RUNX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0050673Biological processepithelial cell proliferation
GO_0007224Biological processsmoothened signaling pathway
GO_0030097Biological processhemopoiesis
GO_0002051Biological processosteoblast fate commitment
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0001649Biological processosteoblast differentiation
GO_0010628Biological processpositive regulation of gene expression
GO_0002062Biological processchondrocyte differentiation
GO_0032332Biological processpositive regulation of chondrocyte differentiation
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_2000648Biological processpositive regulation of stem cell proliferation
GO_0072089Biological processstem cell proliferation
GO_0001958Biological processendochondral ossification
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0035115Biological processembryonic forelimb morphogenesis
GO_1904383Biological processresponse to sodium phosphate
GO_0002063Biological processchondrocyte development
GO_0030509Biological processBMP signaling pathway
GO_0030217Biological processT cell differentiation
GO_0030182Biological processneuron differentiation
GO_0060395Biological processSMAD protein signal transduction
GO_0036076Biological processligamentous ossification
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045595Biological processregulation of cell differentiation
GO_0042487Biological processregulation of odontogenesis of dentin-containing tooth
GO_0030282Biological processbone mineralization
GO_0048701Biological processembryonic cranial skeleton morphogenesis
GO_0010467Biological processgene expression
GO_0040036Biological processregulation of fibroblast growth factor receptor signaling pathway
GO_0001503Biological processossification
GO_0048863Biological processstem cell differentiation
GO_0030278Biological processregulation of ossification
GO_0048469Biological processcell maturation
GO_0002076Biological processosteoblast development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043425Molecular functionbHLH transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0019904Molecular functionprotein domain specific binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005524Molecular functionATP binding
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRUNX2
Protein nameTruncated core binding factor alpha1
Alternative protein RUNX2
Runt-related transcription factor
RUNX2 protein
Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit)
RUNX family transcription factor 2
SynonymsPEBP2A
OSF2
CBFA1
AML3
DescriptionFUNCTION: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis . Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. .

FUNCTION: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. .

AccessionsI3L354
U3RG86
ENST00000371432.7 [Q13950-3]
ENST00000483377.5
A0A0D9SEN7
ENST00000646519.1
ENST00000359524.7 [Q13950-2]
ENST00000478660.6
I3L4L9
Q13950
ENST00000576263.5
ENST00000647337.2 [Q13950-1]
ENST00000625924.1
L8E7D8
I3L0L0
ENST00000371438.5 [Q13950-1]
ENST00000371436.10 [Q13950-3]
A0A2R8Y7Z3
Q32MY8