TRPC4AP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0140627Biological processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO_0048820Biological processhair follicle maturation
GO_0070588Biological processcalcium ion transmembrane transport
GO_0080008Cellular componentCul4-RING E3 ubiquitin ligase complex
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0031464Cellular componentCul4A-RING E3 ubiquitin ligase complex
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0019902Molecular functionphosphatase binding
GO_0005515Molecular functionprotein binding
GO_0005262Molecular functioncalcium channel activity

IV. Literature review

[source]
Gene nameTRPC4AP
Protein nameShort transient receptor potential channel 4-associated protein (Trp4-associated protein) (Trpc4-associated protein) (Protein TAP1) (TNF-receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS)
Alternative protein TRPC4AP
SynonymsC20orf188
TRRP4AP
DescriptionFUNCTION: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control . The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway . The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation . Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (By similarity). Involved in JNK activation via its interaction with TRAF2 (By similarity). Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1 (By similarity). .

AccessionsENST00000451813.6 [Q8TEL6-3]
ENST00000252015.3 [Q8TEL6-1]
Q8TEL6
L8E890