AGO2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035196Biological processmiRNA processing
GO_0009791Biological processpost-embryonic development
GO_0090625Biological processsiRNA-mediated gene silencing by mRNA destabilization
GO_0035279Biological processmiRNA-mediated gene silencing by mRNA destabilization
GO_0035278Biological processmiRNA-mediated gene silencing by inhibition of translation
GO_0045766Biological processpositive regulation of angiogenesis
GO_1901165Biological processpositive regulation of trophoblast cell migration
GO_0060213Biological processpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO_0006412Biological processtranslation
GO_0090128Biological processregulation of synapse maturation
GO_0033962Biological processP-body assembly
GO_0006413Biological processtranslational initiation
GO_0031054Biological processpre-miRNA processing
GO_1900153Biological processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0035194Biological processregulatory ncRNA-mediated post-transcriptional gene silencing
GO_0031047Biological processregulatory ncRNA-mediated gene silencing
GO_0045947Biological processnegative regulation of translational initiation
GO_0042985Biological processnegative regulation of amyloid precursor protein biosynthetic process
GO_0045727Biological processpositive regulation of translation
GO_0030422Biological processsiRNA processing
GO_0070922Biological processRISC complex assembly
GO_0010501Biological processRNA secondary structure unwinding
GO_0010586Biological processmiRNA metabolic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0098978Cellular componentglutamatergic synapse
GO_0070578Cellular componentRISC-loading complex
GO_0016020Cellular componentmembrane
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0098794Cellular componentpostsynapse
GO_0030425Cellular componentdendrite
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0016442Cellular componentRISC complex
GO_0005634Cellular componentnucleus
GO_0070551Molecular functionendoribonuclease activity, cleaving siRNA-paired mRNA
GO_0004521Molecular functionRNA endonuclease activity
GO_0000340Molecular functionRNA 7-methylguanosine cap binding
GO_0001046Molecular functioncore promoter sequence-specific DNA binding
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0098808Molecular functionmRNA cap binding
GO_0035197Molecular functionsiRNA binding
GO_0003743Molecular functiontranslation initiation factor activity
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0003725Molecular functiondouble-stranded RNA binding
GO_0090624Molecular functionendoribonuclease activity, cleaving miRNA-paired mRNA
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAGO2
Protein nameProtein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Argonaute RISC catalytic component 2
SynonymsEIF2C2
DescriptionFUNCTION: Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. .; FUNCTION: (Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response. .

AccessionsQ9UKV8
E5RGG9
E5RJY2
ENST00000220592.10 [Q9UKV8-1]
ENST00000523609.5
ENST00000519980.5 [Q9UKV8-2]
ENST00000524328.1