TINF2 | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	20 studies	19% ± 3%	Explore
naive B cell	14 studies	19% ± 4%	Explore
B cell	12 studies	20% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	22% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	20% ± 3%	Explore
regulatory T cell	9 studies	18% ± 3%	Explore
memory B cell	9 studies	18% ± 4%	Explore
CD8-positive, alpha-beta T cell	7 studies	19% ± 2%	Explore
mature NK T cell	7 studies	18% ± 2%	Explore
gamma-delta T cell	7 studies	21% ± 6%	Explore
endothelial cell	5 studies	24% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	20% ± 4%	Explore
CD4-positive, alpha-beta T cell	4 studies	18% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	21% ± 2%	Explore
mucosal invariant T cell	4 studies	17% ± 2%	Explore
precursor B cell	4 studies	21% ± 5%	Explore
plasmacytoid dendritic cell	4 studies	20% ± 4%	Explore
classical monocyte	3 studies	22% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
non-classical monocyte	3 studies	23% ± 4%	Explore
pericyte	3 studies	19% ± 1%	Explore
epithelial cell	3 studies	30% ± 5%	Explore
fibroblast	3 studies	22% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	16% ± 1%	Explore
T cell	3 studies	18% ± 1%	Explore
double negative thymocyte	3 studies	21% ± 5%	Explore

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	19% ± 4%	Explore
lung	5 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3933.65	1445 / 1445	100%	49.59	183 / 183
lung	100%	3944.47	578 / 578	100%	64.24	1155 / 1155
ovary	100%	2623.57	180 / 180	100%	58.75	430 / 430
stomach	100%	2637.40	359 / 359	100%	40.72	286 / 286
uterus	100%	3721.42	170 / 170	100%	73.60	459 / 459
thymus	100%	3677.11	653 / 653	100%	71.60	604 / 605
prostate	100%	3303.38	245 / 245	100%	79.92	501 / 502
breast	100%	3914.30	459 / 459	100%	78.38	1114 / 1118
intestine	100%	3274.42	966 / 966	99%	44.86	524 / 527
pancreas	99%	1879.49	326 / 328	100%	60.13	178 / 178
skin	100%	3041.14	1809 / 1809	99%	61.91	469 / 472
kidney	100%	3001.30	89 / 89	99%	53.40	894 / 901
bladder	100%	3576.86	21 / 21	99%	55.18	500 / 504
brain	99%	1879.36	2619 / 2642	100%	79.11	705 / 705
liver	100%	1329.16	226 / 226	99%	34.04	400 / 406
adrenal gland	100%	5756.02	258 / 258	98%	54.75	226 / 230
adipose	100%	4074.24	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3787.95	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	92.91	29 / 29
spleen	100%	4536.71	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	78.25	45 / 45
ureter	0%	0	0 / 0	100%	26.50	1 / 1
muscle	100%	2229.12	801 / 803	0%	0	0 / 0
peripheral blood	99%	4310.89	923 / 929	0%	0	0 / 0
heart	99%	1786.76	853 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	45.56	78 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_1904356	Biological process	regulation of telomere maintenance via telomere lengthening
GO_0032211	Biological process	negative regulation of telomere maintenance via telomerase
GO_0016233	Biological process	telomere capping
GO_0032202	Biological process	telomere assembly
GO_0070198	Biological process	protein localization to chromosome, telomeric region
GO_0032206	Biological process	positive regulation of telomere maintenance
GO_0050680	Biological process	negative regulation of epithelial cell proliferation
GO_0010836	Biological process	negative regulation of protein ADP-ribosylation
GO_0016363	Cellular component	nuclear matrix
GO_0000783	Cellular component	nuclear telomere cap complex
GO_0000781	Cellular component	chromosome, telomeric region
GO_0005654	Cellular component	nucleoplasm
GO_0016604	Cellular component	nuclear body
GO_0070187	Cellular component	shelterin complex
GO_0010370	Cellular component	perinucleolar chromocenter
GO_0003677	Molecular function	DNA binding
GO_0042162	Molecular function	telomeric DNA binding
GO_0005515	Molecular function	protein binding

Gene name	TINF2
Protein name	TERF1 (TRF1)-interacting nuclear factor 2, isoform CRA_b (TERF1 interacting nuclear factor 2) TERF1 interacting nuclear factor 2 (cDNA FLJ53728, highly similar to TERF1-interacting nuclear factor 2) TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) TERF1 interacting nuclear factor 2
Synonyms	TIN2 hCG_38254
Description	FUNCTION: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. .
Accessions	ENST00000557921.3 ENST00000699701.1 ENST00000699697.1 A0A8V8TNU6 ENST00000699687.1 ENST00000699686.1 ENST00000699695.1 A0A8V8TQE2 H0YLC9 H0YL20 H0YMN3 A0A8V8TNM8 A0A8V8TNM3 ENST00000267415.12 [Q9BSI4-1] H0YKA6 ENST00000699684.1 B4DFJ1 ENST00000646576.2 [Q9BSI4-1] ENST00000558476.5 ENST00000559019.1 Q9BSI4 ENST00000399423.8 [Q9BSI4-2] A0A8V8TQ07 ENST00000558566.1 ENST00000642983.1 [Q9BSI4-2] A0A8V8TP44 ENST00000646753.1

TINF2 report