PIP4K2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000786Biological processpositive regulation of autophagosome assembly
GO_0061909Biological processautophagosome-lysosome fusion
GO_1902635Biological process1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0035855Biological processmegakaryocyte development
GO_0010506Biological processregulation of autophagy
GO_0090119Biological processvesicle-mediated cholesterol transport
GO_0005886Cellular componentplasma membrane
GO_0001750Cellular componentphotoreceptor outer segment
GO_0005764Cellular componentlysosome
GO_0005654Cellular componentnucleoplasm
GO_0001917Cellular componentphotoreceptor inner segment
GO_0005829Cellular componentcytosol
GO_0005776Cellular componentautophagosome
GO_0042803Molecular functionprotein homodimerization activity
GO_0016308Molecular function1-phosphatidylinositol-4-phosphate 5-kinase activity
GO_0016309Molecular function1-phosphatidylinositol-5-phosphate 4-kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePIP4K2A
Protein namePhosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PtdIns(5)P-4-kinase isoform 2-alpha)
Alternative protein PIP4K2A
SynonymsPI5P4KA
PIP5K2
PIP5K2A
DescriptionFUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) . Has both ATP- and GTP-dependent kinase activities . May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 . May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level . In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism . May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism . PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 . .

AccessionsENST00000604912.1
ENST00000545335.5 [P48426-2]
S4R320
ENST00000376573.9 [P48426-1]
L8EAD2
H7BXS3
P48426
ENST00000323883.11