PSENEN | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	16 studies	74% ± 15%	Explore
conventional dendritic cell	12 studies	24% ± 10%	Explore
plasmacytoid dendritic cell	12 studies	29% ± 10%	Explore
natural killer cell	11 studies	20% ± 4%	Explore
macrophage	11 studies	26% ± 9%	Explore
plasma cell	10 studies	29% ± 12%	Explore
epithelial cell	9 studies	36% ± 22%	Explore
non-classical monocyte	9 studies	28% ± 8%	Explore
fibroblast	9 studies	24% ± 11%	Explore
monocyte	9 studies	20% ± 7%	Explore
classical monocyte	8 studies	26% ± 7%	Explore
endothelial cell	8 studies	26% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	17% ± 2%	Explore
CD8-positive, alpha-beta T cell	6 studies	18% ± 2%	Explore
endothelial cell of lymphatic vessel	6 studies	25% ± 9%	Explore
abnormal cell	5 studies	22% ± 11%	Explore
myeloid cell	5 studies	24% ± 10%	Explore
basal cell	5 studies	37% ± 21%	Explore
deuterosomal cell	4 studies	55% ± 14%	Explore
mature NK T cell	4 studies	18% ± 1%	Explore
capillary endothelial cell	4 studies	18% ± 3%	Explore
epithelial cell of proximal tubule	4 studies	20% ± 5%	Explore
T cell	4 studies	19% ± 4%	Explore
connective tissue cell	4 studies	18% ± 2%	Explore
pericyte	4 studies	21% ± 3%	Explore
dendritic cell	4 studies	35% ± 14%	Explore
plasmablast	3 studies	50% ± 14%	Explore
pancreatic A cell	3 studies	40% ± 16%	Explore
leukocyte	3 studies	19% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	19% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
hematopoietic precursor cell	3 studies	23% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	17% ± 1%	Explore
endothelial cell of artery	3 studies	16% ± 0%	Explore
smooth muscle cell	3 studies	21% ± 4%	Explore
club cell	3 studies	23% ± 5%	Explore
kidney loop of Henle epithelial cell	3 studies	19% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	24% ± 8%	Explore
goblet cell	3 studies	30% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	20% ± 6%	Explore
gamma-delta T cell	3 studies	24% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	9 studies	29% ± 12%	Explore
peripheral blood	7 studies	19% ± 3%	Explore
kidney	4 studies	16% ± 0%	Explore
pancreas	3 studies	36% ± 10%	Explore
brain	3 studies	25% ± 3%	Explore
intestine	3 studies	22% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	1749.00	258 / 258	100%	39.38	230 / 230
ovary	100%	1021.68	180 / 180	100%	99.83	430 / 430
thymus	100%	1740.70	653 / 653	100%	42.34	605 / 605
uterus	100%	1332.02	170 / 170	100%	57.09	459 / 459
skin	100%	1307.22	1808 / 1809	100%	37.84	472 / 472
esophagus	100%	1329.38	1445 / 1445	99%	30.52	182 / 183
prostate	100%	1321.97	245 / 245	99%	33.09	499 / 502
breast	100%	1463.05	459 / 459	99%	58.02	1111 / 1118
stomach	100%	1143.59	359 / 359	99%	38.19	284 / 286
liver	100%	1122.25	226 / 226	99%	31.38	403 / 406
intestine	100%	1344.45	966 / 966	99%	39.06	522 / 527
pancreas	100%	984.57	328 / 328	99%	43.25	176 / 178
bladder	100%	1261.76	21 / 21	99%	54.92	498 / 504
lung	100%	1596.19	578 / 578	99%	39.69	1139 / 1155
brain	100%	1335.91	2640 / 2642	98%	30.90	694 / 705
kidney	100%	1773.03	89 / 89	98%	29.50	879 / 901
adipose	100%	1334.89	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	36.71	80 / 80
lymph node	0%	0	0 / 0	100%	35.54	29 / 29
spleen	100%	1574.49	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	32.47	45 / 45
ureter	0%	0	0 / 0	100%	57.10	1 / 1
blood vessel	100%	1171.66	1332 / 1335	0%	0	0 / 0
peripheral blood	100%	2150.11	925 / 929	0%	0	0 / 0
heart	99%	975.12	854 / 861	0%	0	0 / 0
muscle	99%	856.30	796 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007220	Biological process	Notch receptor processing
GO_0031293	Biological process	membrane protein intracellular domain proteolysis
GO_0007219	Biological process	Notch signaling pathway
GO_0016485	Biological process	protein processing
GO_0042982	Biological process	amyloid precursor protein metabolic process
GO_0010950	Biological process	positive regulation of endopeptidase activity
GO_0042987	Biological process	amyloid precursor protein catabolic process
GO_0034205	Biological process	amyloid-beta formation
GO_0006509	Biological process	membrane protein ectodomain proteolysis
GO_0070765	Cellular component	gamma-secretase complex
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0042734	Cellular component	presynaptic membrane
GO_0000139	Cellular component	Golgi membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0010008	Cellular component	endosome membrane
GO_0032580	Cellular component	Golgi cisterna membrane
GO_0019899	Molecular function	enzyme binding
GO_0061133	Molecular function	endopeptidase activator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PSENEN
Protein name	Gamma-secretase subunit PEN-2 Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2)
Synonyms	PEN2 MDS033
Description	FUNCTION: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) . The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity . .
Accessions	ENST00000587708.7 Q9NZ42 ENST00000591949.1 ENST00000222266.2 K7ES79

PSENEN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review