Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| peripheral blood | 6 studies | 21% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 99% | 2035.40 | 357 / 359 | 100% | 46.06 | 286 / 286 |
| lung | 100% | 2737.66 | 577 / 578 | 99% | 30.96 | 1148 / 1155 |
| breast | 100% | 1907.50 | 458 / 459 | 98% | 24.86 | 1093 / 1118 |
| kidney | 100% | 5673.98 | 89 / 89 | 97% | 33.95 | 878 / 901 |
| thymus | 98% | 1084.59 | 640 / 653 | 95% | 44.01 | 575 / 605 |
| intestine | 93% | 1507.19 | 894 / 966 | 100% | 52.49 | 526 / 527 |
| skin | 99% | 1525.11 | 1799 / 1809 | 86% | 14.21 | 406 / 472 |
| esophagus | 85% | 1865.89 | 1234 / 1445 | 100% | 42.49 | 183 / 183 |
| uterus | 89% | 682.11 | 151 / 170 | 96% | 37.72 | 442 / 459 |
| bladder | 86% | 1433.86 | 18 / 21 | 98% | 36.12 | 496 / 504 |
| liver | 100% | 1758.56 | 226 / 226 | 81% | 13.47 | 327 / 406 |
| brain | 84% | 723.74 | 2210 / 2642 | 97% | 18.24 | 683 / 705 |
| adrenal gland | 95% | 1182.31 | 244 / 258 | 86% | 29.59 | 197 / 230 |
| pancreas | 78% | 524.69 | 255 / 328 | 99% | 37.07 | 177 / 178 |
| prostate | 89% | 854.69 | 218 / 245 | 85% | 10.62 | 426 / 502 |
| ovary | 26% | 159.33 | 47 / 180 | 94% | 21.64 | 404 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 47.30 | 29 / 29 |
| peripheral blood | 100% | 2840.85 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2578.04 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 32.23 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.47 | 1 / 1 |
| adipose | 100% | 2911.34 | 1201 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 89% | 1243.80 | 1189 / 1335 | 0% | 0 | 0 / 0 |
| heart | 77% | 791.79 | 660 / 861 | 0% | 0 | 0 / 0 |
| muscle | 14% | 98.30 | 114 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 13% | 1.22 | 10 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006139 | Biological process | nucleobase-containing compound metabolic process |
| GO_0042102 | Biological process | positive regulation of T cell proliferation |
| GO_0006204 | Biological process | IMP catabolic process |
| GO_0006157 | Biological process | deoxyadenosine catabolic process |
| GO_0000255 | Biological process | allantoin metabolic process |
| GO_0006149 | Biological process | deoxyinosine catabolic process |
| GO_0009165 | Biological process | nucleotide biosynthetic process |
| GO_0032743 | Biological process | positive regulation of interleukin-2 production |
| GO_0006166 | Biological process | purine ribonucleoside salvage |
| GO_0034418 | Biological process | urate biosynthetic process |
| GO_0046059 | Biological process | dAMP catabolic process |
| GO_0006955 | Biological process | immune response |
| GO_0006738 | Biological process | nicotinamide riboside catabolic process |
| GO_0043101 | Biological process | purine-containing compound salvage |
| GO_0006148 | Biological process | inosine catabolic process |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0046638 | Biological process | positive regulation of alpha-beta T cell differentiation |
| GO_0005576 | Cellular component | extracellular region |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0034774 | Cellular component | secretory granule lumen |
| GO_1904813 | Cellular component | ficolin-1-rich granule lumen |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0001882 | Molecular function | nucleoside binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0047975 | Molecular function | guanosine phosphorylase activity |
| GO_0004731 | Molecular function | purine-nucleoside phosphorylase activity |
| GO_0042301 | Molecular function | phosphate ion binding |
| GO_0002060 | Molecular function | purine nucleobase binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PNP |
| Protein name | Purine nucleoside phosphorylase (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) purine-nucleoside phosphorylase (EC 2.4.2.1) (Inosine-guanosine phosphorylase) Purine nucleoside phosphorylase Purine nucleoside phosphorylase (EC 2.4.2.1) (Inosine-guanosine phosphorylase) Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) |
| Synonyms | NP |
| Description | FUNCTION: Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate . Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine . . FUNCTION: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. . |
| Accessions | G3V2H3 ENST00000697614.1 ENST00000697613.1 ENST00000708857.1 G3V5M2 ENST00000553418.5 G3V393 ENST00000708853.1 P00491 ENST00000553591.2 ENST00000554065.1 ENST00000361505.10 A0A8V8TL37 |
