ADRB2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ADRB2 at tissue level.

III. Associated gene sets

GO_0006939Biological processsmooth muscle contraction
GO_0006366Biological processtranscription by RNA polymerase II
GO_0050873Biological processbrown fat cell differentiation
GO_0045986Biological processnegative regulation of smooth muscle contraction
GO_0007188Biological processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0071880Biological processadenylate cyclase-activating adrenergic receptor signaling pathway
GO_0002028Biological processregulation of sodium ion transport
GO_0007171Biological processactivation of transmembrane receptor protein tyrosine kinase activity
GO_0006898Biological processreceptor-mediated endocytosis
GO_0002024Biological processdiet induced thermogenesis
GO_1990911Biological processresponse to psychosocial stress
GO_2000969Biological processpositive regulation of AMPA receptor activity
GO_1904504Biological processpositive regulation of lipophagy
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0040015Biological processnegative regulation of multicellular organism growth
GO_0002025Biological processnorepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
GO_0045744Biological processnegative regulation of G protein-coupled receptor signaling pathway
GO_0061885Biological processpositive regulation of mini excitatory postsynaptic potential
GO_0010739Biological processpositive regulation of protein kinase A signaling
GO_0008333Biological processendosome to lysosome transport
GO_0009409Biological processresponse to cold
GO_0031649Biological processheat generation
GO_0045453Biological processbone resorption
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_2000481Biological processpositive regulation of cAMP-dependent protein kinase activity
GO_1901098Biological processpositive regulation of autophagosome maturation
GO_0071875Biological processadrenergic receptor signaling pathway
GO_0030501Biological processpositive regulation of bone mineralization
GO_0071902Biological processpositive regulation of protein serine/threonine kinase activity
GO_1904646Biological processcellular response to amyloid-beta
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0007166Biological processcell surface receptor signaling pathway
GO_0016324Cellular componentapical plasma membrane
GO_0098992Cellular componentneuronal dense core vesicle
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0005764Cellular componentlysosome
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0005794Cellular componentGolgi apparatus
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0001540Molecular functionamyloid-beta binding
GO_0042802Molecular functionidentical protein binding
GO_0051380Molecular functionnorepinephrine binding
GO_0015459Molecular functionpotassium channel regulator activity
GO_0008179Molecular functionadenylate cyclase binding
GO_0005515Molecular functionprotein binding
GO_0004941Molecular functionbeta2-adrenergic receptor activity

IV. Literature review

[source]
Gene nameADRB2
Protein nameBeta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2 adrenoreceptor)
Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
ADRB2 protein
SynonymsB2AR
ADRB2R
DescriptionFUNCTION: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. .

FUNCTION: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. .

FUNCTION: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. .

AccessionsA2N4T7
Q9BYZ0
X5DQM5
P07550
ENST00000305988.6