Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 20 studies | 29% ± 13% | |
astrocyte | 12 studies | 33% ± 16% | |
fibroblast | 12 studies | 26% ± 8% | |
glutamatergic neuron | 10 studies | 51% ± 24% | |
oligodendrocyte | 10 studies | 40% ± 13% | |
macrophage | 10 studies | 28% ± 11% | |
type I pneumocyte | 9 studies | 23% ± 7% | |
GABAergic neuron | 9 studies | 44% ± 23% | |
pericyte | 9 studies | 27% ± 13% | |
epithelial cell | 9 studies | 33% ± 18% | |
B cell | 8 studies | 19% ± 5% | |
microglial cell | 8 studies | 31% ± 10% | |
oligodendrocyte precursor cell | 8 studies | 41% ± 17% | |
adipocyte | 8 studies | 28% ± 5% | |
retinal ganglion cell | 7 studies | 38% ± 18% | |
smooth muscle cell | 7 studies | 22% ± 4% | |
plasmacytoid dendritic cell | 7 studies | 22% ± 8% | |
neuron | 6 studies | 44% ± 10% | |
myeloid cell | 6 studies | 21% ± 5% | |
basal cell | 6 studies | 28% ± 16% | |
ciliated cell | 6 studies | 23% ± 7% | |
endothelial cell of lymphatic vessel | 6 studies | 25% ± 7% | |
natural killer cell | 5 studies | 18% ± 3% | |
interneuron | 5 studies | 59% ± 20% | |
club cell | 5 studies | 22% ± 5% | |
retina horizontal cell | 5 studies | 25% ± 9% | |
mast cell | 5 studies | 20% ± 4% | |
amacrine cell | 5 studies | 26% ± 11% | |
CD4-positive, alpha-beta T cell | 4 studies | 17% ± 1% | |
capillary endothelial cell | 4 studies | 19% ± 1% | |
granule cell | 4 studies | 39% ± 5% | |
cardiac muscle cell | 4 studies | 20% ± 1% | |
lymphocyte | 4 studies | 26% ± 7% | |
OFF-bipolar cell | 4 studies | 23% ± 7% | |
ON-bipolar cell | 4 studies | 23% ± 9% | |
type II pneumocyte | 4 studies | 22% ± 6% | |
dendritic cell | 4 studies | 26% ± 9% | |
connective tissue cell | 4 studies | 20% ± 5% | |
T cell | 4 studies | 18% ± 3% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 15% ± 0% | |
glomerular endothelial cell | 3 studies | 17% ± 0% | |
glial cell | 3 studies | 24% ± 6% | |
plasma cell | 3 studies | 34% ± 6% | |
retinal bipolar neuron | 3 studies | 19% ± 3% | |
GABAergic amacrine cell | 3 studies | 27% ± 10% | |
Mueller cell | 3 studies | 21% ± 8% | |
glycinergic amacrine cell | 3 studies | 28% ± 8% | |
retinal rod cell | 3 studies | 19% ± 2% | |
rod bipolar cell | 3 studies | 24% ± 9% | |
respiratory goblet cell | 3 studies | 19% ± 1% | |
endothelial cell of vascular tree | 3 studies | 24% ± 12% | |
hepatocyte | 3 studies | 27% ± 11% | |
enteroendocrine cell | 3 studies | 22% ± 5% | |
myofibroblast cell | 3 studies | 24% ± 9% | |
monocyte | 3 studies | 19% ± 2% | |
transit amplifying cell | 3 studies | 38% ± 27% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 4412.34 | 1445 / 1445 | 100% | 26.66 | 183 / 183 |
breast | 100% | 5015.24 | 459 / 459 | 99% | 34.73 | 1112 / 1118 |
lung | 100% | 4675.98 | 577 / 578 | 100% | 20.31 | 1150 / 1155 |
brain | 99% | 4396.48 | 2616 / 2642 | 100% | 26.57 | 704 / 705 |
thymus | 100% | 4755.02 | 653 / 653 | 99% | 25.54 | 596 / 605 |
prostate | 100% | 5360.37 | 245 / 245 | 98% | 34.37 | 494 / 502 |
stomach | 100% | 4716.86 | 359 / 359 | 98% | 21.35 | 280 / 286 |
bladder | 100% | 4754.29 | 21 / 21 | 98% | 18.49 | 493 / 504 |
intestine | 100% | 4878.40 | 966 / 966 | 98% | 20.68 | 514 / 527 |
adrenal gland | 100% | 5956.10 | 258 / 258 | 97% | 22.60 | 224 / 230 |
uterus | 100% | 5604.18 | 170 / 170 | 97% | 20.87 | 447 / 459 |
ovary | 100% | 5847.79 | 180 / 180 | 97% | 13.77 | 418 / 430 |
pancreas | 100% | 3708.35 | 328 / 328 | 97% | 20.67 | 173 / 178 |
kidney | 100% | 3569.84 | 89 / 89 | 97% | 28.48 | 874 / 901 |
skin | 100% | 7759.04 | 1808 / 1809 | 93% | 27.86 | 440 / 472 |
liver | 100% | 2150.42 | 225 / 226 | 94% | 15.07 | 380 / 406 |
blood vessel | 100% | 5184.17 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 4925.94 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 4430.59 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 4916.37 | 1203 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 21.22 | 43 / 45 |
heart | 95% | 3215.07 | 819 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 86% | 16.15 | 25 / 29 |
eye | 0% | 0 | 0 / 0 | 68% | 12.14 | 54 / 80 |
peripheral blood | 54% | 2300.84 | 506 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0070478 | Biological process | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
GO_0000956 | Biological process | nuclear-transcribed mRNA catabolic process |
GO_0072344 | Biological process | rescue of stalled ribosome |
GO_0055087 | Cellular component | Ski complex |
GO_0000791 | Cellular component | euchromatin |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
Gene name | SKIC3 |
Protein name | SKI3 subunit of superkiller complex Superkiller complex protein 3 (Ski3) (Tetratricopeptide repeat protein 37) (TPR repeat protein 37) (Tricho-hepatic-enteric syndrome protein) (Thespin) |
Synonyms | TTC37 KIAA0372 |
Description | FUNCTION: Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways . The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation . SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling . In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) . . |
Accessions | A0A8V8TNJ9 A0A8V8TNA2 ENST00000698494.1 H0Y964 ENST00000698485.1 ENST00000698492.1 A0A8V8TM98 ENST00000698455.1 ENST00000513823.5 ENST00000698454.1 ENST00000698469.1 D6RCE2 ENST00000358746.7 ENST00000698460.1 ENST00000698490.1 ENST00000698479.1 ENST00000698476.1 A0A8V8TNK4 ENST00000513232.2 ENST00000698459.1 H0Y915 ENST00000698453.1 A0A8V8TNJ4 ENST00000698458.1 A0A8V8TMA8 ENST00000698477.1 ENST00000698481.1 Q6PGP7 A0A8V8TLT7 A0A8V8TN82 A0A8V8TLS3 ENST00000698470.1 A0A8V8TLU5 ENST00000698457.1 ENST00000698480.1 ENST00000505578.5 ENST00000514952.5 ENST00000698484.1 ENST00000698487.1 A0A8V8TNK9 ENST00000698488.1 ENST00000649566.1 D6RDA0 ENST00000698472.1 A0A8V8TMA3 A0A8V8TLR0 A0A8V8TN92 A0A8V8TLT2 A0A8V8TLU2 A0A8V8TMB2 ENST00000698456.1 |