Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 19 studies | 33% ± 14% | |
astrocyte | 14 studies | 33% ± 15% | |
fibroblast | 12 studies | 36% ± 13% | |
microglial cell | 11 studies | 31% ± 15% | |
oligodendrocyte | 11 studies | 28% ± 11% | |
glutamatergic neuron | 10 studies | 41% ± 25% | |
macrophage | 9 studies | 30% ± 12% | |
oligodendrocyte precursor cell | 9 studies | 26% ± 11% | |
adipocyte | 9 studies | 30% ± 8% | |
GABAergic neuron | 8 studies | 44% ± 21% | |
pericyte | 8 studies | 29% ± 12% | |
smooth muscle cell | 8 studies | 30% ± 8% | |
T cell | 7 studies | 24% ± 4% | |
epithelial cell | 7 studies | 32% ± 18% | |
neuron | 6 studies | 37% ± 17% | |
interneuron | 6 studies | 43% ± 22% | |
retinal cone cell | 6 studies | 27% ± 9% | |
endothelial cell of lymphatic vessel | 6 studies | 35% ± 10% | |
natural killer cell | 5 studies | 22% ± 5% | |
CD4-positive, alpha-beta T cell | 5 studies | 21% ± 4% | |
cardiac muscle cell | 5 studies | 28% ± 6% | |
dendritic cell | 5 studies | 21% ± 4% | |
ciliated cell | 5 studies | 26% ± 8% | |
type I pneumocyte | 5 studies | 31% ± 7% | |
type II pneumocyte | 5 studies | 25% ± 6% | |
basal cell | 5 studies | 32% ± 20% | |
CD8-positive, alpha-beta T cell | 4 studies | 19% ± 3% | |
effector memory CD8-positive, alpha-beta T cell | 4 studies | 21% ± 2% | |
granule cell | 4 studies | 25% ± 4% | |
lymphocyte | 4 studies | 34% ± 11% | |
Mueller cell | 4 studies | 20% ± 3% | |
retina horizontal cell | 4 studies | 16% ± 1% | |
retinal rod cell | 4 studies | 23% ± 4% | |
myeloid cell | 4 studies | 24% ± 7% | |
monocyte | 4 studies | 26% ± 5% | |
club cell | 4 studies | 29% ± 9% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 20% ± 3% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 22% ± 2% | |
GABAergic interneuron | 3 studies | 28% ± 7% | |
plasma cell | 3 studies | 28% ± 5% | |
mesothelial cell | 3 studies | 28% ± 9% | |
vein endothelial cell | 3 studies | 31% ± 17% | |
endothelial cell of vascular tree | 3 studies | 31% ± 14% | |
ependymal cell | 3 studies | 35% ± 11% | |
alveolar macrophage | 3 studies | 30% ± 8% | |
respiratory goblet cell | 3 studies | 32% ± 13% | |
muscle cell | 3 studies | 31% ± 20% | |
goblet cell | 3 studies | 39% ± 27% | |
transit amplifying cell | 3 studies | 37% ± 29% | |
mural cell | 3 studies | 33% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1896.71 | 1444 / 1445 | 100% | 10.03 | 183 / 183 |
brain | 100% | 1545.82 | 2637 / 2642 | 99% | 14.47 | 695 / 705 |
skin | 100% | 2044.48 | 1808 / 1809 | 96% | 9.25 | 454 / 472 |
lung | 100% | 1502.34 | 577 / 578 | 96% | 6.93 | 1107 / 1155 |
stomach | 100% | 1173.18 | 359 / 359 | 95% | 6.54 | 273 / 286 |
intestine | 100% | 1644.36 | 966 / 966 | 94% | 5.63 | 498 / 527 |
breast | 100% | 1675.99 | 459 / 459 | 94% | 8.88 | 1056 / 1118 |
prostate | 100% | 1866.63 | 245 / 245 | 93% | 8.64 | 469 / 502 |
thymus | 100% | 1700.01 | 653 / 653 | 93% | 10.56 | 563 / 605 |
kidney | 100% | 1092.55 | 89 / 89 | 91% | 8.02 | 819 / 901 |
pancreas | 96% | 633.13 | 316 / 328 | 94% | 6.19 | 167 / 178 |
bladder | 100% | 1903.05 | 21 / 21 | 87% | 5.21 | 438 / 504 |
uterus | 100% | 2485.75 | 170 / 170 | 85% | 5.55 | 389 / 459 |
ovary | 100% | 2696.62 | 180 / 180 | 82% | 5.40 | 354 / 430 |
adrenal gland | 100% | 1577.71 | 258 / 258 | 77% | 5.46 | 177 / 230 |
liver | 84% | 396.52 | 190 / 226 | 49% | 2.02 | 200 / 406 |
adipose | 100% | 1605.62 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1982.13 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1051.85 | 241 / 241 | 0% | 0 | 0 / 0 |
muscle | 100% | 1228.38 | 802 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 9.69 | 79 / 80 |
heart | 97% | 1060.94 | 832 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 7.66 | 41 / 45 |
peripheral blood | 82% | 857.09 | 765 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 59% | 4.06 | 17 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0032204 | Biological process | regulation of telomere maintenance |
GO_0051972 | Biological process | regulation of telomerase activity |
GO_0000184 | Biological process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
GO_0006406 | Biological process | mRNA export from nucleus |
GO_1904354 | Biological process | negative regulation of telomere capping |
GO_0032210 | Biological process | regulation of telomere maintenance via telomerase |
GO_0035303 | Biological process | regulation of dephosphorylation |
GO_0005730 | Cellular component | nucleolus |
GO_0035145 | Cellular component | exon-exon junction complex |
GO_0005697 | Cellular component | telomerase holoenzyme complex |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0005634 | Cellular component | nucleus |
GO_0004521 | Molecular function | RNA endonuclease activity |
GO_0070182 | Molecular function | DNA polymerase binding |
GO_0042162 | Molecular function | telomeric DNA binding |
GO_0043021 | Molecular function | ribonucleoprotein complex binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0003723 | Molecular function | RNA binding |
GO_0070034 | Molecular function | telomerase RNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | SMG6 |
Protein name | SMG6 nonsense mediated mRNA decay factor Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) |
Synonyms | C17orf31 KIAA0732 EST1A |
Description | FUNCTION: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini . May have a general role in telomere regulation . Promotes in vitro the ability of TERT to elongate telomeres . Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization . Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) . .; FUNCTION: Plays a role in nonsense-mediated mRNA decay . Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation . Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA . . |
Accessions | I3L1W8 ENST00000572369.5 K7EKV2 ENST00000354901.8 [Q86US8-3] I3L355 ENST00000570606.5 ENST00000575176.5 I3L176 ENST00000536871.6 [Q86US8-3] ENST00000570668.1 ENST00000571442.5 K7ELM2 ENST00000570659.5 Q86US8 I3L390 ENST00000263073.11 [Q86US8-1] I3L421 ENST00000575663.5 K7ENH7 ENST00000572205.5 ENST00000575454.1 I3L3A9 |