AGO3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035196Biological processmiRNA processing
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0006402Biological processmRNA catabolic process
GO_0090625Biological processsiRNA-mediated gene silencing by mRNA destabilization
GO_0035279Biological processmiRNA-mediated gene silencing by mRNA destabilization
GO_0035278Biological processmiRNA-mediated gene silencing by inhibition of translation
GO_0010628Biological processpositive regulation of gene expression
GO_0031054Biological processpre-miRNA processing
GO_0072091Biological processregulation of stem cell proliferation
GO_0035194Biological processregulatory ncRNA-mediated post-transcriptional gene silencing
GO_0070922Biological processRISC complex assembly
GO_0010501Biological processRNA secondary structure unwinding
GO_0070578Cellular componentRISC-loading complex
GO_0016020Cellular componentmembrane
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0005654Cellular componentnucleoplasm
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0016442Cellular componentRISC complex
GO_0005634Cellular componentnucleus
GO_0004521Molecular functionRNA endonuclease activity
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0090624Molecular functionendoribonuclease activity, cleaving miRNA-paired mRNA
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameAGO3
Protein nameProtein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)
Protein argonaute-3 (Argonaute3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)
Argonaute RISC catalytic component 3 (Eukaryotic translation initiation factor 2C, 3, isoform CRA_a)
Argonaute RISC catalytic component 3
SynonymshCG_1640521
EIF2C3
DescriptionFUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity . .

FUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. .

AccessionsENST00000246314.10 [Q9H9G7-2]
ENST00000634486.1
Q9H9G7
ENST00000373191.9 [Q9H9G7-1]
ENST00000397828.3
A0A0U1RR19
ENST00000324350.9
A8KA05
Q5TA56