UBTF | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	14 studies	21% ± 8%	Explore
natural killer cell	14 studies	25% ± 16%	Explore
CD8-positive, alpha-beta T cell	12 studies	23% ± 7%	Explore
endothelial cell	8 studies	27% ± 8%	Explore
memory B cell	8 studies	18% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	22% ± 7%	Explore
plasmacytoid dendritic cell	7 studies	20% ± 4%	Explore
smooth muscle cell	6 studies	31% ± 31%	Explore
naive B cell	6 studies	20% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	20% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	29% ± 17%	Explore
gamma-delta T cell	6 studies	26% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	20% ± 3%	Explore
CD4-positive, alpha-beta T cell	5 studies	22% ± 4%	Explore
pericyte	5 studies	32% ± 26%	Explore
epithelial cell	5 studies	34% ± 15%	Explore
fibroblast	5 studies	35% ± 22%	Explore
innate lymphoid cell	5 studies	29% ± 24%	Explore
regulatory T cell	5 studies	31% ± 24%	Explore
T cell	4 studies	26% ± 6%	Explore
endothelial cell of lymphatic vessel	4 studies	36% ± 29%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	21% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	21% ± 7%	Explore
neuron	4 studies	25% ± 11%	Explore
ciliated cell	4 studies	26% ± 9%	Explore
basal cell	4 studies	38% ± 19%	Explore
leukocyte	3 studies	19% ± 2%	Explore
conventional dendritic cell	3 studies	45% ± 28%	Explore
mature NK T cell	3 studies	18% ± 2%	Explore
abnormal cell	3 studies	18% ± 0%	Explore
retinal bipolar neuron	3 studies	21% ± 3%	Explore
immature B cell	3 studies	22% ± 6%	Explore
precursor B cell	3 studies	21% ± 2%	Explore
pro-B cell	3 studies	20% ± 1%	Explore
dendritic cell	3 studies	55% ± 23%	Explore
enteroendocrine cell	3 studies	21% ± 7%	Explore
mucosal invariant T cell	3 studies	18% ± 3%	Explore
erythroblast	3 studies	28% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	4 studies	23% ± 7%	Explore
lung	4 studies	19% ± 3%	Explore
brain	3 studies	23% ± 4%	Explore
intestine	3 studies	21% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6864.23	1445 / 1445	100%	48.66	183 / 183
ovary	100%	6572.75	180 / 180	100%	51.62	430 / 430
prostate	100%	7845.19	245 / 245	100%	82.41	502 / 502
skin	100%	8325.96	1809 / 1809	100%	76.95	472 / 472
stomach	100%	5022.94	359 / 359	100%	51.88	286 / 286
thymus	100%	9158.33	653 / 653	100%	95.82	605 / 605
uterus	100%	8247.19	170 / 170	100%	80.26	459 / 459
lung	100%	5320.07	578 / 578	100%	57.53	1154 / 1155
breast	100%	6258.55	459 / 459	100%	81.29	1117 / 1118
brain	100%	5793.45	2639 / 2642	100%	80.32	705 / 705
kidney	100%	5759.76	89 / 89	100%	52.20	899 / 901
pancreas	100%	4130.47	327 / 328	100%	57.70	178 / 178
intestine	100%	7446.08	966 / 966	100%	54.75	525 / 527
bladder	100%	7653.05	21 / 21	100%	63.30	502 / 504
liver	100%	3707.00	226 / 226	100%	40.80	404 / 406
adrenal gland	100%	6247.02	258 / 258	99%	50.80	227 / 230
adipose	100%	5785.19	1204 / 1204	0%	0	0 / 0
blood vessel	100%	6470.56	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	64.34	80 / 80
lymph node	0%	0	0 / 0	100%	105.01	29 / 29
spleen	100%	9021.22	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	73.70	45 / 45
ureter	0%	0	0 / 0	100%	30.66	1 / 1
heart	100%	4128.34	857 / 861	0%	0	0 / 0
muscle	100%	5054.92	799 / 803	0%	0	0 / 0
peripheral blood	96%	4614.18	892 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001188	Biological process	RNA polymerase I preinitiation complex assembly
GO_0006361	Biological process	transcription initiation at RNA polymerase I promoter
GO_1902659	Biological process	regulation of glucose mediated signaling pathway
GO_0045943	Biological process	positive regulation of transcription by RNA polymerase I
GO_0006360	Biological process	transcription by RNA polymerase I
GO_0005730	Cellular component	nucleolus
GO_0001650	Cellular component	fibrillar center
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0001181	Molecular function	RNA polymerase I general transcription initiation factor activity
GO_0097110	Molecular function	scaffold protein binding
GO_0005515	Molecular function	protein binding
GO_0001165	Molecular function	RNA polymerase I cis-regulatory region sequence-specific DNA binding
GO_0003682	Molecular function	chromatin binding
GO_0001164	Molecular function	RNA polymerase I core promoter sequence-specific DNA binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	UBTF
Protein name	Upstream binding transcription factor, RNA polymerase I UBTF protein Ribosomal RNA upstream binding transcription factor Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) Upstream binding transcription factor Upstream binding transcription factor, RNA polymerase I, isoform CRA_a (cDNA FLJ53802, highly similar to Nucleolar transcription factor 1)
Synonyms	UBF1 UBF hCG_30294
Description	FUNCTION: Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. .
Accessions	P17480 Q05BZ1 ENST00000704746.1 [P17480-1] E9PKP7 ENST00000704742.1 [P17480-2] ENST00000533177.5 [P17480-2] ENST00000302904.8 [P17480-1] ENST00000393606.7 [P17480-2] Q9BQR2 E9PMM2 A0A994J4N4 ENST00000530828.1 ENST00000704740.1 ENST00000529373.1 ENST00000704741.1 [P17480-1] ENST00000529383.5 [P17480-1] B4DLB0 O00164 ENST00000436088.6 [P17480-1] E9PLT2 ENST00000526094.5 [P17480-2] ENST00000527034.5 ENST00000343638.9 [P17480-2]

UBTF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review