ATR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006139Biological processnucleobase-containing compound metabolic process
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0006281Biological processDNA repair
GO_0036297Biological processinterstrand cross-link repair
GO_2000779Biological processregulation of double-strand break repair
GO_0034644Biological processcellular response to UV
GO_0006302Biological processdouble-strand break repair
GO_0006974Biological processDNA damage response
GO_0097695Biological processestablishment of protein-containing complex localization to telomere
GO_0090399Biological processreplicative senescence
GO_0046685Biological processresponse to arsenic-containing substance
GO_0006260Biological processDNA replication
GO_0006338Biological processchromatin remodeling
GO_0097694Biological processestablishment of RNA localization to telomere
GO_0071480Biological processcellular response to gamma radiation
GO_1900034Biological processregulation of cellular response to heat
GO_0043517Biological processpositive regulation of DNA damage response, signal transduction by p53 class mediator
GO_0044818Biological processmitotic G2/M transition checkpoint
GO_0031297Biological processreplication fork processing
GO_0008156Biological processnegative regulation of DNA replication
GO_0070198Biological processprotein localization to chromosome, telomeric region
GO_0000723Biological processtelomere maintenance
GO_0051081Biological processnuclear membrane disassembly
GO_0009612Biological processresponse to mechanical stimulus
GO_0009410Biological processresponse to xenobiotic stimulus
GO_1904884Biological processpositive regulation of telomerase catalytic core complex assembly
GO_0046777Biological processprotein autophosphorylation
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0000077Biological processDNA damage checkpoint signaling
GO_0070310Cellular componentATR-ATRIP complex
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005635Cellular componentnuclear envelope
GO_0090734Cellular componentsite of DNA damage
GO_0016605Cellular componentPML body
GO_0005694Cellular componentchromosome
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0032407Molecular functionMutSalpha complex binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0032405Molecular functionMutLalpha complex binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0035979Molecular functionhistone H2AXS139 kinase activity

IV. Literature review

[source]
Gene nameATR
Protein nameSerine/threonine-protein kinase ATR (EC 2.7.11.1)
ATR serine/threonine kinase
Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)
SynonymsFRP1
DescriptionFUNCTION: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor . Recognizes the substrate consensus sequence [ST]-Q . Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis . Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism . Required for FANCD2 ubiquitination . Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication . Acts as a regulator of the S-G2 transition by restricting the activity of CDK1 during S-phase to prevent premature entry into G2 . Acts as a regulator of the nuclear envelope integrity in response to DNA damage and stress . Acts as a mechanical stress sensor at the nuclear envelope: relocalizes to the nuclear envelope in response to mechanical stress and mediates a checkpoint via phosphorylation of CHEK1 . Also promotes nuclear envelope rupture in response to DNA damage by mediating phosphorylation of LMNA at 'Ser-282', leading to lamin disassembly . Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at 'Ser-395', priming LMNA for subsequent phosphorylation by CDK1 and micronuclei envelope rupture . The rupture of micronuclear envelope triggers the cGAS-STING pathway thereby activating the type I interferon response and innate immunity . Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity). .

AccessionsENST00000515149.3
ENST00000507148.1
ENST00000515810.1
D6RIG7
H0Y8R8
Q13535
ENST00000350721.9 [Q13535-1]
D6RFJ6
ENST00000661310.1 [Q13535-2]
ENST00000656590.1
A0A590UJ01