ARHGAP4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
non-classical monocyte	21 studies	33% ± 16%	Explore
CD8-positive, alpha-beta T cell	20 studies	25% ± 8%	Explore
classical monocyte	20 studies	27% ± 13%	Explore
natural killer cell	19 studies	24% ± 7%	Explore
B cell	18 studies	26% ± 8%	Explore
macrophage	18 studies	28% ± 14%	Explore
T cell	17 studies	21% ± 4%	Explore
regulatory T cell	16 studies	26% ± 7%	Explore
memory B cell	15 studies	23% ± 5%	Explore
plasmacytoid dendritic cell	14 studies	35% ± 10%	Explore
CD4-positive, alpha-beta T cell	14 studies	27% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	29% ± 9%	Explore
naive B cell	11 studies	25% ± 5%	Explore
conventional dendritic cell	10 studies	27% ± 18%	Explore
monocyte	10 studies	25% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	27% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	26% ± 6%	Explore
myeloid cell	10 studies	26% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	25% ± 4%	Explore
gamma-delta T cell	9 studies	28% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	26% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	26% ± 6%	Explore
dendritic cell	8 studies	31% ± 18%	Explore
mucosal invariant T cell	8 studies	25% ± 4%	Explore
mature NK T cell	7 studies	29% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	27% ± 8%	Explore
T follicular helper cell	6 studies	23% ± 5%	Explore
hematopoietic precursor cell	5 studies	25% ± 10%	Explore
endothelial cell of artery	5 studies	19% ± 3%	Explore
microglial cell	5 studies	24% ± 7%	Explore
exhausted T cell	4 studies	26% ± 9%	Explore
leukocyte	4 studies	21% ± 2%	Explore
immature B cell	4 studies	33% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	28% ± 9%	Explore
lymphocyte	3 studies	25% ± 4%	Explore
precursor B cell	3 studies	33% ± 8%	Explore
pro-B cell	3 studies	29% ± 8%	Explore
tissue-resident macrophage	3 studies	22% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	24% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	22% ± 3%	Explore
intermediate monocyte	3 studies	41% ± 22%	Explore
group 3 innate lymphoid cell	3 studies	25% ± 10%	Explore
brush cell	3 studies	22% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	22% ± 1%	Explore
double negative thymocyte	3 studies	31% ± 10%	Explore
abnormal cell	3 studies	19% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	28% ± 10%	Explore
lymph node	4 studies	20% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
uterus	100%	2056.05	170 / 170	97%	41.22	446 / 459
kidney	99%	3657.85	88 / 89	96%	21.55	869 / 901
lung	100%	7740.59	578 / 578	92%	21.88	1062 / 1155
breast	100%	2926.96	459 / 459	88%	15.17	987 / 1118
adrenal gland	100%	2702.82	257 / 258	87%	18.56	199 / 230
bladder	100%	2341.10	21 / 21	84%	20.98	425 / 504
intestine	99%	4527.27	956 / 966	84%	27.97	445 / 527
thymus	98%	2375.60	640 / 653	85%	30.28	515 / 605
stomach	92%	1561.46	331 / 359	82%	20.44	234 / 286
prostate	99%	2506.49	242 / 245	74%	7.10	369 / 502
ovary	74%	943.98	133 / 180	96%	26.35	413 / 430
esophagus	91%	1497.07	1320 / 1445	73%	12.66	134 / 183
brain	71%	1243.14	1889 / 2642	92%	15.59	651 / 705
skin	45%	549.26	806 / 1809	94%	31.53	443 / 472
liver	65%	835.18	146 / 226	73%	15.93	298 / 406
pancreas	39%	466.03	129 / 328	90%	22.91	161 / 178
lymph node	0%	0	0 / 0	100%	138.65	29 / 29
peripheral blood	100%	20316.12	929 / 929	0%	0	0 / 0
spleen	100%	25994.84	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	9.18	1 / 1
adipose	100%	4008.19	1201 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	49.65	42 / 45
heart	89%	1315.63	766 / 861	0%	0	0 / 0
blood vessel	81%	1747.29	1075 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	59%	6.02	47 / 80
muscle	12%	120.74	100 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007266	Biological process	Rho protein signal transduction
GO_0030336	Biological process	negative regulation of cell migration
GO_0030517	Biological process	negative regulation of axon extension
GO_0051056	Biological process	regulation of small GTPase mediated signal transduction
GO_0007399	Biological process	nervous system development
GO_0007010	Biological process	cytoskeleton organization
GO_0010764	Biological process	negative regulation of fibroblast migration
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005874	Cellular component	microtubule
GO_0030426	Cellular component	growth cone
GO_0005737	Cellular component	cytoplasm
GO_0005515	Molecular function	protein binding
GO_0005096	Molecular function	GTPase activator activity

IV. Literature review

[source]

Gene name	ARHGAP4
Protein name	Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) ARHGAP4 ARHGAP4 protein Rho GTPase activating protein 4
Synonyms	RHOGAP4 hCG_39227 KIAA0131 RGC1
Description	FUNCTION: Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.
Accessions	C9J5M2 ENST00000350060.10 [P98171-1] ENST00000442172.1 Q6PJ34 E7EQN5 ENST00000700282.1 H7C120 P98171 ENST00000370016.5 S4R314 ENST00000442262.5 ENST00000418750.5 ENST00000404127.6 A0A2X0SF61 ENST00000422918.5 ENST00000461052.5 H7C3G3 ENST00000370028.7 [P98171-2] ENST00000454164.5 ENST00000420383.5 E9PCM6 ENST00000422091.1 H7C3K8 ENST00000393721.5 F8WAR0 A0A8V8TPJ2 H7C2Z8 A0A0B4J1X7 C9JLA8

ARHGAP4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review