AK2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	16 studies	26% ± 9%	Explore
basal cell	12 studies	28% ± 13%	Explore
epithelial cell	11 studies	37% ± 18%	Explore
B cell	10 studies	19% ± 6%	Explore
conventional dendritic cell	10 studies	30% ± 16%	Explore
macrophage	9 studies	21% ± 8%	Explore
endothelial cell of lymphatic vessel	9 studies	24% ± 9%	Explore
natural killer cell	8 studies	24% ± 7%	Explore
abnormal cell	8 studies	25% ± 10%	Explore
fibroblast	8 studies	27% ± 9%	Explore
ciliated cell	8 studies	29% ± 11%	Explore
CD8-positive, alpha-beta T cell	8 studies	23% ± 7%	Explore
endothelial cell of vascular tree	8 studies	22% ± 4%	Explore
secretory cell	7 studies	24% ± 10%	Explore
epithelial cell of proximal tubule	7 studies	32% ± 9%	Explore
progenitor cell	7 studies	22% ± 5%	Explore
monocyte	7 studies	22% ± 9%	Explore
plasmacytoid dendritic cell	7 studies	26% ± 8%	Explore
hematopoietic precursor cell	6 studies	33% ± 11%	Explore
classical monocyte	6 studies	24% ± 8%	Explore
kidney loop of Henle epithelial cell	6 studies	24% ± 6%	Explore
connective tissue cell	6 studies	21% ± 5%	Explore
endothelial cell of artery	6 studies	18% ± 3%	Explore
enterocyte	6 studies	27% ± 4%	Explore
retinal cone cell	6 studies	38% ± 14%	Explore
pericyte	6 studies	18% ± 3%	Explore
CD4-positive, alpha-beta T cell	6 studies	28% ± 10%	Explore
regulatory T cell	6 studies	22% ± 8%	Explore
club cell	5 studies	28% ± 10%	Explore
smooth muscle cell	5 studies	19% ± 2%	Explore
erythroblast	5 studies	40% ± 11%	Explore
naive B cell	5 studies	19% ± 5%	Explore
vein endothelial cell	5 studies	22% ± 2%	Explore
oligodendrocyte precursor cell	5 studies	22% ± 5%	Explore
dendritic cell	5 studies	32% ± 14%	Explore
transit amplifying cell	5 studies	23% ± 6%	Explore
respiratory goblet cell	4 studies	31% ± 19%	Explore
non-classical monocyte	4 studies	23% ± 6%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	33% ± 8%	Explore
T cell	4 studies	21% ± 7%	Explore
hematopoietic stem cell	4 studies	26% ± 2%	Explore
myofibroblast cell	4 studies	19% ± 1%	Explore
myeloid cell	4 studies	30% ± 10%	Explore
capillary endothelial cell	4 studies	21% ± 2%	Explore
precursor B cell	4 studies	28% ± 8%	Explore
pro-B cell	4 studies	26% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	26% ± 8%	Explore
astrocyte	4 studies	23% ± 6%	Explore
enteroendocrine cell	4 studies	24% ± 6%	Explore
goblet cell	4 studies	25% ± 8%	Explore
oligodendrocyte	4 studies	21% ± 1%	Explore
gamma-delta T cell	4 studies	27% ± 17%	Explore
memory B cell	4 studies	23% ± 8%	Explore
plasmablast	3 studies	51% ± 10%	Explore
pancreatic A cell	3 studies	53% ± 7%	Explore
type B pancreatic cell	3 studies	46% ± 6%	Explore
renal alpha-intercalated cell	3 studies	31% ± 10%	Explore
common myeloid progenitor	3 studies	35% ± 8%	Explore
lymphocyte	3 studies	24% ± 5%	Explore
plasma cell	3 studies	36% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	22% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	20% ± 1%	Explore
type I pneumocyte	3 studies	27% ± 11%	Explore
type II pneumocyte	3 studies	35% ± 17%	Explore
germinal center B cell	3 studies	22% ± 5%	Explore
GABAergic neuron	3 studies	30% ± 5%	Explore
glutamatergic neuron	3 studies	33% ± 10%	Explore
granulocyte monocyte progenitor cell	3 studies	34% ± 11%	Explore
mucosal invariant T cell	3 studies	15% ± 0%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	18% ± 3%	Explore
