Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 29 studies | 31% ± 13% | |
| pericyte | 23 studies | 26% ± 10% | |
| macrophage | 22 studies | 29% ± 14% | |
| fibroblast | 21 studies | 26% ± 9% | |
| B cell | 15 studies | 23% ± 8% | |
| smooth muscle cell | 15 studies | 22% ± 6% | |
| astrocyte | 14 studies | 33% ± 13% | |
| endothelial cell of lymphatic vessel | 12 studies | 32% ± 11% | |
| microglial cell | 11 studies | 43% ± 13% | |
| oligodendrocyte precursor cell | 11 studies | 32% ± 12% | |
| epithelial cell | 10 studies | 36% ± 19% | |
| oligodendrocyte | 10 studies | 28% ± 8% | |
| ciliated cell | 9 studies | 27% ± 11% | |
| classical monocyte | 8 studies | 23% ± 8% | |
| GABAergic neuron | 8 studies | 33% ± 16% | |
| connective tissue cell | 8 studies | 22% ± 6% | |
| vein endothelial cell | 8 studies | 26% ± 13% | |
| type I pneumocyte | 8 studies | 30% ± 9% | |
| adipocyte | 8 studies | 25% ± 7% | |
| myeloid cell | 7 studies | 32% ± 8% | |
| type II pneumocyte | 7 studies | 31% ± 9% | |
| monocyte | 7 studies | 29% ± 7% | |
| dendritic cell | 7 studies | 31% ± 15% | |
| non-classical monocyte | 6 studies | 25% ± 7% | |
| conventional dendritic cell | 6 studies | 30% ± 12% | |
| myofibroblast cell | 6 studies | 27% ± 8% | |
| interneuron | 6 studies | 36% ± 17% | |
| neuron | 6 studies | 37% ± 16% | |
| plasma cell | 6 studies | 22% ± 8% | |
| capillary endothelial cell | 6 studies | 26% ± 8% | |
| Mueller cell | 6 studies | 21% ± 4% | |
| endothelial cell of vascular tree | 6 studies | 24% ± 12% | |
| basal cell | 6 studies | 40% ± 21% | |
| club cell | 6 studies | 26% ± 10% | |
| naive B cell | 6 studies | 20% ± 5% | |
| plasmacytoid dendritic cell | 6 studies | 22% ± 7% | |
| memory B cell | 5 studies | 17% ± 1% | |
| precursor B cell | 5 studies | 31% ± 11% | |
| mononuclear phagocyte | 5 studies | 28% ± 9% | |
| hematopoietic precursor cell | 4 studies | 39% ± 12% | |
| progenitor cell | 4 studies | 25% ± 4% | |
| T cell | 4 studies | 24% ± 5% | |
| endothelial cell of artery | 4 studies | 20% ± 3% | |
| granule cell | 4 studies | 18% ± 3% | |
| retinal ganglion cell | 4 studies | 41% ± 23% | |
| pro-B cell | 4 studies | 29% ± 5% | |
| retina horizontal cell | 4 studies | 23% ± 8% | |
| retinal pigment epithelial cell | 4 studies | 29% ± 15% | |
| cardiac muscle cell | 4 studies | 22% ± 4% | |
| mesothelial cell | 4 studies | 31% ± 12% | |
| lymphocyte | 4 studies | 25% ± 9% | |
| glutamatergic neuron | 4 studies | 52% ± 11% | |
| hematopoietic stem cell | 4 studies | 26% ± 12% | |
| natural killer cell | 4 studies | 18% ± 3% | |
| goblet cell | 4 studies | 35% ± 21% | |
| kidney distal convoluted tubule epithelial cell | 3 studies | 19% ± 3% | |
| immature B cell | 3 studies | 21% ± 4% | |
| amacrine cell | 3 studies | 29% ± 9% | |
| retinal bipolar neuron | 3 studies | 30% ± 6% | |
| GABAergic amacrine cell | 3 studies | 18% ± 2% | |
| glycinergic amacrine cell | 3 studies | 19% ± 2% | |
| rod bipolar cell | 3 studies | 30% ± 9% | |
| germinal center B cell | 3 studies | 23% ± 0% | |
| hepatocyte | 3 studies | 32% ± 21% | |
| muscle cell | 3 studies | 38% ± 22% | |
| neural progenitor cell | 3 studies | 29% ± 7% | |
| ependymal cell | 3 studies | 30% ± 12% | |
