SKIC8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045638Biological processnegative regulation of myeloid cell differentiation
GO_0070478Biological processnuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0016055Biological processWnt signaling pathway
GO_0072344Biological processrescue of stalled ribosome
GO_0055087Cellular componentSki complex
GO_0000791Cellular componenteuchromatin
GO_0016593Cellular componentCdc73/Paf1 complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSKIC8
Protein nameSuperkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)]
SKI8 subunit of superkiller complex
Superkiller complex protein 8 (WD repeat-containing protein 61)
SynonymsWDR61
DescriptionFUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency . PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1 . PAF1C is required for transcription of Hox and Wnt target genes . PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL . PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3) . PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription . PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors . In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription . Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription . Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways . The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation . SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling . .

AccessionsH0YLA1
H3BQA8
ENST00000560807.5
ENST00000558459.5
H0YM76
ENST00000558311.5
ENST00000560610.5
H0YL19
Q9GZS3
H0YN81
ENST00000558453.5
ENST00000560569.5
H0YMF9
ENST00000267973.7
ENST00000559848.1