ATG5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0055015Biological processventricular cardiac muscle cell development
GO_0016567Biological processprotein ubiquitination
GO_0001974Biological processblood vessel remodeling
GO_0000045Biological processautophagosome assembly
GO_0010040Biological processresponse to iron(II) ion
GO_1901096Biological processregulation of autophagosome maturation
GO_0071500Biological processcellular response to nitrosative stress
GO_0062029Biological processpositive regulation of stress granule assembly
GO_0034727Biological processpiecemeal microautophagy of the nucleus
GO_0009620Biological processresponse to fungus
GO_0016236Biological processmacroautophagy
GO_2000378Biological processnegative regulation of reactive oxygen species metabolic process
GO_0035973Biological processaggrephagy
GO_1902017Biological processregulation of cilium assembly
GO_0043687Biological processpost-translational protein modification
GO_0051649Biological processestablishment of localization in cell
GO_0039689Biological processnegative stranded viral RNA replication
GO_0032480Biological processnegative regulation of type I interferon production
GO_1904973Biological processpositive regulation of viral translation
GO_0045824Biological processnegative regulation of innate immune response
GO_0019883Biological processantigen processing and presentation of endogenous antigen
GO_0050765Biological processnegative regulation of phagocytosis
GO_0048840Biological processotolith development
GO_0060047Biological processheart contraction
GO_0061684Biological processchaperone-mediated autophagy
GO_0050687Biological processnegative regulation of defense response to virus
GO_0010659Biological processcardiac muscle cell apoptotic process
GO_0000422Biological processautophagy of mitochondrion
GO_0051279Biological processregulation of release of sequestered calcium ion into cytosol
GO_0000423Biological processmitophagy
GO_0006914Biological processautophagy
GO_0045060Biological processnegative thymic T cell selection
GO_0010667Biological processnegative regulation of cardiac muscle cell apoptotic process
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0070254Biological processmucus secretion
GO_0042311Biological processvasodilation
GO_0006995Biological processcellular response to nitrogen starvation
GO_0061739Biological processprotein lipidation involved in autophagosome assembly
GO_1902617Biological processresponse to fluoride
GO_0002718Biological processregulation of cytokine production involved in immune response
GO_0070257Biological processpositive regulation of mucus secretion
GO_1904093Biological processnegative regulation of autophagic cell death
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0016020Cellular componentmembrane
GO_0034045Cellular componentphagophore assembly site membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005930Cellular componentaxoneme
GO_0044233Cellular componentmitochondria-associated endoplasmic reticulum membrane contact site
GO_0005829Cellular componentcytosol
GO_1990234Cellular componenttransferase complex
GO_0005776Cellular componentautophagosome
GO_0005737Cellular componentcytoplasm
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0061908Cellular componentphagophore
GO_0034274Cellular componentAtg12-Atg5-Atg16 complex
GO_0030424Cellular componentaxon
GO_0019776Molecular functionAtg8-family ligase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATG5
Protein nameAutophagy protein 5 (APG5-like) (Apoptosis-specific protein)
ATG5 variant 2 (Autophagy related 5)
Autophagy protein 5
ATG5 variant 3 (Autophagy related 5)
Autophagy related 5
SynonymsDKFZp686F0183
APG5L
ASP
hCG_32959
DescriptionFUNCTION: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. .; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. .

FUNCTION: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. .; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. .; FUNCTION: (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection . Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established . .

FUNCTION: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. .; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. .

FUNCTION: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. .; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. .

FUNCTION: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. .; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. .

FUNCTION: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. .; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. .

AccessionsENST00000613993.1
ENST00000635758.2 [Q9H1Y0-2]
ENST00000636437.1
ENST00000369076.8 [Q9H1Y0-1]
ENST00000636335.1
ENST00000360666.6
ENST00000646025.1
A0A2R8Y718
L7UMD8
Q7Z3H3
ENST00000369070.5
L7UQJ2
ENST00000343245.7 [Q9H1Y0-1]
Q9H1Y0
A0A1B0GUS1
A0A1B0GV54
A9UGY9