VPS13B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016192Biological processvesicle-mediated transport
GO_0007030Biological processGolgi organization
GO_0032458Biological processslow endocytic recycling
GO_0036438Biological processmaintenance of lens transparency
GO_0001675Biological processacrosome assembly
GO_0060612Biological processadipose tissue development
GO_0007399Biological processnervous system development
GO_0006869Biological processlipid transport
GO_0007417Biological processcentral nervous system development
GO_0031175Biological processneuron projection development
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0002080Cellular componentacrosomal membrane
GO_0000139Cellular componentGolgi membrane
GO_0031901Cellular componentearly endosome membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding

IV. Literature review

[source]
Gene nameVPS13B
Protein nameVacuolar protein sorting 13 homolog B
Alternative protein VPS13B
VPS13B protein
Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B)
SynonymsCHS1
KIAA0532
COH1
DescriptionFUNCTION: Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes . Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane . Plays a role in the development of the nervous system, and may be required for neuron projection development . May also play a role during adipose tissue development . Required for maintenance of the ocular lens (By similarity). .

AccessionsA0A8C8KE22
A0A804HKG9
A0A804HJ62
Q8N509
ENST00000682153.1
ENST00000441350.2 [Q7Z7G8-5]
ENST00000358544.7 [Q7Z7G8-1]
ENST00000357162.7 [Q7Z7G8-2]
Q8WW67
H0YB72
ENST00000496144.5 [Q7Z7G8-3]
Q7Z7G8
A0A804HL73
ENST00000521559.1
ENST00000683334.1
ENST00000355155.6
L8EAQ4
ENST00000682234.1