Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 29% ± 11% | |
microglial cell | 10 studies | 27% ± 10% | |
glutamatergic neuron | 9 studies | 43% ± 27% | |
oligodendrocyte precursor cell | 9 studies | 26% ± 11% | |
adipocyte | 9 studies | 31% ± 7% | |
oligodendrocyte | 9 studies | 27% ± 11% | |
astrocyte | 8 studies | 31% ± 14% | |
macrophage | 8 studies | 28% ± 12% | |
dendritic cell | 7 studies | 21% ± 4% | |
ciliated cell | 7 studies | 25% ± 12% | |
epithelial cell | 6 studies | 30% ± 13% | |
fibroblast | 6 studies | 26% ± 6% | |
T cell | 6 studies | 20% ± 5% | |
GABAergic neuron | 6 studies | 49% ± 23% | |
interneuron | 5 studies | 46% ± 24% | |
B cell | 5 studies | 22% ± 7% | |
endothelial cell of lymphatic vessel | 5 studies | 26% ± 6% | |
smooth muscle cell | 5 studies | 18% ± 3% | |
cardiac muscle cell | 4 studies | 18% ± 2% | |
retinal cone cell | 4 studies | 31% ± 8% | |
myeloid cell | 4 studies | 27% ± 5% | |
pericyte | 4 studies | 26% ± 8% | |
type II pneumocyte | 4 studies | 19% ± 5% | |
neuron | 3 studies | 30% ± 12% | |
GABAergic interneuron | 3 studies | 22% ± 1% | |
plasma cell | 3 studies | 23% ± 4% | |
CD4-positive, alpha-beta T cell | 3 studies | 17% ± 1% | |
mesothelial cell | 3 studies | 22% ± 5% | |
retinal rod cell | 3 studies | 27% ± 6% | |
hepatocyte | 3 studies | 44% ± 33% | |
alveolar macrophage | 3 studies | 30% ± 8% | |
club cell | 3 studies | 25% ± 7% | |
monocyte | 3 studies | 31% ± 2% | |
natural killer cell | 3 studies | 23% ± 5% | |
type I pneumocyte | 3 studies | 22% ± 5% | |
lymphocyte | 3 studies | 34% ± 7% | |
transit amplifying cell | 3 studies | 39% ± 25% | |
mucus secreting cell | 3 studies | 25% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1534.00 | 1444 / 1445 | 100% | 8.46 | 183 / 183 |
breast | 100% | 2148.68 | 459 / 459 | 100% | 6.06 | 1113 / 1118 |
lung | 100% | 1875.73 | 577 / 578 | 100% | 5.11 | 1151 / 1155 |
ovary | 100% | 1729.72 | 180 / 180 | 99% | 2.85 | 425 / 430 |
bladder | 100% | 1753.71 | 21 / 21 | 99% | 4.40 | 498 / 504 |
prostate | 100% | 1950.97 | 245 / 245 | 99% | 4.34 | 495 / 502 |
intestine | 100% | 1725.84 | 966 / 966 | 98% | 4.32 | 519 / 527 |
stomach | 100% | 1370.62 | 359 / 359 | 98% | 4.95 | 281 / 286 |
thymus | 100% | 2494.15 | 653 / 653 | 98% | 3.67 | 594 / 605 |
uterus | 100% | 2152.26 | 170 / 170 | 98% | 4.75 | 450 / 459 |
pancreas | 100% | 1409.48 | 327 / 328 | 98% | 3.79 | 174 / 178 |
kidney | 100% | 1631.76 | 89 / 89 | 96% | 3.34 | 869 / 901 |
brain | 97% | 1254.57 | 2568 / 2642 | 99% | 3.00 | 698 / 705 |
adrenal gland | 100% | 4817.94 | 258 / 258 | 92% | 3.01 | 212 / 230 |
skin | 100% | 2268.15 | 1809 / 1809 | 92% | 3.99 | 433 / 472 |
liver | 100% | 1354.33 | 226 / 226 | 79% | 1.78 | 321 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 4.85 | 29 / 29 |
spleen | 100% | 2795.12 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 6.18 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 1.49 | 1 / 1 |
blood vessel | 100% | 1430.77 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 1851.12 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 98% | 904.53 | 790 / 803 | 0% | 0 | 0 / 0 |
heart | 96% | 963.97 | 827 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 71% | 1119.92 | 660 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 48% | 0.98 | 38 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006139 | Biological process | nucleobase-containing compound metabolic process |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0006281 | Biological process | DNA repair |
GO_0036297 | Biological process | interstrand cross-link repair |
GO_2000779 | Biological process | regulation of double-strand break repair |
GO_0034644 | Biological process | cellular response to UV |
GO_0006302 | Biological process | double-strand break repair |
GO_0006974 | Biological process | DNA damage response |
