TENT5C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045596Biological processnegative regulation of cell differentiation
GO_0048255Biological processmRNA stabilization
GO_0001701Biological processin utero embryonic development
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_1990817Molecular functionpoly(A) RNA polymerase activity
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameTENT5C
Protein nameTerminal nucleotidyltransferase 5C (EC 2.7.7.19) (Non-canonical poly(A) polymerase FAM46C)
SynonymsFAM46C
DescriptionFUNCTION: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression . Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich . Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein . .; FUNCTION: (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon. .

AccessionsQ5VWP2
ENST00000369448.4