AP1S2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	37 studies	35% ± 11%	Explore
endothelial cell	32 studies	34% ± 14%	Explore
classical monocyte	27 studies	63% ± 16%	Explore
conventional dendritic cell	27 studies	59% ± 20%	Explore
non-classical monocyte	23 studies	62% ± 13%	Explore
monocyte	21 studies	50% ± 20%	Explore
plasmacytoid dendritic cell	19 studies	44% ± 14%	Explore
B cell	17 studies	24% ± 10%	Explore
dendritic cell	17 studies	52% ± 24%	Explore
myeloid cell	14 studies	36% ± 19%	Explore
capillary endothelial cell	13 studies	28% ± 11%	Explore
mast cell	12 studies	24% ± 5%	Explore
vein endothelial cell	12 studies	25% ± 8%	Explore
endothelial cell of vascular tree	11 studies	33% ± 8%	Explore
memory B cell	10 studies	21% ± 5%	Explore
platelet	9 studies	29% ± 9%	Explore
naive B cell	8 studies	18% ± 4%	Explore
endothelial cell of artery	8 studies	28% ± 10%	Explore
CD4-positive, alpha-beta T cell	7 studies	20% ± 4%	Explore
mononuclear phagocyte	6 studies	48% ± 18%	Explore
neutrophil	6 studies	46% ± 17%	Explore
leukocyte	6 studies	28% ± 6%	Explore
pericyte	6 studies	21% ± 4%	Explore
regulatory T cell	6 studies	21% ± 3%	Explore
glial cell	6 studies	54% ± 22%	Explore
fibroblast	6 studies	19% ± 1%	Explore
neuron	6 studies	46% ± 16%	Explore
retinal rod cell	6 studies	22% ± 7%	Explore
GABAergic neuron	6 studies	38% ± 12%	Explore
oligodendrocyte	6 studies	25% ± 7%	Explore
interneuron	6 studies	31% ± 14%	Explore
hematopoietic precursor cell	5 studies	32% ± 4%	Explore
natural killer cell	5 studies	23% ± 6%	Explore
smooth muscle cell	5 studies	38% ± 10%	Explore
cardiac muscle cell	5 studies	25% ± 3%	Explore
intermediate monocyte	5 studies	64% ± 18%	Explore
glutamatergic neuron	5 studies	30% ± 16%	Explore
hematopoietic stem cell	5 studies	24% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	17% ± 1%	Explore
glomerular endothelial cell	4 studies	56% ± 7%	Explore
retinal ganglion cell	4 studies	64% ± 28%	Explore
pro-B cell	4 studies	23% ± 1%	Explore
Schwann cell	4 studies	49% ± 20%	Explore
immature B cell	4 studies	22% ± 6%	Explore
precursor B cell	4 studies	29% ± 8%	Explore
retinal cone cell	4 studies	35% ± 18%	Explore
retinal pigment epithelial cell	4 studies	54% ± 24%	Explore
astrocyte	4 studies	25% ± 8%	Explore
monocyte-derived dendritic cell	3 studies	57% ± 31%	Explore
connective tissue cell	3 studies	29% ± 6%	Explore
myofibroblast cell	3 studies	42% ± 12%	Explore
megakaryocyte	3 studies	40% ± 16%	Explore
amacrine cell	3 studies	45% ± 15%	Explore
microglial cell	3 studies	25% ± 9%	Explore
rod bipolar cell	3 studies	20% ± 2%	Explore
endothelial cell of sinusoid	3 studies	23% ± 7%	Explore
granulocyte	3 studies	25% ± 10%	Explore
endothelial cell of lymphatic vessel	3 studies	21% ± 5%	Explore
CD8-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	18% ± 5%	Explore
melanocyte	3 studies	49% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	17% ± 1%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	21% ± 4%	Explore
T cell	3 studies	18% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	30% ± 8%	Explore
eye	8 studies	24% ± 9%	Explore
brain	7 studies	27% ± 7%	Explore
lung	6 studies	24% ± 5%	Explore
intestine	4 studies	24% ± 9%	Explore
kidney	4 studies	18% ± 3%	Explore
bone marrow	4 studies	21% ± 3%	Explore
heart	3 studies	16% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	2792.12	2630 / 2642	100%	48.33	705 / 705
breast	100%	1621.74	458 / 459	97%	19.14	1089 / 1118
thymus	100%	1504.82	650 / 653	97%	13.74	586 / 605
skin	87%	927.46	1579 / 1809	100%	173.56	471 / 472
uterus	99%	4251.28	169 / 170	86%	21.13	396 / 459
lung	99%	1779.58	573 / 578	86%	13.39	997 / 1155
prostate	98%	1351.81	241 / 245	86%	9.41	433 / 502
kidney	94%	1058.70	84 / 89	87%	16.75	783 / 901
esophagus	92%	3073.59	1336 / 1445	88%	12.03	161 / 183
ovary	83%	767.86	150 / 180	95%	18.98	407 / 430
adrenal gland	87%	786.07	224 / 258	88%	26.28	202 / 230
intestine	100%	3345.86	962 / 966	70%	9.20	368 / 527
bladder	100%	1665.86	21 / 21	62%	7.90	312 / 504
stomach	71%	1799.50	254 / 359	81%	11.38	232 / 286
pancreas	46%	315.60	150 / 328	84%	11.65	150 / 178
eye	0%	0	0 / 0	100%	132.55	80 / 80
lymph node	0%	0	0 / 0	100%	34.16	29 / 29
muscle	100%	4061.34	803 / 803	0%	0	0 / 0
spleen	100%	2719.69	241 / 241	0%	0	0 / 0
adipose	100%	2069.55	1202 / 1204	0%	0	0 / 0
blood vessel	100%	2142.78	1329 / 1335	0%	0	0 / 0
heart	98%	3327.34	845 / 861	0%	0	0 / 0
peripheral blood	88%	2101.28	814 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	78%	8.27	35 / 45
liver	16%	112.14	37 / 226	26%	2.89	105 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1903232	Biological process	melanosome assembly
GO_0016192	Biological process	vesicle-mediated transport
GO_0006886	Biological process	intracellular protein transport
GO_0060155	Biological process	platelet dense granule organization
GO_0032588	Cellular component	trans-Golgi network membrane
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005905	Cellular component	clathrin-coated pit
GO_0030119	Cellular component	AP-type membrane coat adaptor complex
GO_0000139	Cellular component	Golgi membrane
GO_0030121	Cellular component	AP-1 adaptor complex
GO_0005829	Cellular component	cytosol
GO_0005794	Cellular component	Golgi apparatus
GO_0030659	Cellular component	cytoplasmic vesicle membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0005769	Cellular component	early endosome
GO_0005515	Molecular function	protein binding
GO_0035615	Molecular function	clathrin adaptor activity

IV. Literature review

[source]

Gene name	AP1S2
Protein name	AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin) AP complex subunit sigma
Synonyms	hCG_1982256 DC22
Description	FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Accessions	ENST00000329235.6 [P56377-1] A0A5F9ZHW1 H7BZG6 ENST00000479184.2 ENST00000450644.2 A6NH01 ENST00000671830.1 ENST00000673445.1 A0A5F9ZHX2 P56377 F6SFB5 ENST00000673591.1 ENST00000380291.5 ENST00000452376.5 ENST00000672987.1 A0A5F9ZI43 H0Y673 ENST00000545766.7 ENST00000672063.1 Q549M9

AP1S2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review