Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 27% ± 9% | |
fibroblast | 10 studies | 24% ± 11% | |
ciliated cell | 10 studies | 28% ± 9% | |
epithelial cell | 7 studies | 37% ± 13% | |
plasmacytoid dendritic cell | 6 studies | 21% ± 6% | |
astrocyte | 5 studies | 25% ± 5% | |
basal cell | 5 studies | 28% ± 11% | |
classical monocyte | 4 studies | 21% ± 4% | |
retina horizontal cell | 4 studies | 27% ± 10% | |
GABAergic neuron | 4 studies | 41% ± 13% | |
glutamatergic neuron | 4 studies | 50% ± 15% | |
oligodendrocyte | 4 studies | 25% ± 5% | |
conventional dendritic cell | 3 studies | 37% ± 13% | |
hematopoietic precursor cell | 3 studies | 28% ± 6% | |
non-classical monocyte | 3 studies | 25% ± 5% | |
kidney loop of Henle epithelial cell | 3 studies | 18% ± 1% | |
connective tissue cell | 3 studies | 20% ± 4% | |
Mueller cell | 3 studies | 20% ± 1% | |
rod bipolar cell | 3 studies | 24% ± 6% | |
erythroblast | 3 studies | 33% ± 12% | |
abnormal cell | 3 studies | 22% ± 4% | |
macrophage | 3 studies | 24% ± 5% | |
oligodendrocyte precursor cell | 3 studies | 28% ± 8% | |
dendritic cell | 3 studies | 40% ± 10% | |
goblet cell | 3 studies | 20% ± 4% | |
intestinal crypt stem cell | 3 studies | 22% ± 2% | |
club cell | 3 studies | 24% ± 9% | |
transit amplifying cell | 3 studies | 25% ± 7% | |
interneuron | 3 studies | 41% ± 18% | |
neuron | 3 studies | 31% ± 7% | |
natural killer cell | 3 studies | 18% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2003.68 | 1445 / 1445 | 100% | 13.49 | 183 / 183 |
ovary | 100% | 2045.24 | 180 / 180 | 100% | 15.22 | 430 / 430 |
pancreas | 100% | 1320.33 | 328 / 328 | 100% | 15.79 | 178 / 178 |
brain | 100% | 1931.76 | 2638 / 2642 | 100% | 22.37 | 705 / 705 |
lung | 100% | 1861.55 | 577 / 578 | 100% | 18.64 | 1155 / 1155 |
breast | 100% | 2691.10 | 459 / 459 | 100% | 24.48 | 1116 / 1118 |
uterus | 100% | 2260.69 | 170 / 170 | 100% | 19.57 | 458 / 459 |
thymus | 100% | 2778.49 | 653 / 653 | 100% | 22.16 | 603 / 605 |
stomach | 100% | 1679.18 | 359 / 359 | 100% | 14.81 | 285 / 286 |
intestine | 100% | 1936.41 | 966 / 966 | 100% | 17.84 | 525 / 527 |
prostate | 100% | 2437.96 | 245 / 245 | 100% | 22.76 | 500 / 502 |
skin | 100% | 2466.69 | 1809 / 1809 | 100% | 26.17 | 470 / 472 |
bladder | 100% | 1988.86 | 21 / 21 | 99% | 17.96 | 501 / 504 |
kidney | 100% | 2318.49 | 89 / 89 | 99% | 15.38 | 895 / 901 |
liver | 100% | 1150.74 | 225 / 226 | 100% | 12.22 | 405 / 406 |
adrenal gland | 100% | 3006.07 | 258 / 258 | 99% | 20.78 | 227 / 230 |
adipose | 100% | 2430.54 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 19.75 | 29 / 29 |
spleen | 100% | 1924.80 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 17.61 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 11.55 | 1 / 1 |
blood vessel | 100% | 2244.37 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 1576.68 | 800 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 1329.09 | 838 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 95% | 14.84 | 76 / 80 |
peripheral blood | 81% | 1101.32 | 750 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045638 | Biological process | negative regulation of myeloid cell differentiation |
GO_0070478 | Biological process | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
GO_0006368 | Biological process | transcription elongation by RNA polymerase II |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0072344 | Biological process | rescue of stalled ribosome |
GO_0055087 | Cellular component | Ski complex |
GO_0000791 | Cellular component | euchromatin |
GO_0016593 | Cellular component | Cdc73/Paf1 complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
Gene name | SKIC8 |
Protein name | Superkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)] SKI8 subunit of superkiller complex Superkiller complex protein 8 (WD repeat-containing protein 61) |
Synonyms | WDR61 |
Description | FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency . PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1 . PAF1C is required for transcription of Hox and Wnt target genes . PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL . PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3) . PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription . PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors . In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription . Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription . Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways . The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation . SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling . . |
Accessions | H0YLA1 H3BQA8 ENST00000560807.5 ENST00000558459.5 H0YM76 ENST00000558311.5 ENST00000560610.5 H0YL19 Q9GZS3 H0YN81 ENST00000558453.5 ENST00000560569.5 H0YMF9 ENST00000267973.7 ENST00000559848.1 |