TIPRL | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	13 studies	19% ± 5%	Explore
endothelial cell	10 studies	23% ± 4%	Explore
CD8-positive, alpha-beta T cell	9 studies	20% ± 3%	Explore
regulatory T cell	9 studies	17% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	19% ± 4%	Explore
fibroblast	8 studies	22% ± 6%	Explore
smooth muscle cell	8 studies	18% ± 2%	Explore
CD4-positive, alpha-beta T cell	7 studies	22% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	18% ± 2%	Explore
neuron	6 studies	23% ± 7%	Explore
mature NK T cell	5 studies	17% ± 2%	Explore
epithelial cell	5 studies	35% ± 12%	Explore
hematopoietic precursor cell	4 studies	21% ± 8%	Explore
non-classical monocyte	4 studies	25% ± 4%	Explore
classical monocyte	4 studies	21% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
exhausted T cell	4 studies	22% ± 6%	Explore
basal cell	4 studies	26% ± 12%	Explore
retina horizontal cell	4 studies	22% ± 6%	Explore
ciliated cell	4 studies	28% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	20% ± 3%	Explore
GABAergic neuron	4 studies	39% ± 14%	Explore
glutamatergic neuron	4 studies	49% ± 18%	Explore
oligodendrocyte precursor cell	4 studies	22% ± 4%	Explore
mast cell	4 studies	24% ± 8%	Explore
interneuron	4 studies	33% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	19% ± 3%	Explore
T cell	4 studies	19% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	19% ± 3%	Explore
conventional dendritic cell	3 studies	33% ± 10%	Explore
abnormal cell	3 studies	20% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
innate lymphoid cell	3 studies	16% ± 0%	Explore
macrophage	3 studies	23% ± 4%	Explore
B cell	3 studies	16% ± 1%	Explore
dendritic cell	3 studies	33% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	33% ± 19%	Explore
intestinal crypt stem cell	3 studies	16% ± 1%	Explore
plasmacytoid dendritic cell	3 studies	25% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	24% ± 10%	Explore
gamma-delta T cell	3 studies	30% ± 21%	Explore
double negative thymocyte	3 studies	26% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	4 studies	22% ± 5%	Explore
lung	4 studies	24% ± 11%	Explore
brain	4 studies	38% ± 14%	Explore
liver	3 studies	21% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	1826.74	459 / 459	100%	79.21	1118 / 1118
esophagus	100%	1952.54	1445 / 1445	100%	47.71	183 / 183
liver	100%	1292.17	226 / 226	100%	41.33	406 / 406
ovary	100%	1890.26	180 / 180	100%	49.24	430 / 430
stomach	100%	1272.76	359 / 359	100%	46.00	286 / 286
uterus	100%	2394.02	170 / 170	100%	68.26	459 / 459
lung	100%	1658.53	577 / 578	100%	61.51	1155 / 1155
bladder	100%	1986.19	21 / 21	100%	53.10	503 / 504
prostate	100%	1635.82	245 / 245	100%	44.29	501 / 502
brain	100%	1800.97	2634 / 2642	100%	53.46	705 / 705
thymus	100%	1514.69	653 / 653	100%	43.86	603 / 605
intestine	100%	2061.30	966 / 966	99%	46.94	524 / 527
skin	100%	2093.87	1808 / 1809	99%	70.93	469 / 472
adrenal gland	100%	1857.20	258 / 258	99%	37.19	228 / 230
pancreas	100%	1124.67	327 / 328	99%	44.11	176 / 178
kidney	100%	1450.83	89 / 89	96%	36.03	868 / 901
adipose	100%	1836.33	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1952.16	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	61.03	29 / 29
muscle	100%	1827.01	803 / 803	0%	0	0 / 0
spleen	100%	1634.63	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	55.52	45 / 45
ureter	0%	0	0 / 0	100%	22.92	1 / 1
heart	98%	1460.92	848 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	32.41	75 / 80
peripheral blood	90%	1543.57	836 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0031929	Biological process	TOR signaling
GO_0032515	Biological process	negative regulation of phosphoprotein phosphatase activity
GO_0000077	Biological process	DNA damage checkpoint signaling
GO_0043666	Biological process	regulation of phosphoprotein phosphatase activity
GO_0005829	Cellular component	cytosol
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TIPRL
Protein name	TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP)
Synonyms
Description	FUNCTION: May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. .
Accessions	ENST00000367833.7 [O75663-1] O75663 ENST00000367830.3 [O75663-2]

TIPRL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review