SMU1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
plasmacytoid dendritic cell	10 studies	24% ± 7%	Explore
B cell	9 studies	20% ± 5%	Explore
natural killer cell	9 studies	20% ± 2%	Explore
naive B cell	7 studies	19% ± 2%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	19% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	19% ± 2%	Explore
endothelial cell	6 studies	27% ± 3%	Explore
epithelial cell	6 studies	35% ± 18%	Explore
fibroblast	6 studies	19% ± 3%	Explore
CD8-positive, alpha-beta T cell	6 studies	19% ± 2%	Explore
memory B cell	6 studies	17% ± 2%	Explore
classical monocyte	5 studies	23% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	19% ± 3%	Explore
CD4-positive, alpha-beta T cell	5 studies	20% ± 3%	Explore
mucosal invariant T cell	5 studies	18% ± 2%	Explore
dendritic cell	5 studies	42% ± 24%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	20% ± 2%	Explore
gamma-delta T cell	5 studies	24% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	19% ± 1%	Explore
non-classical monocyte	4 studies	23% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	20% ± 3%	Explore
pericyte	4 studies	17% ± 2%	Explore
ciliated cell	4 studies	28% ± 7%	Explore
regulatory T cell	4 studies	18% ± 2%	Explore
macrophage	4 studies	20% ± 3%	Explore
glutamatergic neuron	4 studies	39% ± 14%	Explore
basal cell	4 studies	27% ± 5%	Explore
oligodendrocyte	4 studies	22% ± 2%	Explore
T cell	3 studies	17% ± 0%	Explore
mast cell	3 studies	17% ± 1%	Explore
conventional dendritic cell	3 studies	32% ± 12%	Explore
hematopoietic precursor cell	3 studies	23% ± 10%	Explore
mature NK T cell	3 studies	17% ± 1%	Explore
GABAergic neuron	3 studies	38% ± 4%	Explore
abnormal cell	3 studies	21% ± 4%	Explore
smooth muscle cell	3 studies	19% ± 3%	Explore
goblet cell	3 studies	24% ± 9%	Explore
transit amplifying cell	3 studies	22% ± 5%	Explore
neuron	3 studies	24% ± 6%	Explore
double negative thymocyte	3 studies	23% ± 6%	Explore
astrocyte	3 studies	22% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	7 studies	22% ± 7%	Explore
brain	5 studies	31% ± 8%	Explore
lung	3 studies	25% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	3875.61	459 / 459	100%	45.42	1118 / 1118
esophagus	100%	3641.20	1445 / 1445	100%	29.00	183 / 183
lung	100%	3422.92	578 / 578	100%	34.37	1155 / 1155
prostate	100%	3584.65	245 / 245	100%	39.95	502 / 502
stomach	100%	2716.48	359 / 359	100%	29.44	286 / 286
thymus	100%	3330.97	653 / 653	100%	39.77	605 / 605
uterus	100%	4383.29	170 / 170	100%	40.32	459 / 459
brain	100%	3016.93	2639 / 2642	100%	44.34	705 / 705
intestine	100%	3713.65	966 / 966	100%	31.72	526 / 527
bladder	100%	3837.57	21 / 21	100%	33.16	503 / 504
kidney	100%	2359.66	89 / 89	100%	28.22	899 / 901
ovary	100%	4251.24	180 / 180	100%	26.15	429 / 430
liver	100%	1700.97	225 / 226	100%	18.71	404 / 406
skin	100%	4643.79	1809 / 1809	99%	31.87	467 / 472
adrenal gland	100%	3738.85	258 / 258	99%	27.65	227 / 230
pancreas	99%	1622.09	324 / 328	99%	28.09	177 / 178
adipose	100%	3877.33	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3827.89	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	43.45	29 / 29
muscle	100%	2819.43	803 / 803	0%	0	0 / 0
spleen	100%	3924.71	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	40.85	45 / 45
ureter	0%	0	0 / 0	100%	16.16	1 / 1
heart	99%	2294.82	851 / 861	0%	0	0 / 0
peripheral blood	97%	2905.27	897 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	96%	24.53	77 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0008380	Biological process	RNA splicing
GO_0000381	Biological process	regulation of alternative mRNA splicing, via spliceosome
GO_0016607	Cellular component	nuclear speck
GO_0071011	Cellular component	precatalytic spliceosome
GO_0005654	Cellular component	nucleoplasm
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SMU1
Protein name	WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) [Cleaved into: WD40 repeat-containing protein SMU1, N-terminally processed]
Synonyms	hCG_30278
Description	FUNCTION: Involved in pre-mRNA splicing as a component of the spliceosome . Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK . Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity). .; FUNCTION: (Microbial infection) Required, together with IK, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles. .
Accessions	Q2TAY7 A0MNN4 ENST00000397149.4 [Q2TAY7-1]

SMU1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review