SKIC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070478Biological processnuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
GO_0000956Biological processnuclear-transcribed mRNA catabolic process
GO_0072344Biological processrescue of stalled ribosome
GO_0055087Cellular componentSki complex
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSKIC3
Protein nameSKI3 subunit of superkiller complex
Superkiller complex protein 3 (Ski3) (Tetratricopeptide repeat protein 37) (TPR repeat protein 37) (Tricho-hepatic-enteric syndrome protein) (Thespin)
SynonymsTTC37
KIAA0372
DescriptionFUNCTION: Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways . The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation . SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling . In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) . .

AccessionsA0A8V8TNJ9
A0A8V8TNA2
ENST00000698494.1
H0Y964
ENST00000698485.1
ENST00000698492.1
A0A8V8TM98
ENST00000698455.1
ENST00000513823.5
ENST00000698454.1
ENST00000698469.1
D6RCE2
ENST00000358746.7
ENST00000698460.1
ENST00000698490.1
ENST00000698479.1
ENST00000698476.1
A0A8V8TNK4
ENST00000513232.2
ENST00000698459.1
H0Y915
ENST00000698453.1
A0A8V8TNJ4
ENST00000698458.1
A0A8V8TMA8
ENST00000698477.1
ENST00000698481.1
Q6PGP7
A0A8V8TLT7
A0A8V8TN82
A0A8V8TLS3
ENST00000698470.1
A0A8V8TLU5
ENST00000698457.1
ENST00000698480.1
ENST00000505578.5
ENST00000514952.5
ENST00000698484.1
ENST00000698487.1
A0A8V8TNK9
ENST00000698488.1
ENST00000649566.1
D6RDA0
ENST00000698472.1
A0A8V8TMA3
A0A8V8TLR0
A0A8V8TN92
A0A8V8TLT2
A0A8V8TLU2
A0A8V8TMB2
ENST00000698456.1