PERP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
epithelial cell	23 studies	63% ± 24%	Explore
basal cell	22 studies	77% ± 20%	Explore
ciliated cell	17 studies	71% ± 18%	Explore
fibroblast	13 studies	24% ± 8%	Explore
secretory cell	11 studies	68% ± 20%	Explore
endothelial cell of lymphatic vessel	9 studies	29% ± 12%	Explore
pericyte	8 studies	43% ± 10%	Explore
type I pneumocyte	8 studies	49% ± 11%	Explore
endothelial cell	8 studies	30% ± 12%	Explore
smooth muscle cell	7 studies	24% ± 9%	Explore
type II pneumocyte	7 studies	25% ± 9%	Explore
club cell	7 studies	75% ± 12%	Explore
ionocyte	7 studies	65% ± 23%	Explore
respiratory goblet cell	7 studies	75% ± 16%	Explore
goblet cell	7 studies	33% ± 17%	Explore
brush cell	7 studies	52% ± 27%	Explore
enterocyte	6 studies	35% ± 9%	Explore
abnormal cell	6 studies	38% ± 21%	Explore
intestinal crypt stem cell	5 studies	31% ± 11%	Explore
progenitor cell	5 studies	44% ± 14%	Explore
keratinocyte	5 studies	84% ± 21%	Explore
deuterosomal cell	4 studies	59% ± 10%	Explore
duct epithelial cell	4 studies	86% ± 2%	Explore
squamous epithelial cell	4 studies	68% ± 11%	Explore
pancreatic A cell	4 studies	55% ± 13%	Explore
type B pancreatic cell	4 studies	74% ± 14%	Explore
transit amplifying cell	4 studies	39% ± 22%	Explore
kidney loop of Henle epithelial cell	4 studies	36% ± 15%	Explore
mucus secreting cell	4 studies	50% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	77% ± 9%	Explore
luminal cell of prostate epithelium	4 studies	49% ± 22%	Explore
endothelial cell of vascular tree	4 studies	29% ± 13%	Explore
hillock cell	3 studies	72% ± 26%	Explore
pancreatic D cell	3 studies	65% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	33% ± 15%	Explore
enteroendocrine cell	3 studies	34% ± 2%	Explore
renal alpha-intercalated cell	3 studies	31% ± 6%	Explore
extravillous trophoblast	3 studies	90% ± 1%	Explore
placental villous trophoblast	3 studies	95% ± 2%	Explore
mucosal invariant T cell	3 studies	20% ± 5%	Explore
serous secreting cell	3 studies	50% ± 17%	Explore
acinar cell	3 studies	40% ± 26%	Explore
CD4-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
vein endothelial cell	3 studies	21% ± 2%	Explore
pancreatic ductal cell	3 studies	84% ± 5%	Explore
T cell	3 studies	23% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	62% ± 27%	Explore
hepatocyte	3 studies	37% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	9 studies	41% ± 24%	Explore
intestine	5 studies	21% ± 8%	Explore
pancreas	4 studies	60% ± 16%	Explore
esophagus	4 studies	57% ± 22%	Explore
prostate	4 studies	55% ± 23%	Explore
breast	4 studies	36% ± 12%	Explore
skin	4 studies	43% ± 20%	Explore
placenta	3 studies	63% ± 28%	Explore
eye	3 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	58%	56666.50	845 / 1445	96%	976.59	176 / 183
prostate	38%	5554.55	92 / 245	94%	164.31	473 / 502
breast	36%	5730.98	167 / 459	89%	235.14	997 / 1118
bladder	29%	5587.90	6 / 21	96%	549.34	484 / 504
intestine	11%	1483.76	108 / 966	95%	372.74	503 / 527
skin	74%	155880.34	1336 / 1809	30%	72.76	143 / 472
ureter	0%	0	0 / 0	100%	162.33	1 / 1
tonsil	0%	0	0 / 0	98%	1220.03	44 / 45
lung	2%	209.57	9 / 578	94%	617.09	1081 / 1155
pancreas	1%	161.12	3 / 328	93%	313.83	165 / 178
stomach	4%	511.86	13 / 359	89%	277.33	255 / 286
uterus	2%	1546.48	4 / 170	85%	886.39	390 / 459
thymus	0%	0	0 / 653	81%	193.71	493 / 605
ovary	0%	0	0 / 180	79%	132.98	338 / 430
liver	9%	1196.45	21 / 226	60%	97.02	242 / 406
kidney	2%	282.02	2 / 89	53%	86.99	482 / 901
adrenal gland	0%	65.14	1 / 258	29%	36.43	66 / 230
adipose	7%	1148.55	80 / 1204	0%	0	0 / 0
heart	5%	641.91	43 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	4%	3.44	3 / 80
blood vessel	0%	146.73	4 / 1335	0%	0	0 / 0
brain	0%	0	0 / 2642	0%	0.29	2 / 705
muscle	0%	53.78	2 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0

III. Associated gene sets

GO_0001894	Biological process	tissue homeostasis
GO_0070234	Biological process	positive regulation of T cell apoptotic process
GO_0034113	Biological process	heterotypic cell-cell adhesion
GO_0072332	Biological process	intrinsic apoptotic signaling pathway by p53 class mediator
GO_0098609	Biological process	cell-cell adhesion
GO_0002934	Biological process	desmosome organization
GO_0007219	Biological process	Notch signaling pathway
GO_0060603	Biological process	mammary gland duct morphogenesis
GO_0097186	Biological process	amelogenesis
GO_0045862	Biological process	positive regulation of proteolysis
GO_0097202	Biological process	activation of cysteine-type endopeptidase activity
GO_0090023	Biological process	positive regulation of neutrophil chemotaxis
GO_0005911	Cellular component	cell-cell junction
GO_0030057	Cellular component	desmosome
GO_0005794	Cellular component	Golgi apparatus
GO_0005886	Cellular component	plasma membrane
GO_0005739	Cellular component	mitochondrion
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PERP
Protein name	p53 apoptosis effector related to PMP-22 (Keratinocyte-associated protein 1) (KCP-1) (P53-induced protein PIGPC1) (Transmembrane protein THW)
Synonyms	KCP1 THW PIGPC1 KRTCAP1
Description	FUNCTION: Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. .; FUNCTION: Plays a role as an effector in the TP53-dependent apoptotic pathway. .
Accessions	Q96FX8 ENST00000421351.4

PERP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review