ATXN7L3B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	13 studies	34% ± 9%	Explore
natural killer cell	12 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	22% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	22% ± 4%	Explore
fibroblast	9 studies	21% ± 5%	Explore
endothelial cell	9 studies	23% ± 6%	Explore
B cell	8 studies	21% ± 6%	Explore
naive B cell	8 studies	21% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	21% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	21% ± 5%	Explore
epithelial cell	7 studies	32% ± 13%	Explore
glutamatergic neuron	7 studies	32% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	19% ± 4%	Explore
CD4-positive, alpha-beta T cell	6 studies	22% ± 4%	Explore
CD8-positive, alpha-beta T cell	6 studies	20% ± 2%	Explore
mature NK T cell	6 studies	18% ± 3%	Explore
neuron	6 studies	27% ± 12%	Explore
mucosal invariant T cell	6 studies	16% ± 1%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	19% ± 2%	Explore
gamma-delta T cell	6 studies	25% ± 13%	Explore
regulatory T cell	6 studies	18% ± 2%	Explore
plasmacytoid dendritic cell	6 studies	21% ± 3%	Explore
GABAergic neuron	5 studies	30% ± 9%	Explore
T cell	4 studies	21% ± 2%	Explore
hematopoietic precursor cell	4 studies	33% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
abnormal cell	4 studies	25% ± 8%	Explore
hematopoietic stem cell	4 studies	28% ± 9%	Explore
pro-B cell	4 studies	30% ± 5%	Explore
smooth muscle cell	4 studies	20% ± 3%	Explore
amacrine cell	4 studies	34% ± 13%	Explore
oligodendrocyte precursor cell	4 studies	29% ± 4%	Explore
goblet cell	4 studies	20% ± 3%	Explore
oligodendrocyte	4 studies	24% ± 2%	Explore
interneuron	4 studies	35% ± 13%	Explore
type I pneumocyte	3 studies	21% ± 4%	Explore
ionocyte	3 studies	23% ± 4%	Explore
classical monocyte	3 studies	21% ± 2%	Explore
non-classical monocyte	3 studies	23% ± 4%	Explore
retinal bipolar neuron	3 studies	28% ± 5%	Explore
retinal ganglion cell	3 studies	52% ± 19%	Explore
precursor B cell	3 studies	23% ± 2%	Explore
immature B cell	3 studies	20% ± 1%	Explore
retinal cone cell	3 studies	32% ± 5%	Explore
retinal rod cell	3 studies	23% ± 2%	Explore
Mueller cell	3 studies	29% ± 10%	Explore
basal cell	3 studies	30% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	20% ± 4%	Explore
innate lymphoid cell	3 studies	19% ± 1%	Explore
connective tissue cell	3 studies	23% ± 5%	Explore
enteroendocrine cell	3 studies	24% ± 9%	Explore
intestinal crypt stem cell	3 studies	21% ± 4%	Explore
pericyte	3 studies	20% ± 2%	Explore
T follicular helper cell	3 studies	21% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	7 studies	29% ± 9%	Explore
peripheral blood	6 studies	23% ± 8%	Explore
lung	5 studies	22% ± 7%	Explore
intestine	4 studies	21% ± 5%	Explore
eye	3 studies	30% ± 3%	Explore
bone marrow	3 studies	21% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	8491.54	2642 / 2642	100%	76.63	705 / 705
breast	100%	4628.02	459 / 459	100%	74.63	1118 / 1118
prostate	100%	5353.33	245 / 245	100%	72.40	502 / 502
esophagus	100%	4185.24	1444 / 1445	100%	50.25	183 / 183
lung	100%	4309.60	578 / 578	100%	51.91	1154 / 1155
intestine	100%	5071.83	966 / 966	100%	47.67	526 / 527
stomach	100%	7500.74	359 / 359	100%	50.69	285 / 286
skin	100%	5257.17	1809 / 1809	100%	58.53	470 / 472
ovary	100%	6036.54	180 / 180	100%	57.98	428 / 430
thymus	100%	5596.75	653 / 653	100%	60.53	602 / 605
bladder	100%	4400.76	21 / 21	99%	47.74	501 / 504
kidney	100%	4780.09	89 / 89	99%	47.42	893 / 901
adrenal gland	100%	4741.39	258 / 258	99%	56.98	227 / 230
pancreas	100%	3583.02	327 / 328	99%	48.72	176 / 178
uterus	100%	5504.34	170 / 170	98%	45.31	451 / 459
liver	100%	2877.80	226 / 226	93%	29.15	376 / 406
adipose	100%	3813.80	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	48.46	80 / 80
lymph node	0%	0	0 / 0	100%	36.95	29 / 29
muscle	100%	3531.89	803 / 803	0%	0	0 / 0
spleen	100%	5478.46	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	36.20	45 / 45
ureter	0%	0	0 / 0	100%	37.65	1 / 1
blood vessel	100%	3508.88	1334 / 1335	0%	0	0 / 0
heart	97%	3047.27	835 / 861	0%	0	0 / 0
peripheral blood	82%	2604.05	761 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010468	Biological process	regulation of gene expression
GO_0005737	Cellular component	cytoplasm
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ATXN7L3B
Protein name	Ataxin-7-like protein 3B
Synonyms
Description	FUNCTION: By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3. .
Accessions	ENST00000519948.4 Q96GX2

ATXN7L3B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review