SOX6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0002062Biological processchondrocyte differentiation
GO_0021529Biological processspinal cord oligodendrocyte cell differentiation
GO_0032332Biological processpositive regulation of chondrocyte differentiation
GO_2000741Biological processpositive regulation of mesenchymal stem cell differentiation
GO_2000726Biological processnegative regulation of cardiac muscle cell differentiation
GO_0045165Biological processcell fate commitment
GO_0006355Biological processregulation of DNA-templated transcription
GO_0007517Biological processmuscle organ development
GO_0007417Biological processcentral nervous system development
GO_0007420Biological processbrain development
GO_0001502Biological processcartilage condensation
GO_0051216Biological processcartilage development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0061036Biological processpositive regulation of cartilage development
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001217Molecular functionDNA-binding transcription repressor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSOX6
Protein nameTranscription factor SOX-6
SRY-box transcription factor 6
Alternative protein SOX6
Synonyms
DescriptionFUNCTION: Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). .

AccessionsENST00000316399.10 [P35712-3]
ENST00000396356.7 [P35712-3]
ENST00000528252.5 [P35712-4]
ENST00000529469.1
ENST00000527619.6 [P35712-4]
P35712
E9PQ78
E9PQL4
E9PQ67
ENST00000533411.5
ENST00000528429.5 [P35712-1]
ENST00000526673.1
L8EBC2
E9PN02
ENST00000683767.1 [P35712-1]
ENST00000530378.5
ENST00000655819.1 [P35712-2]