q9UQB8-5] ENST00000574804.5 I3L1C8 I3L125 ENST00000416299.6

BAIAP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review