PIK3C2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006897Biological processendocytosis
GO_0061024Biological processmembrane organization
GO_0014829Biological processvascular associated smooth muscle contraction
GO_0048015Biological processphosphatidylinositol-mediated signaling
GO_0090050Biological processpositive regulation of cell migration involved in sprouting angiogenesis
GO_0048008Biological processplatelet-derived growth factor receptor signaling pathway
GO_0036092Biological processphosphatidylinositol-3-phosphate biosynthetic process
GO_0048268Biological processclathrin coat assembly
GO_0008286Biological processinsulin receptor signaling pathway
GO_0006887Biological processexocytosis
GO_0010508Biological processpositive regulation of autophagy
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0016477Biological processcell migration
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0005886Cellular componentplasma membrane
GO_0005942Cellular componentphosphatidylinositol 3-kinase complex
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005802Cellular componenttrans-Golgi network
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0031982Cellular componentvesicle
GO_0046934Molecular function1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO_0035091Molecular functionphosphatidylinositol binding
GO_0005524Molecular functionATP binding
GO_0016303Molecular function1-phosphatidylinositol-3-kinase activity
GO_0030276Molecular functionclathrin binding
GO_0035005Molecular function1-phosphatidylinositol-4-phosphate 3-kinase activity

IV. Literature review

[source]
Gene namePIK3C2A
Protein namePhosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha)
Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms
DescriptionFUNCTION: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components . .

AccessionsE9PPP3
ENST00000532035.1
ENST00000533645.1
L7RRS0
O00443
ENST00000691414.1 [O00443-1]
A0A0C4DGF9
ENST00000265970.11 [O00443-1]