hepatocyte	3 studies	40% ± 17%	Explore
microglial cell	3 studies	20% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
kidney	9 studies	21% ± 5%	Explore
lung	9 studies	23% ± 8%	Explore
peripheral blood	7 studies	19% ± 5%	Explore
intestine	7 studies	20% ± 6%	Explore
brain	6 studies	26% ± 6%	Explore
eye	4 studies	20% ± 3%	Explore
liver	4 studies	29% ± 11%	Explore
pancreas	3 studies	47% ± 6%	Explore
bone marrow	3 studies	22% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	6371.58	459 / 459	100%	49.99	1118 / 1118
esophagus	100%	5077.94	1445 / 1445	100%	34.07	183 / 183
intestine	100%	5888.07	966 / 966	100%	45.08	527 / 527
liver	100%	6408.25	226 / 226	100%	32.53	406 / 406
lung	100%	5116.00	578 / 578	100%	47.57	1155 / 1155
ovary	100%	4597.12	180 / 180	100%	53.04	430 / 430
pancreas	100%	2939.57	328 / 328	100%	33.52	178 / 178
prostate	100%	5116.37	245 / 245	100%	38.07	502 / 502
skin	100%	6197.48	1809 / 1809	100%	64.56	472 / 472
stomach	100%	4413.78	359 / 359	100%	39.38	286 / 286
uterus	100%	5116.60	170 / 170	100%	55.98	459 / 459
kidney	100%	9434.42	89 / 89	100%	42.76	900 / 901
thymus	100%	7365.95	653 / 653	100%	46.04	604 / 605
bladder	100%	4909.48	21 / 21	100%	45.75	503 / 504
brain	100%	2783.22	2630 / 2642	100%	30.54	704 / 705
adrenal gland	100%	5684.95	258 / 258	95%	18.81	219 / 230
adipose	100%	6044.73	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	49.96	29 / 29
muscle	100%	5123.97	803 / 803	0%	0	0 / 0
spleen	100%	4977.89	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	59.15	45 / 45
ureter	0%	0	0 / 0	100%	16.78	1 / 1
blood vessel	100%	4088.96	1333 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	30.44	79 / 80
heart	99%	3986.23	850 / 861	0%	0	0 / 0
peripheral blood	98%	6027.84	909 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0046940	Biological process	nucleoside monophosphate phosphorylation
GO_0046033	Biological process	AMP metabolic process
GO_0006172	Biological process	ADP biosynthetic process
GO_0046034	Biological process	ATP metabolic process
GO_0015949	Biological process	nucleobase-containing small molecule interconversion
GO_0005758	Cellular component	mitochondrial intermembrane space
GO_0070062	Cellular component	extracellular exosome
GO_0097226	Cellular component	sperm mitochondrial sheath
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0004017	Molecular function	adenylate kinase activity
GO_0005515	Molecular function	protein binding
GO_0005524	Molecular function	ATP binding

IV. Literature review

[source]

Gene name	AK2
Protein name	nucleoside-diphosphate kinase (EC 2.7.4.6) Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed] Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) Adenylate kinase 2
Synonyms	ADK2 hCG_2032090
Description	FUNCTION: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. . FUNCTION: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. . FUNCTION: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. .
Accessions	ENST00000487289.1 ENST00000480134.5 ENST00000491241.2 F8VY04 P54819 F8VZG5 ENST00000695604.1 ENST00000354858.11 ENST00000695601.1 G3V213 ENST00000695605.1 ENST00000550338.6 ENST00000673291.1 A0A140VK93 ENST00000695602.1 ENST00000467905.5 A0A5F9ZHP2 ENST00000695599.1 A0A8Q3SHW4 ENST00000672715.1 [P54819-1] F8W1A4 ENST00000373449.7 [P54819-2] F8VPP1 ENST00000548033.5 A0A5K1VW67

AK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review