ASCC3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	24 studies	30% ± 12%	Explore
astrocyte	13 studies	31% ± 17%	Explore
microglial cell	13 studies	36% ± 12%	Explore
oligodendrocyte precursor cell	12 studies	36% ± 13%	Explore
fibroblast	12 studies	31% ± 11%	Explore
oligodendrocyte	12 studies	31% ± 13%	Explore
natural killer cell	10 studies	22% ± 4%	Explore
glutamatergic neuron	10 studies	51% ± 24%	Explore
pericyte	10 studies	25% ± 9%	Explore
epithelial cell	10 studies	31% ± 16%	Explore
macrophage	10 studies	30% ± 13%	Explore
GABAergic neuron	9 studies	47% ± 24%	Explore
basal cell	9 studies	35% ± 18%	Explore
B cell	7 studies	23% ± 8%	Explore
CD8-positive, alpha-beta T cell	7 studies	19% ± 4%	Explore
adipocyte	7 studies	27% ± 8%	Explore
T cell	6 studies	25% ± 7%	Explore
CD4-positive, alpha-beta T cell	6 studies	20% ± 4%	Explore
interneuron	6 studies	49% ± 24%	Explore
mucosal invariant T cell	6 studies	19% ± 4%	Explore
club cell	6 studies	35% ± 14%	Explore
dendritic cell	6 studies	24% ± 4%	Explore
mast cell	6 studies	23% ± 8%	Explore
ciliated cell	6 studies	27% ± 5%	Explore
type I pneumocyte	6 studies	32% ± 11%	Explore
type II pneumocyte	6 studies	28% ± 8%	Explore
regulatory T cell	6 studies	19% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	20% ± 3%	Explore
neuron	5 studies	41% ± 18%	Explore
myeloid cell	5 studies	27% ± 6%	Explore
respiratory goblet cell	5 studies	33% ± 13%	Explore
endothelial cell of lymphatic vessel	5 studies	31% ± 7%	Explore
smooth muscle cell	5 studies	28% ± 6%	Explore
granule cell	4 studies	36% ± 9%	Explore
plasma cell	4 studies	37% ± 5%	Explore
cardiac muscle cell	4 studies	22% ± 2%	Explore
mesothelial cell	4 studies	33% ± 6%	Explore
lymphocyte	4 studies	38% ± 10%	Explore
amacrine cell	4 studies	35% ± 18%	Explore
monocyte	4 studies	29% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	17% ± 1%	Explore
hematopoietic precursor cell	3 studies	21% ± 4%	Explore
plasmablast	3 studies	26% ± 13%	Explore
GABAergic interneuron	3 studies	39% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	23% ± 4%	Explore
vein endothelial cell	3 studies	33% ± 18%	Explore
GABAergic amacrine cell	3 studies	32% ± 15%	Explore
glycinergic amacrine cell	3 studies	33% ± 10%	Explore
retina horizontal cell	3 studies	29% ± 12%	Explore
retinal ganglion cell	3 studies	38% ± 24%	Explore
endothelial cell of vascular tree	3 studies	31% ± 16%	Explore
hepatocyte	3 studies	59% ± 21%	Explore
abnormal cell	3 studies	31% ± 18%	Explore
connective tissue cell	3 studies	32% ± 10%	Explore
alveolar macrophage	3 studies	33% ± 7%	Explore
capillary endothelial cell	3 studies	20% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	21% ± 3%	Explore
gamma-delta T cell	3 studies	24% ± 8%	Explore
goblet cell	3 studies	38% ± 28%	Explore
transit amplifying cell	3 studies	43% ± 31%	Explore
mucus secreting cell	3 studies	29% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	38% ± 21%	Explore
lung	7 studies	25% ± 7%	Explore
heart	4 studies	24% ± 5%	Explore
eye	4 studies	33% ± 14%	Explore
liver	4 studies	31% ± 17%	Explore
intestine	3 studies	16% ± 1%	Explore
adipose	3 studies	32% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2172.06	1445 / 1445	100%	26.17	183 / 183
stomach	100%	1422.75	359 / 359	100%	18.47	286 / 286
lung	100%	2051.94	577 / 578	100%	18.11	1155 / 1155
intestine	100%	1884.09	966 / 966	100%	16.90	526 / 527
breast	100%	2137.64	459 / 459	99%	20.30	1106 / 1118
uterus	100%	2044.09	170 / 170	99%	16.18	453 / 459
thymus	100%	1688.17	653 / 653	99%	14.52	596 / 605
bladder	100%	2495.29	21 / 21	98%	15.60	496 / 504
brain	98%	1036.83	2597 / 2642	99%	15.27	701 / 705
prostate	100%	2340.74	245 / 245	97%	13.57	488 / 502
pancreas	99%	1343.52	325 / 328	98%	12.02	174 / 178
ovary	100%	1698.48	180 / 180	95%	8.40	409 / 430
kidney	100%	1120.34	89 / 89	94%	11.84	845 / 901
skin	100%	4308.56	1808 / 1809	93%	13.15	439 / 472
adrenal gland	100%	2319.12	258 / 258	91%	9.72	209 / 230
liver	100%	1609.81	225 / 226	90%	9.58	367 / 406
adipose	100%	1987.51	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2551.59	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	12.13	29 / 29
spleen	100%	1956.95	241 / 241	0%	0	0 / 0
muscle	100%	1387.80	799 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	19.90	44 / 45
heart	96%	1416.75	824 / 861	0%	0	0 / 0
peripheral blood	67%	1943.52	619 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	54%	3.80	43 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0032508	Biological process	DNA duplex unwinding
GO_0008283	Biological process	cell population proliferation
GO_1990116	Biological process	ribosome-associated ubiquitin-dependent protein catabolic process
GO_0072344	Biological process	rescue of stalled ribosome
GO_0032790	Biological process	ribosome disassembly
GO_0006307	Biological process	DNA alkylation repair
GO_0022626	Cellular component	cytosolic ribosome
GO_0016020	Cellular component	membrane
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0099053	Cellular component	activating signal cointegrator 1 complex
GO_0005829	Cellular component	cytosol
GO_1990391	Cellular component	DNA repair complex
GO_0005634	Cellular component	nucleus
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity
GO_0043138	Molecular function	3'-5' DNA helicase activity

IV. Literature review

[source]

Gene name	ASCC3
Protein name	Activating signal cointegrator 1 complex subunit 3 Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200)
Synonyms	HELIC1 RQT2
Description	FUNCTION: ATPase involved both in DNA repair and rescue of stalled ribosomes . 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions . Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation . Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex . Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation . .
Accessions	ENST00000369143.2 [Q8N3C0-3] Q8N3C0 E5RFZ0 ENST00000369162.7 [Q8N3C0-1] J3KNJ4 ENST00000324696.8 ENST00000522650.5 [Q8N3C0-4] ENST00000324723.10

ASCC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review