URM1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	11 studies	23% ± 4%	Explore
natural killer cell	11 studies	21% ± 5%	Explore
regulatory T cell	11 studies	20% ± 3%	Explore
B cell	9 studies	19% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	19% ± 2%	Explore
endothelial cell	9 studies	24% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	20% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	19% ± 4%	Explore
CD4-positive, alpha-beta T cell	7 studies	21% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	19% ± 3%	Explore
classical monocyte	5 studies	22% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	18% ± 2%	Explore
mature NK T cell	5 studies	18% ± 2%	Explore
fibroblast	5 studies	23% ± 9%	Explore
epithelial cell	5 studies	34% ± 16%	Explore
oligodendrocyte	5 studies	24% ± 4%	Explore
hematopoietic precursor cell	4 studies	28% ± 9%	Explore
exhausted T cell	4 studies	26% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	17% ± 1%	Explore
non-classical monocyte	4 studies	28% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	23% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
gamma-delta T cell	4 studies	26% ± 15%	Explore
T cell	4 studies	18% ± 2%	Explore
conventional dendritic cell	3 studies	37% ± 10%	Explore
ciliated cell	3 studies	26% ± 2%	Explore
T follicular helper cell	3 studies	18% ± 3%	Explore
abnormal cell	3 studies	28% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	22% ± 2%	Explore
endothelial cell of vascular tree	3 studies	19% ± 2%	Explore
dendritic cell	3 studies	38% ± 10%	Explore
intestinal crypt stem cell	3 studies	17% ± 1%	Explore
basal cell	3 studies	31% ± 11%	Explore
goblet cell	3 studies	20% ± 6%	Explore
hematopoietic stem cell	3 studies	20% ± 2%	Explore
plasmacytoid dendritic cell	3 studies	22% ± 2%	Explore
memory B cell	3 studies	17% ± 2%	Explore
mucosal invariant T cell	3 studies	17% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	20% ± 5%	Explore
lung	4 studies	24% ± 5%	Explore
brain	4 studies	23% ± 6%	Explore
intestine	3 studies	22% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3079.92	1445 / 1445	100%	42.77	183 / 183
liver	100%	2020.44	226 / 226	100%	37.84	406 / 406
ovary	100%	2810.58	180 / 180	100%	50.32	430 / 430
pancreas	100%	2591.39	328 / 328	100%	49.80	178 / 178
skin	100%	3413.81	1809 / 1809	100%	82.64	472 / 472
stomach	100%	2789.70	359 / 359	100%	55.10	286 / 286
thymus	100%	3196.17	653 / 653	100%	50.76	605 / 605
uterus	100%	3340.61	170 / 170	100%	51.37	459 / 459
brain	100%	2696.05	2640 / 2642	100%	67.58	705 / 705
lung	100%	2898.93	578 / 578	100%	41.08	1154 / 1155
kidney	100%	3103.35	89 / 89	100%	43.56	900 / 901
intestine	100%	3267.39	966 / 966	100%	60.34	525 / 527
adrenal gland	100%	3524.54	258 / 258	100%	44.86	229 / 230
prostate	100%	3595.33	245 / 245	99%	47.96	499 / 502
breast	100%	3307.56	459 / 459	99%	46.90	1110 / 1118
bladder	100%	3402.48	21 / 21	99%	52.34	500 / 504
adipose	100%	3229.59	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	106.16	80 / 80
lymph node	0%	0	0 / 0	100%	78.79	29 / 29
spleen	100%	4202.63	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	51.19	45 / 45
ureter	0%	0	0 / 0	100%	41.89	1 / 1
blood vessel	100%	2823.95	1334 / 1335	0%	0	0 / 0
heart	100%	2665.56	860 / 861	0%	0	0 / 0
muscle	100%	2248.79	802 / 803	0%	0	0 / 0
peripheral blood	97%	2156.68	902 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002098	Biological process	tRNA wobble uridine modification
GO_0034227	Biological process	tRNA thio-modification
GO_0032447	Biological process	protein urmylation
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0097163	Molecular function	sulfur carrier activity
GO_0031386	Molecular function	protein tag activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	URM1
Protein name	Ubiquitin-related modifier 1 Ubiquitin related modifier 1
Synonyms	C9orf74
Description	FUNCTION: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. .
Accessions	ENST00000372850.5 [Q9BTM9-3] ENST00000470840.5 Q9BTM9 ENST00000372847.1 ENST00000483206.2 [Q9BTM9-2] Q5T4A9 ENST00000372853.9 [Q9BTM9-1]

URM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review