SKIC2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SKIC2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SKIC2 at tissue level.

III. Associated gene sets

GO_0070478Biological processnuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
GO_0072344Biological processrescue of stalled ribosome
GO_0055087Cellular componentSki complex
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0034458Molecular function3'-5' RNA helicase activity
GO_0005515Molecular functionprotein binding
GO_0003724Molecular functionRNA helicase activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameSKIC2
Protein nameSKIV2L (Superkiller viralicidic activity 2-like (S. cerevisiae))
SKI2 subunit of superkiller complex (cDNA FLJ61010, highly similar to Helicase SKI2W)
DJ34F7.7 (Superkiller viralicidic activity 2 (S. cerevisiae homolog)-like (SKI2W))
SKI2 subunit of superkiller complex
SKIV2L (Superkiller viralicidic activity 2-like (S. cerevisiae), isoform CRA_c)
Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP)
SynonymshCG_43698
SKIV2
W
DDX13
SKI2W
SKIV2L
DescriptionFUNCTION: Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways . The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation . SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling . In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) . .

AccessionsQ96BC0
ENST00000627683.1
ENST00000448219.4
ENST00000697831.1
A0A8V8TLC0
A0A8V8TN04
ENST00000375394.7
A0A8V8TLA2
A0A8V8TLR3
ENST00000383336.6
A0A1U9X8J0
Q9NPK3
ENST00000491994.2
A0A8V8TL97
ENST00000697840.1
ENST00000697837.1
ENST00000697835.1
Q15477
B4E0B4
ENST00000429465.4
ENST00000474839.5
ENST00000697833.1
F8WDE8
ENST00000461073.6
A0A8V8TMR3
ENST00000626668.1
ENST00000627041.1
ENST00000421789.4
ENST00000626050.1
ENST00000697838.1
H7C4L3
ENST00000627011.1
ENST00000483553.6
ENST00000412823.4
H7C5N0