PFDN4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	13 studies	26% ± 10%	Explore
fibroblast	11 studies	31% ± 10%	Explore
smooth muscle cell	11 studies	22% ± 4%	Explore
connective tissue cell	10 studies	27% ± 6%	Explore
regulatory T cell	9 studies	21% ± 4%	Explore
CD4-positive, alpha-beta T cell	8 studies	20% ± 6%	Explore
natural killer cell	8 studies	22% ± 6%	Explore
pericyte	8 studies	24% ± 7%	Explore
B cell	7 studies	23% ± 6%	Explore
myofibroblast cell	7 studies	23% ± 6%	Explore
epithelial cell	7 studies	40% ± 20%	Explore
basal cell	7 studies	26% ± 12%	Explore
endothelial cell of lymphatic vessel	7 studies	25% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	20% ± 2%	Explore
conventional dendritic cell	6 studies	28% ± 11%	Explore
neuron	6 studies	42% ± 21%	Explore
capillary endothelial cell	5 studies	18% ± 2%	Explore
macrophage	5 studies	25% ± 6%	Explore
CD8-positive, alpha-beta T cell	5 studies	21% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	17% ± 2%	Explore
classical monocyte	4 studies	25% ± 5%	Explore
progenitor cell	4 studies	22% ± 7%	Explore
T cell	4 studies	22% ± 8%	Explore
ciliated cell	4 studies	35% ± 10%	Explore
glutamatergic neuron	4 studies	32% ± 12%	Explore
plasmacytoid dendritic cell	4 studies	23% ± 5%	Explore
hematopoietic precursor cell	3 studies	32% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	20% ± 4%	Explore
exhausted T cell	3 studies	26% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	21% ± 5%	Explore
non-classical monocyte	3 studies	29% ± 5%	Explore
monocyte	3 studies	16% ± 0%	Explore
endothelial cell of artery	3 studies	20% ± 4%	Explore
mesothelial cell	3 studies	33% ± 19%	Explore
neural crest cell	3 studies	32% ± 9%	Explore
memory B cell	3 studies	16% ± 1%	Explore
retinal ganglion cell	3 studies	57% ± 23%	Explore
erythroblast	3 studies	35% ± 19%	Explore
pro-B cell	3 studies	22% ± 2%	Explore
amacrine cell	3 studies	32% ± 11%	Explore
abnormal cell	3 studies	22% ± 4%	Explore
endothelial cell of vascular tree	3 studies	18% ± 2%	Explore
GABAergic neuron	3 studies	26% ± 6%	Explore
hematopoietic stem cell	3 studies	19% ± 2%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	37% ± 22%	Explore
enteroendocrine cell	3 studies	28% ± 14%	Explore
mononuclear phagocyte	3 studies	23% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	22% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	22% ± 6%	Explore
lung	6 studies	25% ± 8%	Explore
intestine	5 studies	22% ± 10%	Explore
brain	5 studies	22% ± 6%	Explore
kidney	3 studies	20% ± 4%	Explore
eye	3 studies	24% ± 7%	Explore
thymus	3 studies	29% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	689.99	1445 / 1445	100%	36.72	183 / 183
ovary	100%	773.37	180 / 180	100%	51.25	430 / 430
uterus	100%	830.18	170 / 170	100%	49.73	459 / 459
brain	100%	1008.74	2638 / 2642	100%	33.27	705 / 705
breast	100%	774.79	459 / 459	99%	40.60	1112 / 1118
stomach	100%	507.04	359 / 359	99%	48.36	284 / 286
thymus	100%	492.00	650 / 653	100%	26.63	603 / 605
bladder	100%	806.57	21 / 21	99%	50.69	500 / 504
kidney	100%	597.78	89 / 89	99%	25.96	892 / 901
prostate	100%	632.14	244 / 245	99%	27.53	498 / 502
lung	99%	488.89	571 / 578	100%	42.53	1155 / 1155
adrenal gland	100%	652.30	258 / 258	99%	35.72	227 / 230
intestine	100%	735.49	966 / 966	97%	48.17	513 / 527
pancreas	96%	351.93	316 / 328	99%	34.07	177 / 178
liver	96%	268.35	218 / 226	96%	21.26	391 / 406
skin	92%	690.94	1662 / 1809	95%	37.05	450 / 472
adipose	100%	745.50	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	43.51	29 / 29
spleen	100%	546.72	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	36.66	45 / 45
ureter	0%	0	0 / 0	100%	26.70	1 / 1
blood vessel	100%	849.79	1332 / 1335	0%	0	0 / 0
muscle	100%	629.17	800 / 803	0%	0	0 / 0
heart	99%	575.52	850 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	93%	20.91	74 / 80
peripheral blood	22%	335.43	204 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006457	Biological process	protein folding
GO_0061077	Biological process	chaperone-mediated protein folding
GO_1905907	Biological process	negative regulation of amyloid fibril formation
GO_0005829	Cellular component	cytosol
GO_0016272	Cellular component	prefoldin complex
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0051082	Molecular function	unfolded protein binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0001540	Molecular function	amyloid-beta binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PFDN4
Protein name	Prefoldin subunit 4 Prefoldin subunit 4 (Protein C-1) Alternative protein PFDN4
Synonyms	PFD4
Description	FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. . FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. .
Accessions	ENST00000371419.7 L8EC97 ENST00000441080.2 Q9NQP4 E9PQY2

PFDN4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review