Biological process

3'-5' NMD, 3'-5' nonsense-mediated decay, 3'-5' nonsense-mediated mRNA decay, nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA degradation, 3'-5' exonucleolytic nonsense-mediated decay

The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.