I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| plasmacytoid dendritic cell | 7 studies | 21% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| plasmacytoid dendritic cell | 7 studies | 21% ± 3% |
Insufficient scRNA-seq data for expression of TLR9 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 314.44 | 180 / 180 | 0% | 0.01 | 1 / 430 |
| uterus | 100% | 229.49 | 170 / 170 | 0% | 0.00 | 1 / 459 |
| bladder | 100% | 184.38 | 21 / 21 | 0% | 0 | 0 / 504 |
| spleen | 100% | 845.92 | 241 / 241 | 0% | 0 | 0 / 0 |
| intestine | 99% | 274.52 | 960 / 966 | 0% | 0.00 | 1 / 527 |
| peripheral blood | 99% | 1235.11 | 917 / 929 | 0% | 0 | 0 / 0 |
| prostate | 98% | 186.29 | 241 / 245 | 0% | 0 | 0 / 502 |
| blood vessel | 97% | 162.86 | 1295 / 1335 | 0% | 0 | 0 / 0 |
| lung | 97% | 141.99 | 560 / 578 | 0% | 0 | 0 / 1155 |
| muscle | 95% | 200.84 | 764 / 803 | 0% | 0 | 0 / 0 |
| adipose | 94% | 135.08 | 1136 / 1204 | 0% | 0 | 0 / 0 |
| thymus | 94% | 153.36 | 613 / 653 | 0% | 0 | 0 / 605 |
| breast | 92% | 111.04 | 423 / 459 | 0% | 0 | 0 / 1118 |
| esophagus | 91% | 131.94 | 1317 / 1445 | 0% | 0 | 0 / 183 |
| brain | 90% | 172.62 | 2385 / 2642 | 0% | 0 | 0 / 705 |
| kidney | 79% | 80.36 | 70 / 89 | 0% | 0 | 0 / 901 |
| stomach | 77% | 79.70 | 275 / 359 | 0% | 0 | 0 / 286 |
| adrenal gland | 71% | 54.66 | 182 / 258 | 0% | 0 | 0 / 230 |
| heart | 68% | 59.16 | 584 / 861 | 0% | 0 | 0 / 0 |
| skin | 60% | 52.08 | 1090 / 1809 | 0% | 0 | 0 / 472 |
| liver | 46% | 33.52 | 103 / 226 | 0% | 0 | 0 / 406 |
| pancreas | 16% | 10.13 | 51 / 328 | 0% | 0 | 0 / 178 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0045577 | Biological process | regulation of B cell differentiation |
| GO_0002755 | Biological process | MyD88-dependent toll-like receptor signaling pathway |
| GO_0050871 | Biological process | positive regulation of B cell activation |
| GO_0002224 | Biological process | toll-like receptor signaling pathway |
| GO_0032722 | Biological process | positive regulation of chemokine production |
| GO_1901224 | Biological process | positive regulation of non-canonical NF-kappaB signal transduction |
| GO_0032728 | Biological process | positive regulation of interferon-beta production |
| GO_0002639 | Biological process | positive regulation of immunoglobulin production |
| GO_0001774 | Biological process | microglial cell activation |
| GO_0030277 | Biological process | maintenance of gastrointestinal epithelium |
| GO_1905300 | Biological process | positive regulation of intestinal epithelial cell development |
| GO_0045087 | Biological process | innate immune response |
| GO_0046330 | Biological process | positive regulation of JNK cascade |
| GO_0050829 | Biological process | defense response to Gram-negative bacterium |
| GO_0007249 | Biological process | canonical NF-kappaB signal transduction |
| GO_0051607 | Biological process | defense response to virus |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0032735 | Biological process | positive regulation of interleukin-12 production |
| GO_0034162 | Biological process | toll-like receptor 9 signaling pathway |
| GO_0034163 | Biological process | regulation of toll-like receptor 9 signaling pathway |
| GO_0070373 | Biological process | negative regulation of ERK1 and ERK2 cascade |
| GO_0001932 | Biological process | regulation of protein phosphorylation |
| GO_0032733 | Biological process | positive regulation of interleukin-10 production |
| GO_0032727 | Biological process | positive regulation of interferon-alpha production |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
| GO_0032741 | Biological process | positive regulation of interleukin-18 production |
| GO_0034165 | Biological process | positive regulation of toll-like receptor 9 signaling pathway |
| GO_0032725 | Biological process | positive regulation of granulocyte macrophage colony-stimulating factor production |
| GO_0010508 | Biological process | positive regulation of autophagy |
| GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
| GO_0030890 | Biological process | positive regulation of B cell proliferation |
| GO_0071248 | Biological process | cellular response to metal ion |
| GO_0032490 | Biological process | detection of molecule of bacterial origin |
| GO_0032757 | Biological process | positive regulation of interleukin-8 production |
| GO_0002730 | Biological process | regulation of dendritic cell cytokine production |
| GO_0042742 | Biological process | defense response to bacterium |
| GO_1901895 | Biological process | negative regulation of ATPase-coupled calcium transmembrane transporter activity |
| GO_1902350 | Biological process | cellular response to chloroquine |
| GO_0071222 | Biological process | cellular response to lipopolysaccharide |
| GO_0008584 | Biological process | male gonad development |
| GO_0032729 | Biological process | positive regulation of type II interferon production |
| GO_0050729 | Biological process | positive regulation of inflammatory response |
| GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
| GO_0032755 | Biological process | positive regulation of interleukin-6 production |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0032009 | Cellular component | early phagosome |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0031901 | Cellular component | early endosome membrane |
| GO_0005764 | Cellular component | lysosome |
| GO_0036019 | Cellular component | endolysosome |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0010008 | Cellular component | endosome membrane |
| GO_0005768 | Cellular component | endosome |
| GO_0036020 | Cellular component | endolysosome membrane |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0038187 | Molecular function | pattern recognition receptor activity |
| GO_0005149 | Molecular function | interleukin-1 receptor binding |
| GO_0035197 | Molecular function | siRNA binding |
| GO_0045322 | Molecular function | unmethylated CpG binding |
| Gene name | TLR9 |
| Protein name | Alternative protein TLR9 Toll-like receptor 9 (CD antigen CD289) Toll-like receptor 9 |
| Synonyms | UNQ5798/PRO19605 |
| Description | FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production . . |
| Accessions | A0A2R4P8E0 L8E8B9 B6CH46 D1CS62 A0A2R4P858 C3W5P5 L0R5D6 ENST00000360658.3 [Q9NR96-1] D1CS61 Q9NR96 |
