Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 25 studies | 31% ± 14% | |
| fibroblast | 18 studies | 25% ± 11% | |
| astrocyte | 15 studies | 31% ± 14% | |
| macrophage | 14 studies | 26% ± 12% | |
| glutamatergic neuron | 13 studies | 47% ± 23% | |
| microglial cell | 12 studies | 36% ± 14% | |
| oligodendrocyte | 12 studies | 30% ± 11% | |
| endothelial cell of lymphatic vessel | 11 studies | 26% ± 11% | |
| oligodendrocyte precursor cell | 11 studies | 33% ± 14% | |
| GABAergic neuron | 10 studies | 40% ± 19% | |
| epithelial cell | 10 studies | 36% ± 16% | |
| neuron | 9 studies | 45% ± 17% | |
| pericyte | 9 studies | 27% ± 12% | |
| adipocyte | 9 studies | 26% ± 7% | |
| retinal rod cell | 8 studies | 40% ± 14% | |
| interneuron | 7 studies | 42% ± 19% | |
| retinal cone cell | 7 studies | 37% ± 12% | |
| dendritic cell | 7 studies | 25% ± 12% | |
| smooth muscle cell | 7 studies | 23% ± 3% | |
| myeloid cell | 6 studies | 24% ± 4% | |
| basal cell | 6 studies | 29% ± 19% | |
| retina horizontal cell | 6 studies | 32% ± 11% | |
| ciliated cell | 6 studies | 24% ± 8% | |
| Mueller cell | 6 studies | 35% ± 10% | |
| natural killer cell | 6 studies | 17% ± 1% | |
| retinal bipolar neuron | 5 studies | 33% ± 10% | |
| plasmacytoid dendritic cell | 5 studies | 21% ± 5% | |
| amacrine cell | 5 studies | 30% ± 15% | |
| lymphocyte | 5 studies | 23% ± 6% | |
| endothelial cell of vascular tree | 5 studies | 31% ± 14% | |
| type I pneumocyte | 5 studies | 25% ± 9% | |
| type II pneumocyte | 5 studies | 20% ± 6% | |
| monocyte | 5 studies | 22% ± 6% | |
| goblet cell | 5 studies | 34% ± 21% | |
| club cell | 5 studies | 23% ± 7% | |
| CD16-positive, CD56-dim natural killer cell, human | 4 studies | 16% ± 1% | |
| abnormal cell | 4 studies | 26% ± 12% | |
| granule cell | 4 studies | 35% ± 14% | |
| retinal ganglion cell | 4 studies | 40% ± 6% | |
| B cell | 4 studies | 20% ± 2% | |
| cardiac muscle cell | 4 studies | 22% ± 1% | |
| vein endothelial cell | 4 studies | 34% ± 18% | |
| naive B cell | 4 studies | 17% ± 2% | |
| CD4-positive, alpha-beta T cell | 3 studies | 16% ± 1% | |
| classical monocyte | 3 studies | 20% ± 3% | |
| conventional dendritic cell | 3 studies | 20% ± 0% | |
| hematopoietic precursor cell | 3 studies | 26% ± 7% | |
| GABAergic interneuron | 3 studies | 32% ± 11% | |
| progenitor cell | 3 studies | 32% ± 5% | |
| GABAergic amacrine cell | 3 studies | 33% ± 12% | |
| OFF-bipolar cell | 3 studies | 34% ± 10% | |
| ON-bipolar cell | 3 studies | 36% ± 10% | |
| glycinergic amacrine cell | 3 studies | 40% ± 8% | |
| rod bipolar cell | 3 studies | 50% ± 14% | |
| capillary endothelial cell | 3 studies | 24% ± 4% | |
| pancreatic A cell | 3 studies | 35% ± 16% | |
| connective tissue cell | 3 studies | 27% ± 10% | |
| ependymal cell | 3 studies | 36% ± 15% | |
| enteroendocrine cell | 3 studies | 26% ± 5% | |
| intestinal crypt stem cell | 3 studies | 17% ± 2% | |
| leukocyte | 3 studies | 24% ± 3% | |
| myofibroblast cell | 3 studies | 23% ± 9% | |
| alveolar macrophage | 3 studies | 38% ± 7% | |
| gamma-delta T cell | 3 studies | 23% ± 11% | |
| transit amplifying cell | 3 studies | 37% ± 25% | |
| mast cell | 3 studies | 23% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 5467.61 | 1445 / 1445 | 100% | 40.71 | 183 / 183 |
| ovary | 100% | 6245.67 | 180 / 180 | 100% | 19.54 | 430 / 430 |
| prostate | 100% | 5883.27 | 245 / 245 | 100% | 36.78 | 502 / 502 |
| breast | 100% | 6426.27 | 459 / 459 | 100% | 42.11 | 1116 / 1118 |
| bladder | 100% | 7412.43 | 21 / 21 | 100% | 29.93 | 503 / 504 |
| lung | 100% | 6086.30 | 577 / 578 | 100% | 36.04 | 1154 / 1155 |
| brain | 99% | 3665.93 | 2628 / 2642 | 100% | 44.13 | 705 / 705 |
| intestine | 100% | 6421.25 | 966 / 966 | 99% | 32.99 | 524 / 527 |
| thymus | 100% | 8162.25 | 653 / 653 | 99% | 32.80 | 600 / 605 |
| pancreas | 100% | 4221.78 | 328 / 328 | 99% | 29.16 | 176 / 178 |
| uterus | 100% | 7044.05 | 170 / 170 | 99% | 29.99 | 453 / 459 |
| stomach | 100% | 4810.35 | 359 / 359 | 99% | 34.03 | 282 / 286 |
| adrenal gland | 100% | 6815.34 | 258 / 258 | 98% | 44.43 | 226 / 230 |
| kidney | 100% | 4308.64 | 89 / 89 | 98% | 27.65 | 882 / 901 |
| skin | 100% | 9235.09 | 1805 / 1809 | 97% | 45.00 | 459 / 472 |
| liver | 100% | 2978.55 | 226 / 226 | 94% | 15.27 | 380 / 406 |
| adipose | 100% | 7187.01 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 6872.12 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 28.34 | 29 / 29 |
| muscle | 100% | 5922.94 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5056.97 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 29.38 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.98 | 1 / 1 |
| heart | 97% | 4135.36 | 836 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 91% | 24.31 | 73 / 80 |
| peripheral blood | 83% | 4544.54 | 775 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006606 | Biological process | protein import into nucleus |
| GO_0005929 | Cellular component | cilium |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0008139 | Molecular function | nuclear localization sequence binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0031267 | Molecular function | small GTPase binding |
| GO_0061608 | Molecular function | nuclear import signal receptor activity |
| GO_0003723 | Molecular function | RNA binding |
| Gene name | TNPO1 |
| Protein name | Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP) Transportin 1 |
| Synonyms | KPNB2 MIP1 TRN |
| Description | FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates . May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 . In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). In vitro, mediates nuclear import of SRP19 . Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner . .; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. . |
| Accessions | ENST00000681711.1 A0A7P0T9C0 ENST00000680025.1 A0A7P0Z4D3 S4R398 ENST00000680533.1 ENST00000520850.5 E7EW37 Q92973 ENST00000337273.10 [Q92973-1] A0A7P0TBF0 ENST00000679378.1 A0A7P0T944 ENST00000523768.5 [Q92973-3] ENST00000605210.1 ENST00000506351.6 [Q92973-2] |