PPP4R3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0006470Biological processprotein dephosphorylation
GO_0016607Cellular componentnuclear speck
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0030289Cellular componentprotein phosphatase 4 complex
GO_0072542Molecular functionprotein phosphatase activator activity

IV. Literature review

[source]
Gene namePPP4R3A
Protein nameSerine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1)
SMEK1 protein
SMEK homolog 1
Protein phosphatase 4 regulatory subunit 3A
SynonymsPP4R3A
MSTP033
KIAA2010
SMEK1
DescriptionFUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. .

AccessionsENST00000554390.5
H0YIY8
G3V4R3
H0YJN6
G3V5A2
G3V5Z3
ENST00000555029.5
ENST00000555470.1
G3V231
ENST00000554308.5
Q8N6W1
ENST00000554511.1
ENST00000555462.5 [Q6IN85-4]
ENST00000554684.5 [Q6IN85-2]
Q6IN85
ENST00000554943.6 [Q6IN85-1]
ENST00000557018.5