USP10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0071347Biological processcellular response to interleukin-1
GO_0035520Biological processmonoubiquitinated protein deubiquitination
GO_0072344Biological processrescue of stalled ribosome
GO_0010506Biological processregulation of autophagy
GO_0006508Biological processproteolysis
GO_0016579Biological processprotein deubiquitination
GO_0006914Biological processautophagy
GO_0019985Biological processtranslesion synthesis
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0030330Biological processDNA damage response, signal transduction by p53 class mediator
GO_0062030Biological processnegative regulation of stress granule assembly
GO_0022626Cellular componentcytosolic ribosome
GO_0005769Cellular componentearly endosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0002039Molecular functionp53 binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0003723Molecular functionRNA binding
GO_0140678Molecular functionmolecular function inhibitor activity
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUSP10
Protein nameUbiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)
Ubiquitin specific peptidase 10
ubiquitinyl hydrolase 1 (EC 3.4.19.12)
SynonymsDKFZp686E14181
KIAA0190
DescriptionFUNCTION: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR . Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 . Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response . Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes . In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 . Does not deubiquitinate MDM2 . Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits . Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules . Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome . Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling . Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling . Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage . Deubiquitinates TBX21 leading to its stabilization . Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation . .

AccessionsH3BVF1
H3BNA1
ENST00000563048.5
ENST00000567526.1
H3BNS8
ENST00000219473.12 [Q14694-1]
H3BQP1
ENST00000569925.1
ENST00000540269.6
ENST00000563386.5
ENST00000570053.1
J3KT19
H3BNP1
Q6P2I0
ENST00000569038.5
Q68D90
H3BNL0
ENST00000563892.5
H3BQC6
ENST00000562283.5
ENST00000570191.5 [Q14694-3]
Q14694