PPM1K report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035970Biological processpeptidyl-threonine dephosphorylation
GO_1902108Biological processregulation of mitochondrial membrane permeability involved in apoptotic process
GO_0009083Biological processbranched-chain amino acid catabolic process
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0030145Molecular functionmanganese ion binding
GO_0047385Molecular function[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity
GO_0017018Molecular functionmyosin phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity

IV. Literature review

[source]
Gene namePPM1K
Protein nameProtein phosphatase, Mg2+/Mn2+ dependent 1K
Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (EC 3.1.3.52) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (Protein phosphatase 2C family member)
Protein phosphatase 1G
protein-serine/threonine phosphatase (EC 3.1.3.16)
Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial)
SynonymsPP2CM
hCG_39060
DescriptionFUNCTION: Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle . At high levels of branched-chain ketoacids, dephosphorylates and activates mitochondrial BCKDH complex, a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Tightly associates with the E2 component of BCKDH complex and dephosphorylates BCKDHA on Ser-337 . Regulates the reversible phosphorylation of ACLY in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. At fasting state, appears to dephosphorylate ACLY on Ser-455 and inactivate it. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively . Recognizes phosphosites having SxS or RxxS motifs and strictly depends on Mn(2+) ions for the phosphatase activity . Regulates Ca(2+)-induced opening of mitochondrial transition pore and apoptotic cell death . .

AccessionsV9GYI6
ENST00000510548.6
V9GYZ5
ENST00000608933.6 [Q8N3J5-1]
A0A0A0MQZ4
V9GY69
ENST00000514204.1
Q8N3J5
V9GYS8
ENST00000505022.1
ENST00000508256.5
ENST00000295908.11