SPPL2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031293Biological processmembrane protein intracellular domain proteolysis
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0050776Biological processregulation of immune response
GO_0006509Biological processmembrane protein ectodomain proteolysis
GO_0033619Biological processmembrane protein proteolysis
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030660Cellular componentGolgi-associated vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0031902Cellular componentlate endosome membrane
GO_0098553Cellular componentlumenal side of endoplasmic reticulum membrane
GO_0098554Cellular componentcytoplasmic side of endoplasmic reticulum membrane
GO_0005770Cellular componentlate endosome
GO_0005886Cellular componentplasma membrane
GO_0005765Cellular componentlysosomal membrane
GO_0016020Cellular componentmembrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0005515Molecular functionprotein binding
GO_0042500Molecular functionaspartic endopeptidase activity, intramembrane cleaving

IV. Literature review

[source]
Gene nameSPPL2A
Protein nameSignal peptide peptidase like 2A
Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2)
SynonymsPSL2
PSEC0147
IMP3
DescriptionFUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing . Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus . Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) . Essential for degradation of the invariant chain CD74 that plays a central role in the function of antigen-presenting cells in the immune system (By similarity). Plays a role in the regulation of innate and adaptive immunity . Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis . .

AccessionsENST00000558414.1
ENST00000698132.1
A0A8V8TLZ2
ENST00000698134.1
ENST00000698131.1
A0A8V8TLF6
ENST00000261854.10
A0A8V8TN76
H0YNA2
ENST00000559293.2
A0A8V8TLI3
A0A8V8TLY7
Q8TCT8
H0YNA7
ENST00000698133.1
ENST00000698135.1
ENST00000558934.1