| mast cell | 3 studies | 32% ± 6% | |
| megakaryocyte-erythroid progenitor cell | 3 studies | 41% ± 17% | |
| intestinal crypt stem cell | 3 studies | 19% ± 2% | |
| leukocyte | 3 studies | 31% ± 10% | |
| alveolar macrophage | 3 studies | 31% ± 8% | |
| chondrocyte | 3 studies | 27% ± 3% | |
| respiratory goblet cell | 3 studies | 34% ± 15% | |
| transit amplifying cell | 3 studies | 36% ± 27% | |
| mucus secreting cell | 3 studies | 25% ± 6% | |
| enteroendocrine cell | 3 studies | 26% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 3065.03 | 180 / 180 | 100% | 34.09 | 429 / 430 |
| brain | 100% | 3311.43 | 2641 / 2642 | 100% | 43.71 | 702 / 705 |
| lung | 100% | 3661.03 | 578 / 578 | 99% | 19.97 | 1149 / 1155 |
| intestine | 100% | 3388.27 | 966 / 966 | 99% | 20.16 | 523 / 527 |
| stomach | 100% | 2411.07 | 359 / 359 | 99% | 18.96 | 283 / 286 |
| esophagus | 100% | 3798.26 | 1445 / 1445 | 99% | 12.33 | 181 / 183 |
| breast | 100% | 3298.12 | 459 / 459 | 98% | 23.65 | 1095 / 1118 |
| skin | 100% | 3674.81 | 1809 / 1809 | 98% | 24.10 | 462 / 472 |
| bladder | 100% | 3587.33 | 21 / 21 | 97% | 20.68 | 487 / 504 |
| prostate | 100% | 3367.78 | 245 / 245 | 97% | 21.92 | 485 / 502 |
| pancreas | 98% | 1263.27 | 322 / 328 | 97% | 15.27 | 173 / 178 |
| thymus | 100% | 3005.18 | 653 / 653 | 95% | 17.57 | 574 / 605 |
| uterus | 100% | 3225.58 | 170 / 170 | 93% | 17.70 | 426 / 459 |
| kidney | 100% | 2667.99 | 89 / 89 | 92% | 13.64 | 827 / 901 |
| adrenal gland | 100% | 2268.93 | 258 / 258 | 84% | 9.71 | 193 / 230 |
| liver | 100% | 1207.92 | 225 / 226 | 77% | 7.36 | 311 / 406 |
| adipose | 100% | 3355.62 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3060.49 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 2835.67 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 3031.45 | 241 / 241 | 0% | 0 | 0 / 0 |
| heart | 99% | 1951.59 | 850 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 15.75 | 43 / 45 |
| eye | 0% | 0 | 0 / 0 | 93% | 12.37 | 74 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 19.78 | 26 / 29 |
| peripheral blood | 82% | 2722.20 | 758 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
| GO_0032020 | Biological process | ISG15-protein conjugation |
| GO_0070936 | Biological process | protein K48-linked ubiquitination |
| GO_0000209 | Biological process | protein polyubiquitination |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0000151 | Cellular component | ubiquitin ligase complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005634 | Cellular component | nucleus |
| GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
| GO_0061631 | Molecular function | ubiquitin conjugating enzyme activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0042296 | Molecular function | ISG15 transferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | UBE2E1 |
| Protein name | Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1) E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) |
| Synonyms | UBCH6 |
| Description | FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. . |
| Accessions | ENST00000424381.5 [P51965-2] C9J2P0 ENST00000346855.7 [P51965-3] B7Z306 H7C061 P51965 ENST00000306627.8 [P51965-1] ENST00000467766.5 ENST00000452012.1 ENST00000442670.5 |