SOCS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0016567Biological processprotein ubiquitination
GO_0046426Biological processnegative regulation of receptor signaling pathway via JAK-STAT
GO_0030225Biological processmacrophage differentiation
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0001932Biological processregulation of protein phosphorylation
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0043377Biological processnegative regulation of CD8-positive, alpha-beta T cell differentiation
GO_0035556Biological processintracellular signal transduction
GO_0001817Biological processregulation of cytokine production
GO_0071230Biological processcellular response to amino acid stimulus
GO_0043372Biological processpositive regulation of CD4-positive, alpha-beta T cell differentiation
GO_0045591Biological processpositive regulation of regulatory T cell differentiation
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0042532Biological processnegative regulation of tyrosine phosphorylation of STAT protein
GO_0045444Biological processfat cell differentiation
GO_0005942Cellular componentphosphatidylinositol 3-kinase complex
GO_0031410Cellular componentcytoplasmic vesicle
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0004860Molecular functionprotein kinase inhibitor activity
GO_0005159Molecular functioninsulin-like growth factor receptor binding
GO_0019901Molecular functionprotein kinase binding
GO_0019210Molecular functionkinase inhibitor activity
GO_0046935Molecular function1-phosphatidylinositol-3-kinase regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSOCS1
Protein nameSuppressor of cytokine signaling 1
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
SynonymsTIP3
SSI1
hCG_14617
DescriptionFUNCTION: Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) . Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity . Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . .

AccessionsQ4JHT5
ENST00000332029.4
O15524
ENST00000644787.1