GO_0097695 | Biological process | establishment of protein-containing complex localization to telomere |
GO_0090399 | Biological process | replicative senescence |
GO_0046685 | Biological process | response to arsenic-containing substance |
GO_0006260 | Biological process | DNA replication |
GO_0006338 | Biological process | chromatin remodeling |
GO_0097694 | Biological process | establishment of RNA localization to telomere |
GO_0071480 | Biological process | cellular response to gamma radiation |
GO_1900034 | Biological process | regulation of cellular response to heat |
GO_0043517 | Biological process | positive regulation of DNA damage response, signal transduction by p53 class mediator |
GO_0044818 | Biological process | mitotic G2/M transition checkpoint |
GO_0031297 | Biological process | replication fork processing |
GO_0008156 | Biological process | negative regulation of DNA replication |
GO_0070198 | Biological process | protein localization to chromosome, telomeric region |
GO_0000723 | Biological process | telomere maintenance |
GO_0051081 | Biological process | nuclear membrane disassembly |
GO_0009612 | Biological process | response to mechanical stimulus |
GO_0009410 | Biological process | response to xenobiotic stimulus |
GO_1904884 | Biological process | positive regulation of telomerase catalytic core complex assembly |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0032212 | Biological process | positive regulation of telomere maintenance via telomerase |
GO_0000077 | Biological process | DNA damage checkpoint signaling |
GO_0070310 | Cellular component | ATR-ATRIP complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005635 | Cellular component | nuclear envelope |
GO_0090734 | Cellular component | site of DNA damage |
GO_0016605 | Cellular component | PML body |
GO_0005694 | Cellular component | chromosome |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0032407 | Molecular function | MutSalpha complex binding |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0032405 | Molecular function | MutLalpha complex binding |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0004672 | Molecular function | protein kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
GO_0035979 | Molecular function | histone H2AXS139 kinase activity |
Gene name | ATR |
Protein name | Serine/threonine-protein kinase ATR (EC 2.7.11.1) ATR serine/threonine kinase Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) |
Synonyms | FRP1 |
Description | FUNCTION: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor . Recognizes the substrate consensus sequence [ST]-Q . Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis . Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism . Required for FANCD2 ubiquitination . Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication . Acts as a regulator of the S-G2 transition by restricting the activity of CDK1 during S-phase to prevent premature entry into G2 . Acts as a regulator of the nuclear envelope integrity in response to DNA damage and stress . Acts as a mechanical stress sensor at the nuclear envelope: relocalizes to the nuclear envelope in response to mechanical stress and mediates a checkpoint via phosphorylation of CHEK1 . Also promotes nuclear envelope rupture in response to DNA damage by mediating phosphorylation of LMNA at 'Ser-282', leading to lamin disassembly . Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at 'Ser-395', priming LMNA for subsequent phosphorylation by CDK1 and micronuclei envelope rupture . The rupture of micronuclear envelope triggers the cGAS-STING pathway thereby activating the type I interferon response and innate immunity . Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity). . |
Accessions | ENST00000515149.3 ENST00000507148.1 ENST00000515810.1 D6RIG7 H0Y8R8 Q13535 ENST00000350721.9 [Q13535-1] D6RFJ6 ENST00000661310.1 [Q13535-2] ENST00000656590.1 A0A590UJ01 |