ARRDC3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	32 studies	32% ± 14%	Explore
fibroblast	24 studies	31% ± 13%	Explore
macrophage	21 studies	34% ± 14%	Explore
endothelial cell of vascular tree	12 studies	31% ± 17%	Explore
natural killer cell	11 studies	22% ± 7%	Explore
pericyte	11 studies	29% ± 10%	Explore
monocyte	10 studies	23% ± 9%	Explore
basal cell	9 studies	31% ± 13%	Explore
dendritic cell	8 studies	23% ± 8%	Explore
type II pneumocyte	8 studies	28% ± 8%	Explore
classical monocyte	8 studies	24% ± 7%	Explore
conventional dendritic cell	8 studies	26% ± 7%	Explore
CD8-positive, alpha-beta T cell	8 studies	19% ± 4%	Explore
myofibroblast cell	8 studies	25% ± 10%	Explore
connective tissue cell	8 studies	25% ± 7%	Explore
type I pneumocyte	7 studies	24% ± 7%	Explore
endothelial cell of artery	7 studies	24% ± 4%	Explore
vein endothelial cell	7 studies	28% ± 10%	Explore
myeloid cell	7 studies	25% ± 4%	Explore
capillary endothelial cell	7 studies	22% ± 5%	Explore
T cell	6 studies	26% ± 9%	Explore
leukocyte	6 studies	18% ± 4%	Explore
epithelial cell	6 studies	35% ± 8%	Explore
interneuron	6 studies	23% ± 8%	Explore
club cell	6 studies	24% ± 7%	Explore
B cell	5 studies	18% ± 2%	Explore
non-classical monocyte	5 studies	23% ± 7%	Explore
smooth muscle cell	5 studies	23% ± 6%	Explore
ciliated cell	5 studies	24% ± 6%	Explore
Mueller cell	5 studies	34% ± 15%	Explore
neuron	5 studies	25% ± 8%	Explore
GABAergic neuron	5 studies	22% ± 2%	Explore
mast cell	4 studies	17% ± 2%	Explore
mature NK T cell	4 studies	26% ± 5%	Explore
progenitor cell	4 studies	25% ± 4%	Explore
mesothelial cell	4 studies	33% ± 14%	Explore
retinal rod cell	4 studies	21% ± 5%	Explore
hepatocyte	4 studies	34% ± 15%	Explore
astrocyte	4 studies	21% ± 6%	Explore
glutamatergic neuron	4 studies	26% ± 6%	Explore
oligodendrocyte	4 studies	21% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	21% ± 5%	Explore
CD4-positive, alpha-beta T cell	3 studies	23% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	23% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	23% ± 9%	Explore
kidney loop of Henle epithelial cell	3 studies	27% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	29% ± 4%	Explore
glial cell	3 studies	28% ± 12%	Explore
microglial cell	3 studies	31% ± 9%	Explore
squamous epithelial cell	3 studies	34% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	25% ± 7%	Explore
mononuclear phagocyte	3 studies	34% ± 6%	Explore
tissue-resident macrophage	3 studies	26% ± 3%	Explore
lymphocyte	3 studies	24% ± 8%	Explore
respiratory goblet cell	3 studies	29% ± 16%	Explore
secretory cell	3 studies	29% ± 4%	Explore
acinar cell	3 studies	42% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	29% ± 8%	Explore
gamma-delta T cell	3 studies	33% ± 6%	Explore
regulatory T cell	3 studies	24% ± 2%	Explore
goblet cell	3 studies	32% ± 7%	Explore
adipocyte	3 studies	29% ± 14%	Explore
naive B cell	3 studies	21% ± 7%	Explore
oligodendrocyte precursor cell	3 studies	27% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	9 studies	27% ± 6%	Explore
brain	8 studies	21% ± 2%	Explore
eye	6 studies	24% ± 8%	Explore
intestine	5 studies	22% ± 6%	Explore
kidney	4 studies	20% ± 4%	Explore
liver	4 studies	16% ± 1%	Explore
peripheral blood	3 studies	20% ± 3%	Explore
placenta	3 studies	27% ± 10%	Explore
uterus	3 studies	21% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	8987.74	577 / 578	98%	94.33	1133 / 1155
thymus	100%	12541.81	653 / 653	97%	161.91	586 / 605
breast	98%	9941.63	451 / 459	96%	66.46	1073 / 1118
esophagus	98%	4375.06	1422 / 1445	96%	46.33	175 / 183
ovary	100%	13509.29	180 / 180	93%	48.53	402 / 430
uterus	96%	5422.89	164 / 170	97%	74.68	445 / 459
prostate	99%	6141.04	243 / 245	94%	60.18	472 / 502
kidney	100%	5479.44	89 / 89	92%	137.24	833 / 901
adrenal gland	100%	13142.94	258 / 258	90%	56.12	208 / 230
bladder	95%	4877.19	20 / 21	91%	50.89	458 / 504
intestine	97%	3691.27	934 / 966	88%	39.11	466 / 527
stomach	94%	2997.91	337 / 359	90%	39.66	256 / 286
skin	100%	6531.30	1802 / 1809	79%	57.10	375 / 472
liver	92%	5186.46	207 / 226	76%	31.62	310 / 406
brain	71%	2115.00	1872 / 2642	96%	48.27	675 / 705
pancreas	71%	2263.61	232 / 328	96%	59.96	170 / 178
adipose	99%	7532.87	1195 / 1204	0%	0	0 / 0
spleen	98%	3741.22	236 / 241	0%	0	0 / 0
blood vessel	96%	4693.69	1288 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	76.11	43 / 45
muscle	93%	4036.67	744 / 803	0%	0	0 / 0
peripheral blood	83%	3094.42	774 / 929	0%	0	0 / 0
heart	63%	2228.08	540 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	41%	9.82	12 / 29
eye	0%	0	0 / 0	36%	12.97	29 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0035332	Biological process	positive regulation of hippo signaling
GO_0090327	Biological process	negative regulation of locomotion involved in locomotory behavior
GO_0015031	Biological process	protein transport
GO_0060613	Biological process	fat pad development
GO_0120163	Biological process	negative regulation of cold-induced thermogenesis
GO_0031651	Biological process	negative regulation of heat generation
GO_0043588	Biological process	skin development
GO_0071878	Biological process	negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
GO_0031649	Biological process	heat generation
GO_0051443	Biological process	positive regulation of ubiquitin-protein transferase activity
GO_0005764	Cellular component	lysosome
GO_0005768	Cellular component	endosome
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005769	Cellular component	early endosome
GO_0031699	Molecular function	beta-3 adrenergic receptor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ARRDC3
Protein name	Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP)
Synonyms	KIAA1376
Description	FUNCTION: Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors . Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation . May recruit NEDD4 to ADRB2 . Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes . .
Accessions	Q96B67 ENST00000265138.4

ARRDC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review